Serum hyaluronan as a marker of liver fibrosis in chronic viral hepatitis C: effect of α-interferon therapy

Guéchot, Jérôme; Loria, Alain; Serfaty, Lawrence; Giral, Philippe; Giboudeau, J; Poupon, Raoul

doi:10.1016/0168-8278(95)80255-x

Cited by 113 publications

(47 citation statements)

References 18 publications

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“…Other studies of hepatitis in patients with and without active cirrhosis of autoimmune and viral aetiology showed that serum hyaluronan determinations could differentiate between chronic active hepatitis and active cirrhosis [15,29]. Guéchot J et al [30,31] found that serum hyaluronan levels correlated with severity of liver fibrosis and could be used as a non-invasive index of liver fibrosis in chronic viral hepatitis.…”

Section: Other Conditionsmentioning

confidence: 99%

Is serum hyaluronan a helpful tool in the management of patients with liver diseases?

Lindqvist

1997

Journal of Internal Medicine

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Lindqvist U (University Hospital, Uppsala, Sweden). Is serum hyaluronan a helpful tool in the management of patients with liver diseases? (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 67–71. The results of serial determinations of serum hyaluronan indicate a prognostic value in progressive liver damage. In primary biliary cirrhosis and in cirrhotic alcoholic liver diseases serum hyaluronan level discriminates between early and advanced disease. In alcoholic liver disease serum hyaluronan can be applied as assessment of haemodynamic changes. Serum hyaluronan is of use as a non‐invasive index of liver fibrosis in chronic viral hepatitis. A reversible defect in the hyaluronan receptor of the hepatic endothelial cells was suggested following studies on paracetamol‐induced acute liver damage. In liver transplantation, graft function can be predicted by determination of the venous effluent of hyaluronan.

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Section: Other Conditionsmentioning

confidence: 99%

Is serum hyaluronan a helpful tool in the management of patients with liver diseases?

Lindqvist

1997

Journal of Internal Medicine

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“…Such studies also report that HA is not correlated to histopathological indexes of hepatic inflammation or necrosis (5,12,23) . Thus, HA may be very useful for monitoring anti-fibrosis therapeutics in patients with chronic hepatitis being treated with interferon (6,8,14) .…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors

Camacho

Silveira

Oliveira

et al. 2007

Arq. Gastroenterol.

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-Background -Serologic markers have been proposed for monitoring hepatic fibrosis in chronic liver disease. Among fibrosis markers, type III procollagen (PIIIP) and hyaluronic acid have been studied in these patients. Aim -To evaluate the association between these serum markers with histological findings. Methods -A prospective cross-sectional study was carried out with HCV-positive blood donors. The studied population included men and women whose age ranged from 18 to 60 years, with elevated liver function tests [ALT levels ≥ 1.5 times the normal value and alterations of two or more of the following: any changes in the levels of ALT, aspartate aminotransferase, conjugated bilirrubin, gammaglobulin, gammaglutamyltranspeptidase, albumin, platelet count; alkaline phosphatase levels ≥1.5 times the normal value, or prothrombin time below 70% and above 60%]. Fourty-nine patients were submitted to liver biopsy, blood analysis of PIIIP, hyaluronic acid, besides liver function tests.

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“…The determination of serum HA levels is useful for assessing the degree of liver fibrosis and for monitoring liver function [13][14][15][16] and thus is a topic of high interest for the treatment of patients in our departmental hepatology outpatient clinic. Monitoring serum HA is also used in other areas, such as in septic conditions, tumor growth (such as Wilm's tumor and malignant mesothelioma), and for the diagnosis of rare hereditary diseases (such as Werner's syndrome and cutaneous hyaluronanosis) [4].…”

Section: Introductionmentioning

confidence: 99%

“…Increased production of HA in the connective tissue surrounding the joints is stimulated by various inflammatory conditions and thus can be used to monitor joint condition [10,11]. Increased serum HA levels may also arise from various liver diseases characterized by liver fibrosis and cirrhosis, due to decreased hepatic removal and/or increased hepatic production of HA during liver inflammation [12,13].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the disaccharides derived from hyaluronic acid and chondroitin sulfate by capillary electrophoresis with sample stacking

Yang

Breadmore

Thormann³

2005

J of Separation Science

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Analysis of the disaccharides derived from hyaluronic acid and chondroitin sulfate by capillary electrophoresis with sample stacking CE conditions for monitoring the unsaturated disaccharides of hyaluronic acid (di-HA) and chondroitin sulfate (di-CS) using an alkaline tetraborate buffer, electrokinetic sample injection, and UV absorption detection at 232 nm are reported. Separations were performed in an uncoated fused-silica capillary having reversed polarity and reversed electroosmosis generated with the addition of CTAB to the buffer. The influence of various separation parameters, including the concentration of CTAB, buffer pH, concentration of tetraborate, and applied voltage, on the resolution of the two disaccharides was investigated. Baseline separation was obtained with 25 mM tetraborate at pH 10.0 and having 0.05 mM CTAB. Chloride and phosphate in the sample are beneficial for the stacking of the disaccharides, with di-HA forming a much sharper peak than di-CS. Using samples prepared in 25 mM Tris-HCl (pH 7.5) and electrokinetic injection at the cathode at -10 kV for 40 s, linear relationships between the corrected peak area and the concentration of the disaccharides have been found in the ranges of 1.0-400.0 and 0.1-1.0 lg/mL (0.2-1.0 lg/mL for di-CS), with correlation coefficients being A0.9933 in all cases. The RSDs of detection times and corrected peak areas were between 1.13-1.24 and 1.57-2.13%, respectively. Applied to human serum samples that were prepared by ethanol precipitation and depolymerization of the two polysaccharides with chondroitinase ABC reveals comigration of endogenous compounds with di-HA and a sample-dependent detection time. The di-HA content in the serum sample can be estimated via subtraction of the blank peak that is obtained without enzymatic hydrolysis.

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Serum hyaluronan as a marker of liver fibrosis in chronic viral hepatitis C: effect of α-interferon therapy

Cited by 113 publications

References 18 publications

Is serum hyaluronan a helpful tool in the management of patients with liver diseases?

Is serum hyaluronan a helpful tool in the management of patients with liver diseases?

Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors

Analysis of the disaccharides derived from hyaluronic acid and chondroitin sulfate by capillary electrophoresis with sample stacking

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