Serum IL‐6 Level and the Development of Disability in Older Persons

Ferrucci, Luigi; Harris, Tamara B.; Guralnik, Jack M.; Tracy, Russell P.; Corti, Maria Chiara; Cohen, Harvey Jay; Penninx, Brenda W. H. J.; Pahor, Marco; Wallace, Robert B.; Havlik, Richard J.

doi:10.1111/j.1532-5415.1999.tb01583.x

Cited by 746 publications

(563 citation statements)

References 48 publications

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“…Until today, only a limited number of prospective population studies further reported on the positive association between IL-6 and physical decline in older individuals. However, these previous studies were all restricted to lower age categories (Ferrucci et al 2002;Schaap et al 2009;Penninx et al 2004;Stenholm et al 2010;Taaffe et al 2000), highfunctioning persons (Schaap et al 2009;Penninx et al 2004;Taaffe et al 2000;Ferrucci et al 1999), or longer follow-up periods (Schaap et al 2009;Stenholm et al 2010;Taaffe et al 2000;Ferrucci et al 1999) or were gender-specific (Ferrucci et al 2002). Therefore, the generalizability of these findings in the oldest old might be limited.…”

Section: Discussionmentioning

confidence: 97%

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Adriaensen

Matheï

Vaes

et al. 2014

AGE

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The chronic inflammatory state at old age may contribute to the pathophysiology of or reflect chronic conditions resulting in loss of physical and mental functioning. Therefore, our objective was to examine the predictive value of a large battery of serum inflammatory markers as risk indicators for global functional decline and its specific physical and mental determinants in the oldest old. Global functional decline and specific aspects of physical and mental functional decline were assessed during an average of 1.66 years (±0.21) in a sample of 303 persons aged 80 years or older of the BELFRAIL study. Serum levels of 14 inflammatory proteins, including cytokines, growth factors, and acute phase proteins, were measured at baseline. Almost 20 % of the participants had a significant global functional decline over time. Interleukin (IL)-6 serum levels were uniquely positively associated with global functional decline, even after correcting for multiple confounders (odds ratio 1.51). Odds ratios for the individual aspects (physical dependency, physical performance, cognition, and depression) of functioning were lower, and composite scores of physical or mental decline were not significant. The proportion of global functional decline exhibited a dose-response curve with increasing levels of IL-6. Thus, IL-6 is an independent risk indicator for accelerated global functional decline in the oldest old. Our results suggest that simple serum levels of IL-6 may be very useful in short-term identification or evaluation of global functional status in the oldest old.

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Section: Discussionmentioning

confidence: 97%

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Adriaensen

Matheï

Vaes

et al. 2014

AGE

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“…Since subclinical inflammation increases the risk of cardiovascular disease, disability, neurodegenerative disorders and cancers [20][21][22][23][24], it is important to identify efficient ways to modulate low-grade immune activation. Lifestylebased interventions are one option as they have been proved to exert anti-inflammatory effects in many studies [17,32].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to type 2 diabetes, subclinical inflammation is also a risk factor for cardiovascular disease, neurodegenerative disorders, depression and some cancers [20][21][22][23][24], which means that the identification of the mechanisms that modulate and attenuate systemic immune activation has widespread implications.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study

Peltonen²,

et al. 2009

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Aims/hypothesis Subclinical inflammation confers an increased risk of type 2 diabetes, cardiovascular disease, neurodegenerative disorders and other age-related chronic diseases. Physical activity and diet can attenuate systemic immune activation, but it is not known which individual components of a comprehensive lifestyle intervention are most effective in targeting subclinical inflammation.Methods We used data from the baseline examination and the 1 year follow-up of a subsample of 406 of 522 participants of the Finnish Diabetes Prevention Study (DPS) to estimate the effect of individual components of lifestyle intervention on C-reactive protein (CRP) and IL-6 levels, which represent the best characterised proinflammatory risk factors for type 2 diabetes. Changes in metabolic markers, dietary patterns and exercise were analysed to Diabetologia (2009) determine which were most strongly associated with the anti-inflammatory effect of lifestyle changes. Results Lifestyle intervention reduced circulating levels of CRP (p<0.001) and . Increases in fibre intake and moderate to vigorous leisure time physical activity (LTPA), but not total LTPA, predicted decreases in CRP and/or IL-6 and remained associated even after adjustment for baseline BMI or changes in BMI during the first year of the study. Changes in carbohydrate or fat intake were either weakly or not linked to reductions in CRP and IL-6. Conclusions/interpretation The present study assessed the individual effects of dietary and physical activity measures on low-grade inflammation in individuals at high cardiometabolic risk. Our results underline the importance of moderate to vigorous LTPA and a diet rich in natural fibre, and this should be emphasised in lifestyle recommendations.

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“…An evolving definition of inflammation in gerontology is low-grade activation of the innate immune system, leading to chronic production of inflammatory mediators. Inflammatory processes in general have been implicated as predictors of or contributors to chronic diseases and conditions of aging (117), such as cardiovascular disease (118), low cognitive performance (119), osteoarthritis and dementia (120), frailty (121,122), muscle wasting (123), physical performance (123,124), disability (125,126) and mortality (127)(128)(129). These associations have been…”

Section: The Biological Explanationmentioning

confidence: 99%

Fatigue in older adults: an early indicator of the aging process?

2010

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Serum IL‐6 Level and the Development of Disability in Older Persons

Abstract: Higher circulating levels of IL-6 predict disability onset in older persons. This may be attributable to a direct effect of IL-6 on muscle atrophy and/or to the pathophysiologic role played by IL-6 in specific diseases.

Cited by 746 publications

References 48 publications

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study

Fatigue in older adults: an early indicator of the aging process?

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