Serum IL-23 levels in patients with vitiligo

Cengiz, Fatma Pelin; Emiroğlu, Nazan; Cemil, Bengü Çevirgen; Erdem, Ümmü Gül Bahar; Kemeriz, Funda

doi:10.4274/turkderm.82957

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Another study identified lower serum IL‐23 levels in vitiligo patients compared to control, although this was not statistically significant. Both studies did not control for vitiligo type 61,62 …”

Section: Resultsmentioning

confidence: 99%

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A review of JAK and IL‐23 inhibitors to treat vitiligo

et al. 2023

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Vitiligo is an autoimmune skin disorder resulting in the depigmentation of skin characterised by patches of varying sizes and shapes. A common disorder of pigmentation that affects 0.5%–2% of the global population. Despite its well‐understood autoimmune pathogenesis, the targets for effective cytokine intervention remain unclear. Current first‐line treatments include oral or topical corticosteroids, calcineurin inhibitors and phototherapy. These treatments are limited, have varying efficacies, and are associated with significant adverse events or can be time‐consuming. Therefore, biologics should be explored as a potential treatment for vitiligo. There are currently limited data for the use of JAK and IL‐23 inhibitors for vitiligo. A total of 25 studies were identified in the review. There is promising evidence regarding the use of JAK and IL‐23 inhibitors for the treatment of vitiligo.

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Section: Resultsmentioning

confidence: 99%

“…Both studies did not control for vitiligo type. 61,62 There have been several cases of successful treatment of vitiligo with IL-23 inhibitors. A total of six studies involved IL-23 inhibitors.…”

Section: Interleukin-23 Biologicsmentioning

confidence: 99%

A review of JAK and IL‐23 inhibitors to treat vitiligo

et al. 2023

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“…Although the definite cause of the ailment has not yet been determined, a number of theories linking it with autoimmune, cytotoxic, biochemical, neural, and oxidant-antioxidant mechanisms have been proposed. The role of viruses and genetics has also been looked into while studying the disease [ 1 , 2 ]. Vitiligo patients display increased oxidative stress in blood as well as epidermis [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Dynamic thiol/disulphide homeostasis in vitiligo patients

Aksoy

Çelik

2018

pdia

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IntroductionVitiligo is an acquired depigmentation disorder with melanocyte destruction.AimTo examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group.Material and methodsThirty-two patients with vitiligo and 35 healthy individuals were included in the study. Native thiol, disulfide and total thiol levels in plasma were evaluated using a new and automated spectrophotometric method. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured.ResultsThere was no statistically significant difference between the two groups when the patient and control groups were compared in terms of thiol/disulphide balance (p > 0.05). There was no statistically significant difference in native thiol, disulphide and total thiol levels for vitiligo when compared with the control group (p > 0.005).ConclusionsIn recent years, there have been numerous studies on the role of oxidative stress in the etiopathogenesis of vitiligo. In this study, we investigated in vitiligo patients whether thiol/disulphide balance is a new oxidative stress marker. The results were compared with a healthy control group. We measured the thiol/disulphide balance by a new method developed by Erel and Neselioglu. The serum thiol/disulphide levels were similar in the vitiligo patients and the control subjects, which indicated that the thiol/disulphide balance was not affected by vitiligo. We are of the opinion that new investigations to determine serum levels of thiol/disulphide may shed light on the possible roles of these molecules in vitiligo.

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