This paper discusses the particular ethical issues that are present when attempting to undertake research involving patients accessing palliative care for cancer. It focuses on the use of Hammick's research ethics wheel (REW) in relation to a research study undertaken by the authors. Applying the REW enabled the authors to identify and incorporate the ethical issues and dilemmas inherent within such a study at a practical level. Ethical reasons for undertaking research with such vulnerable participants are explained and justified with reference to the REW. Ethical considerations are crucial to any research study involving human participants, but particularly so when dealing with participants who are as vulnerable as those in a palliative care setting. The use of the REW enabled the authors to feel confident that all such concerns had been identified before data collection began.

The rapid manual ParaSight-F test for Plasmodium falciparum is an antigen capture test detecting trophozoite-derived histidine rich protein II, is simple and provides a definitive diagnosis within 10 min. Compared with 913 thick blood film examinations, the ParaSight-F test had 93.4% sensitivity and 98.2% specificity. Compared with 520 blood samples within the same study examined with the aid of the polymerase chain reaction, the ParaSight-F test had 91.6% sensitivity and 99.4% specificity. The ParaSight-F test could be a valuable diagnostic tool for falciparum malaria in any situation requiring rapid diagnosis in the absence of microscopical examination.

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