“…33 and 41) and accelerates the progression of atherosclerosis (10). Hcy increases blood-brain barrier permeability (12,17) and is a risk factor for neurodegenerative disease (25,34,35), especially Alzheimer disease (AD) (6,19,31). Even mildly elevated Hcy (Ͼ14 mol/l) creates a twofold increase in risk of AD with a significant correlation between blood Hcy concentration and cognitive impairment (8,31).…”