Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis – a five-year prospective cohort study

Sasaki, Eiji; Tsuda, Eiichi; Yamamoto, Yuji; Maeda, Shugo; Inoüe, Ryo; Chiba, Daisuke; Fujita, Hiroshi; Takahashi, Ippei; Umeda, Takashi; Nakaji, Shigeyuki; Ishibashi, Yasuyuki

doi:10.1186/s13075-015-0793-0

Cited by 48 publications

(50 citation statements)

References 47 publications

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“…These results add to the growing evidence that the clinical course of OA may be associated with systemic inflammation (2,5,10). Several serum biomarkers are known to be correlated with OA incidence and progression and have thus been proposed as diagnostic and prognostic markers for knee OA (28)(29)(30)(31). Serum hyaluronic acid concentration was found to be positively associated with progression of Kellgren/Lawrence grade in knees with and without OA (31).…”

Section: Discussionsupporting

confidence: 56%

“…Several serum biomarkers are known to be correlated with OA incidence and progression and have thus been proposed as diagnostic and prognostic markers for knee OA (28)(29)(30)(31). Serum hyaluronic acid concentration was found to be positively associated with progression of Kellgren/Lawrence grade in knees with and without OA (31). Serum concentration of keratan sulfate was suggested to be a potential marker of cartilage destruction (32).…”

Section: Discussionmentioning

confidence: 99%

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Cross‐Sectional and Longitudinal Associations Between Serum Levels of High‐Sensitivity C‐Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis

Zhu

Jin

Wang

et al. 2016

Arthritis Care & Research

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Objective. To describe associations between serum high-sensitivity C-reactive protein (hsCRP), knee bone marrow lesions (BMLs), and knee pain, cross-sectionally and longitudinally, in patients with knee osteoarthritis (OA). Methods. Patients (n 5 192) with symptomatic knee OA (mean age 63 years, range 50-79, women 53%) were assessed at baseline and after 24 months. Serum hsCRP was measured using enzyme-linked immunosorbent assay. Knee BMLs were scored using the modified Whole-Organ Magnetic Resonance Imaging (MRI) Score from T2-weighted fat-supressed fast spin-echo MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index. Results. Quartiles of baseline serum hsCRP were associated with the presence of knee BMLs (prevalence ratio 1.07 per quartile [95% confidence interval (95% CI) 1.00, 1.15]) and total knee pain scores (b 13.66 per quartile [95% CI 2.26, 25.07]) in multivariable analyses. Longitudinally, higher baseline hsCRP was associated with an increase in BML score (risk ratio 1.37 per quartile [95% CI 1.10, 1.70]), and change in hsCRP was positively associated with change in BML score (b 0.19 [95% CI 0.05, 0.34]) in adjusted analyses. Baseline hsCRP was not associated with change in total knee pain, but change in hsCRP was positively and significantly associated with change in total knee pain (b 4.71 [95% CI 0.48, 8.94]). This became nonsignificant after adjustment for changes in BML score. Conclusion. In patients with knee OA, serum hsCRP is associated with knee BML scores and, to a lesser extent, pain both cross-sectionally and longitudinally, suggesting that inflammation is linked with BMLs and their associated pain.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Cross‐Sectional and Longitudinal Associations Between Serum Levels of High‐Sensitivity C‐Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis

Zhu

Jin

Wang

et al. 2016

Arthritis Care & Research

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“…Several cross-sectional studies have reported that measuring sHA level may be useful for not only diagnosing knee OA but also identifying disease duration, severity, and the extent of OA-related knee pain. Therefore, sHA may have potential as a prognostic indicator of progressive knee OA, but the relationship between sHA and knee OA has only been examined in a few longitudinal studies [4,6,7] . Hyaluronan, also known as Hyaluronic acid (HA) or hyaluronate is a large linear non-sulfated glycosaminoglycan (GAG) with a molecular weight between10/6 and 10/7 Da.…”

Section: Introductionmentioning

confidence: 99%

“…OA should be diagnosed as soon as possible to begin treatment but the current diagnostic tools are inadequate to pick up preclinical changes. The gold standard method of diagnosis has long been plain radiography, but the sensitivity and specificity of that technique have been questioned [4] . However, when radiological diagnosis is established, significant joint damage has often already occurred.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of serum hyaluronic acid with clinical and radiological severity in primary knee osteoarthritis

Mittal¹,

Chhabra²,

Kumar³

et al. 2018

Int. J. Orthop. Sci.

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Objective: To investigate relationship between serum hyaluronic acid (sHA) level and the presence and severity of radiographic knee osteoarthritis (OA) as well as degree of knee pain. Design: A total of 150 subjects (75 controls and 75 cases) were enrolled in this study. Based on the Kellgrene Lawrence (K-L) grade, participants were radiographically classified into three groups: mild (K-L grade1 & 2), moderate (K-L grade 3) and severe (K-L grade 4). The degree of knee pain was quantified by WOMAC knee pain score. sHA levels were compared among the controls & cases and with radiological grading. In addition, the correlation between sHA level and the degree of knee pain was analyzed in each group. Results: In relationship between sHA level and the severity of radiographic knee OA, sHA level of the case group was significantly higher than in the normal group (P< 0.001). Furthermore, sHA level correlated with the severity of radiographic knee OA (r = 0.880). sHA level had positive correlation and significant association with WOMAC knee pain in study groups. (r = 0.750, P<0.001) Conclusion: sHA level has the potential to be useful for the diagnosis and prognosis of the severity of primary knee OA.

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Joint line convergence angle is the most associated alignment factor with the severity of medial knee osteoarthritis

Tsushima,

Sasaki,

Sakamoto

et al. 2024

J. exp. orthop.

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PurposeThe purpose of this study was to evaluate the relationship between the joint line convergence angle (JLCA) and the severity of medial knee osteoarthritis (OA). We hypothesise that JLCA is the most associated factor with the severity of medial knee OA.MethodsThis retrospective study included a total of 202 knees that underwent either high tibial osteotomy or medial meniscus repair/partial resection. Kellgren–Lawrence grade and hip–knee–ankle angle (HKAA), mechanical lateral distal femoral angle (mLDFA), medial proximal tibial angle (MPTA) and JLCA were assessed from preoperative radiographs. Medial meniscus extrusion (MME) was measured using preoperative magnetic resonance imaging. The International Cartilage Research Society (ICRS) grade on the medial femoral condyle and medial tibial plateau were also assessed. The relationships between JLCA and Kellgren–Lawrence grades and MME and ICRS grades were analysed using Spearman's correlation test and regression analysis.ResultsThe JLCA was correlated with the Kellgren–Lawrence grade (R = 0.765, p < 0.001), MME (R = 0.638, p < 0.001), ICRS grade on the MFC (R = 0.586, p < 0.001) and the MTP (R = 0.586, p < 0.001). Regression analysis showed that age (p = 0.002) and JLCA (p < 0.001) were associated with Kellgren–Lawrence grade. Furthermore, JLCA was related to ICRS grade on the MFC (p < 0.001) and MTP (p < 0.001).ConclusionThe JLCA, reflecting radiological severity, meniscus status, and cartilage lesion, was the most associated alignment parameter in the severity of medial knee OA. The JLCA may be beneficial for quantitative assessment of medial knee OA.Level of EvidenceLevel III, retrospective cohort study.

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Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis – a five-year prospective cohort study

Cited by 48 publications

References 47 publications

Cross‐Sectional and Longitudinal Associations Between Serum Levels of High‐Sensitivity C‐Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis

Cross‐Sectional and Longitudinal Associations Between Serum Levels of High‐Sensitivity C‐Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis

Correlation of serum hyaluronic acid with clinical and radiological severity in primary knee osteoarthritis

Joint line convergence angle is the most associated alignment factor with the severity of medial knee osteoarthritis

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