Serum hsa_circ_0079480 is a novel prognostic marker for acute myeloid leukemia

Guo, Liang; Kou, Ru; Song, Yanping; Li, Guang; Jia, Xueyou; Li, Zhenzhen; Zhang, Yunjie

doi:10.1002/jcla.24337

Cited by 9 publications

(2 citation statements)

References 26 publications

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“…Recently, a number of circRNAs have been found to be aberrantly expressed in leukemia. A growing body of evidence points the use of circRNAs as effective biomarkers for the diagnosis and prognosis of leukemia due to their unique properties ( Guo et al, 2022 ; Tayel et al, 2022 ; Zhou et al, 2022a ). For example, the upregulation of circ_0009910 predicted poor diagnosis and prognosis in AML patients.…”

Section: Survey Methodologymentioning

confidence: 99%

CircRNA: a rising star in leukemia

Li,

Ren,

Wang

et al. 2023

PeerJ

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Non-coding RNA are a class of RNA that lack the potential to encode proteins. CircRNAs, generated by a post-splicing mechanism, are a newly discovered type of non-coding RNA with multi-functional covalent loop structures. CircRNAs may play an important role in the occurrence and progression of tumors. Research has shown that circRNAs are aberrantly expressed in various types of human cancers, including leukemia. In this review, we summarize the expression and function of circRNAs and their impact on different types of leukemia. We also illustrate the function of circRNAs on immune modulation and chemoresistance in leukemia and their impact on its diagnosis and prognosis. Herein, we provide an understanding of recent advances in research that highlight the importance of circRNAs in proliferation, apoptosis, migration, and autophagy in different types of leukemia. Furthermore, circRNAs make an indispensable difference in the modulation of the immunity and chemoresistance of leukemia. Increasing evidence suggests that circRNAs may play a vital role in the diagnostic and prognostic markers of leukemia because of their prominent properties. More detailed preclinical studies on circRNAs are needed to explore effective ways in which they can serve as biomarkers for the diagnosis and prognosis of leukemia in vivo.

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Section: Survey Methodologymentioning

confidence: 99%

CircRNA: a rising star in leukemia

Li,

Ren,

Wang

et al. 2023

PeerJ

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“…Furthermore, has_circ_0079480 expression levels were decreased after treatment and in patients that achieved complete remission. Based on these results, has_circ_0079480 may have a prognostic utility in AML [ 66 ].…”

Section: Circrnasmentioning

confidence: 99%

Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia

Yeh

Cheong

Tay

2023

IJMS

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Before the advent of next-generation sequencing, research on acute myeloid leukemia (AML) mostly centered on protein-coding genes. In recent years, breakthroughs in RNA sequencing technologies and whole transcriptome analysis have led to the discovery that approximately 97.5% of the human genome is transcribed into non-coding RNAs (ncRNAs). This paradigm shift has led to an explosion of research interest in different classes of non-coding RNAs, such as circular RNAs (circRNAs) as well as non-coding untranslated regions (UTRs) of protein-coding messenger RNAs. The critical roles of circRNAs and UTRs in AML pathogenesis have become increasingly apparent. In this review, we discuss the cellular mechanisms of circRNAs and summarize recent studies that reveal their biological roles in AML. Furthermore, we also review the contribution of 3′UTRs to disease progression. Finally, we discuss the potential of circRNAs and 3′UTRs as new biomarkers for disease stratification and/or the prediction of treatment response and targets for the development of RNA-directed therapeutic applications.

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Serum hsa_circ_0079480 is a novel prognostic marker for acute myeloid leukemia

Guo

Kou

Song

et al. 2022

Clinical Laboratory Analysis

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Background The dysregulated expression of serum circular RNAs (circRNAs) has previously been linked to the prognosis of acute myeloid leukemia (AML) patients, but the clinical and prognostic relevance of serum hsa_circ_0079480 levels in this oncogenic setting have yet to be established. Herein, we assessed the putative prognostic relevance of circulating hsa_circ_0079480 levels in AML patient serum. Methods Serum was prepared from blood samples collected from 236 AML patients and 160 healthy controls, with hsa_circ_0079480 levels therein being quantified by quantitative real‐time reverse transcription‐polymerase chain reaction (qRT‐PCR) after which the clinical value of these levels was assessed. Results Acute myeloid leukemia patients were found to exhibit significant hsa_circ_0079480 upregulation in their serum as compared to serum from healthy controls, with such upregulation being most profound in individuals with M4/M5 type disease and to be more common in patients with poor cytogenic risk or high white blood cell counts. Receiver operating characteristic (ROC) curves demonstrated that serum hsa_circ_0079480 levels were able to effectively differentiate between patients with AML and healthy controls. Moreover, the upregulation of serum hsa_circ_0079480 was found to be closely related to clinicopathological findings and to be an independent predictor of reduced overall and relapse‐free survival among individuals diagnosed with AML. Furthermore, serum hsa_circ_0079480 levels were markedly decreased after treatment in this patient population, with these levels being lower in patients that achieved complete remission as compared to those patients that did not. Conclusion Levels of hsa_circ_0079480 in patient serum may offer value as a prognostic biomarker in AML.

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Serum hsa_circ_0079480 is a novel prognostic marker for acute myeloid leukemia

Cited by 9 publications

References 26 publications

CircRNA: a rising star in leukemia

CircRNA: a rising star in leukemia

Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia

Serum hsa_circ_0079480 is a novel prognostic marker for acute myeloid leukemia

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