Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke

Åberg, Daniel; Jood, Katarina; Blomstrand, Christian; Jern, Christina; Nilsson, Michael; Isgaard, Jörgen; Åberg, N. David

doi:10.1210/jc.2010-2802

“…99 High serum levels of insulin-like growth factor 1 after stroke are associated with neurological recovery and better functional outcome. 100,101 In experimental stroke, insulin-like growth factor 1 treatment improved motor recovery, paralleled by enhanced neovascularization and neurogenesis. 102,103 However, because of its inability to pass through blood-brain barrier, insulin-like growth factor 1 was administered intranasally starting 10 minutes after stroke induction 102 or by adeno-associated virus-mediated gene transfer 3 weeks before stroke.…”

Section: Growth Factorsmentioning

confidence: 99%

Modulation of Neural Plasticity as a Basis for Stroke Rehabilitation

Pekna

¹

,

Pekny

²

,

Nilsson

³

2012

Stroke

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“…The design of Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) has been reported elsewhere (4,10). Briefly, patients (!70 years) with first-ever or recurrent acute IS were recruited consecutively at four Stroke Units in western Sweden between 1998 and 2008 (nZ844).…”

Section: Methodsmentioning

confidence: 99%

“…For the first 600 cases, data on functional outcome (modified Rankin Scale (mRS)) after 3 and 24 months or stroke severity (Scandinavian Stroke Scale (SSS)) acutely were available. From these subjects, s-IGF1 levels in 407 patients and in 40 randomly selected controls were available from a previous study (4). The s-IGF1s of these subjects were analyzed in 2008 in one series of experiments.…”

Section: Methodsmentioning

confidence: 99%

“…This study was approved by the Ethics Committee of the University of Gothenburg. Data and characteristics of each distinct subgroup of samples have been reported previously (4,10,11), and is also compiled in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…Specifically, serotonin reuptake inhibitors, which affects local brain IGF1 levels in experimental animals (1), also improve stroke outcome in humans (2). Furthermore, circulating serum IGF1 (s-IGF1) is associated with better recovery after ischemic stroke (IS) (3,4). Circulating s-IGF1 is regulated by growth hormone from the pituitary, but also by other factors such as age, metabolic state, and possibly physical activity (5,6).…”

Section: Introductionmentioning

confidence: 99%

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Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1

Åberg

¹

,

Olsson

²

,

Åberg

³

et al. 2013

European Journal of Endocrinology

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Objective: In humans, serum IGF1 (s-IGF1) is associated with outcome after ischemic stroke (IS). Therefore variation at the IGF1 locus could also associate with both IS and s-IGF1. We investigated whether genetic variation at the IGF1 locus is associated with i) s-IGF1, ii) IS occurrence, iii) IS severity, and iv) post-stroke outcome. Design/methods: Patients (nZ844; 66% males, mean age 56 years) and community controls (nZ668) were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Post-stroke outcome was evaluated with the modified Rankin Scale at 3 and 24 months after index stroke, and baseline stroke severity with the Scandinavian Stroke Scale. s-IGF1 was determined in patients and after random selection in 40 of the controls. Results: Eleven single nucleotide polymorphisms (SNPs) were selected in the IGF1 gene. In healthy controls the major allele of rs7136446 was associated with higher s-IGF1, whereas in patients no such association was found. No SNP was associated with IS, nor with stroke severity. After multivariate correction for presence of diabetes, smoking, and hypertension, the major allele of rs7136446 was associated with favorable functional outcome 24-months post-stroke (odds ratio 1.46; 95% CI 1.09-1.96). Conclusion: Variation in rs7136446 of the IGF1 gene associates with post-stroke outcome in relatively young IS patients. Also, rs7136446 associates with s-IGF1 in controls but not in IS, which indicates that IS perturbs a normal genetic impact on s-IGF1 levels.

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Plasma cyclic glycine proline/IGF‐1 ratio predicts clinical outcome and recovery in stroke patients

Fan

¹

,

Krishnamurthi

²

,

Harris

³

et al. 2019

Ann Clin Transl Neurol

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Objective Many stroke patients make a partial recovery in function during the first 3 months, partially through promoting insulin‐like growth factor‐1 ( IGF ‐1) function. A prognostic biomarker that associates with IGF ‐1 function may predict clinical outcome and recovery of stroke. This study evaluated plasma concentrations of IGF ‐1, IGF binding protein ( IGFBP )‐3 and cyclic‐glycine‐proline ( cGP ) and their associations with clinical outcome in stroke patients. Methods Thirty‐four patients were recruited within 3 days of stroke. Clinical assessments included the National Institutes of Health Stroke Scale ( NIHSS ) within 3 days (baseline), and at days 7 and 90; the modified Rankin Scale ( mRS ) and Fugl‐Meyer Upper‐Limb Assessment Scale ( FM ‐ UL ) at days 7 and 90. Plasma samples were collected from the patients at the baseline, days 7 and 90. Fifty age‐matched control participants with no history of stroke were also recruited and provided plasma samples. IGF ‐1, IGFBP ‐3, and cGP concentrations were analyzed using ELISA or HPLC ‐MS. Results Baseline concentrations of IGFBP ‐3, cGP , and cGP / IGF ‐1 ratio were lower in stroke patients than the control group. The neurological scores of stroke patients were improved and plasma cGP and cGP / IGF ‐1 ratio increased over time. Baseline cGP / IGF ‐1 ratio was correlated with the NIHSS scores at day 90 and the changes in NIHSS scores from the baseline to 90 days. Interpretation Low cGP concentrations and cGP / IGF ‐1 ratio in stroke patients suggest an impaired IGF ‐1 function. The cGP / IGF ‐1 ratio at admission maybe further developed as a prognostic biomarker for stroke recovery.

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Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke

Abstract: A high s-IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function.

Cited by 77 publications

References 25 publications

Modulation of Neural Plasticity as a Basis for Stroke Rehabilitation

Modulation of Neural Plasticity as a Basis for Stroke Rehabilitation

Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1

Plasma cyclic glycine proline/IGF‐1 ratio predicts clinical outcome and recovery in stroke patients

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