Serum IgE levels in parents and children

Gerrard, J. W.; Horne, Sebastian; Vickers, Peter S.; MacKenzie, Janine; Goluboff, Nathan; Garson, John Z.; Maningas, C. S.

doi:10.1016/s0022-3476(74)80510-x

Cited by 51 publications

(5 citation statements)

References 10 publications

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“…We hypothesize that sex hormone may affect the level of serum IgE. In terms of age, the concentration of tIgE is observed to increase from birth to adolescence and then decrease during adulthood, which has been validated in a previous study [ 40 , 41 ]. It has been suggested that the level of tIgE in Th2-driven respiratory inflammatory diseases is significantly higher than that in inflammatory skin diseases.…”

Section: Discussionsupporting

confidence: 72%

Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China

Zhang

Guo

Wang

et al. 2021

Mediators of Inflammation

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Background. Immunoglobulin E (IgE) is the most important promoter of allergic inflammation. However, there are few systematic studies on IgE in age range, genders, disease spectrum, and time regularity. Aim. To screen the common allergens, allergen spectrum, and IgE difference between type 2 inflammatory allergic diseases and other allergic diseases in Weifang, China. Methods. A retrospective study was performed by estimating patients’ clinical data suffering from allergic diseases (urticaria, pollinosis, allergic rhinitis, atopic dermatitis, and bronchial asthma) between May 2019 and April 2020 using an allergen detection kit of Macro-Union Pharmaceutical. Results. 732 of the 1367 patients showed different antigen positive, and the positive rate was 53.5%. The most common allergens were dust mites, mixed fungi, Artemisia pollen, cat/dog dander, and cockroaches. There were 27.0% (369/1367) of the patients with single positive allergen-specific IgE (sIgE), 26.5% (363/1367) with multiple-positive IgE. The total immunoglobulin E (tIgE) levels varied with gender, age, and type of disease. There was a difference in the distribution of allergens between children and adults. A positive correlation between the serum-specific IgE and the corresponding local inhaled allergen density was observed. Conclusions. In this study, we found that type 2 inflammatory allergic diseases have higher serum IgE and a higher probability of inhaled sIgE positive. According to age, gender, and condition, serological IgE detection of allergens provides new insight into the early diagnosis and prevention of allergic diseases.

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Section: Discussionsupporting

confidence: 72%

Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China

Zhang

Guo

Wang

et al. 2021

Mediators of Inflammation

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“…It has been shown that it is higher in atop ic individuals than in normal subjects [4][5][6]. The genetic influ ence on serum IgE levels was further confirmed by studies of nuclear families and monozygous twins [7][8][9][10]. The genetic control of IgE production has also been observed in experi mental animals of both rats and mice [11][12][13][14].…”

mentioning

confidence: 99%

Influence of Genetic and Environmental Factors on Surface Expression and Occupancy of IgE Receptors and on Histamine Releasability of Mast Cells

Chen

Enerbäck²

1995

Int Arch Allergy Immunol

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The relationship between the IgE load on mast cells and their secretory capacity when challenged with anti-IgE was studied in peritoneal cells obtained from rats of three different strains, Hooded Lister (HL), Wistar Kyoto (WKY) and Sprague-Dawley (SD). IgE was determined cytofluorometrically after labelling with FITC-conjugated anti-IgE before and after the saturation of the IgE receptors to provide a measure of the surface expression of IgE receptors (number of receptors available for bindings) as well as the IgE occupancy of the receptors (native IgE content). The secretory capacity of the mast cells was examined in vitro in terms of histamine release as a function of anti-IgE concentration. Mast cells obtained from HL and WKY rats were found to carry significantly higher levels of IgE receptors and IgE than the mast cells of SD rats bred and raised under the same conventional laboratory conditions. The mast cells of SD rats kept under barrier-maintained conditions carried significantly less IgE than the mast cells obtained from SD rats kept under conventional conditions, but their IgE receptor levels were similar. The IgE-mediated histamine-releasing capacity of the mast cells, evaluated in terms of maximum release or of the slopes of regression lines (histamine release versus anti-IgE concentration), was positively correlated to the levels of native IgE and IgE receptors in the three strains of rat combined. The mast cells obtained from WKY rats showed the highest secretory capacity in the three strains of rat examined, significantly higher than the mast cells of HL rats, even though the latter displayed similar levels of IgE and IgE receptors. These findings indicate that under basal conditions in these strains of rat the number of IgE receptors available for binding as well as the IgE occupancy is determined by both the genetic background and the environment. The IgE-mediated histamine release appeared to be largely, but not exclusively a function of the number of IgE-receptor complexes on the mast-cell surface. The difference in histamine-releasing capacity between WKY and HL rats suggests that genetic factors may control the secretory capacity of the mast cells also through mechanisms other than those involving the expression of IgE receptors and the binding of IgE by the mast cells.

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“…A significant body of research exists to suggest that such measures may be beneficial. Several reports in humans involving the study of mothers and their normal offspring (3), twins (2), and families (28) suggest the heritability of serum IgE levels. Thus, allergic parents, who are in tum more likely to have allergic offspring, can be identified by the use of medical history, physical examina tion, determination of the serum IgE level, and, in certain cases, the use of selected skin tests.…”

Section: Preventionmentioning

confidence: 99%