Serum Immunoglobulin E in Idiopathic Nephrotic Syndrome

Mishra, Om P.; Ibrahim, Nesma Ali; Usha, .; Das, Biswadeep

doi:10.1093/tropej/50.3.149

Cited by 14 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2,3 In many studies, increased incidence of allergic diseases and high serum IgE levels have been reported in SSNS. 2,[4][5][6]9,[16][17][18][19] These findings support the existence of a dysfunction of the humoral immune response in the nephrotic syndrome. 4,6,7,18,19 The term ''atopy'' is used to define IgE-mediated diseases.…”

Section: Discussionsupporting

confidence: 56%

“…2,[4][5][6]9,[16][17][18][19] These findings support the existence of a dysfunction of the humoral immune response in the nephrotic syndrome. 4,6,7,18,19 The term ''atopy'' is used to define IgE-mediated diseases. Atopic individuals are genetically sensitive toward widespread allergens and produce IgE antibodies; cytokines like IL-4 and IL-13 produced by T helper 2 (Th-2) cells.…”

Section: Discussionsupporting

confidence: 56%

See 1 more Smart Citation

Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies

et al. 2015

View full text Add to dashboard Cite

Background: The etiology of minimal-change disease is not fully known, it is believed to be mediated by the immune system. Minimal-change disease also reported as having association with atopy. In this study, atopy history, the levels of serum IgE, and skin prick test in children with steroid-sensitive nephrotic syndrome were investigated. Methods: A group of 30 children (mean age 7.7 ± 2.2 years, 56.6% male) diagnosed with steroid-sensitive nephrotic syndrome were included in the study. Serum immunoglobulin E levels and eosinophil counts were evaluated in children with steroid-sensitive nephrotic syndrome both in relapse and remission. Skin prick test was performed in remission. Results: Of the 30 children investigated, 11 (36.7%) had a history of atopy. The median serum total IgE levels in nephrotic children in relapse, with (445 IU/mL) and without atopy (310 IU/mL) were significantly higher than those in remission (respectively, 200 IU/mL, p ¼ 0.021, and 42 IU/mL, p ¼ 0.001). The skin prick tests for all the allergens were evaluated as negative in all the patients. Conclusion: It was thought that increased IgE may reflect the activation of immune mechanism following various stimuli rather than a direct association with atopy in children with steroid-sensitive nephrotic syndrome.

show abstract

Section: Discussionsupporting

confidence: 56%

Section: Discussionsupporting

confidence: 56%

Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In recent years, studies have reported that increased serum IgE concentrations in patients with NS were closely associated with NS and allergic disorders. [6][7][8]28,31 The synthesis of IgE is mainly mediated by two cytokines, interleukin (IL)-4 and IL-13, released by T-helper 2 (Th2) cells. 32 Increased concentrations of IL-4 and IL-13 have been reported in children with NS.…”

Section: Discussionmentioning

confidence: 99%

Elevation of plasma-soluble HLA-G in childhood nephrotic syndrome is associated with IgE

et al. 2016

View full text Add to dashboard Cite

Background Nephrotic syndrome is related to immune system dysfunction. Soluble human leukocyte antigen-G has been suggested to have an immunomodulatory role. Additionally, human leukocyte antigen-G expression may be influenced by the 14-base pair insertion/deletion polymorphism. However, this molecule has not been investigated in nephrotic syndrome. Methods Fifty-five children with nephrotic syndrome were enrolled: 24 primary nephrotic syndrome patients and 31 recurrent nephrotic syndrome patients. A group of 120 healthy subjects were included as reference controls. Additionally, 22 patients in nephrotic syndrome remission after treatments were also included. Both nephrotic syndrome patients and healthy subjects were genotyped for the 14-base pair insertion/deletion polymorphism. Plasma soluble human leukocyte antigen-G concentrations and serum immunoglobulin concentrations were determined. Results Nephrotic syndrome patients showed significantly higher levels of both soluble human leukocyte antigen-G and immunoglobulin E compared to normal controls. Nephrotic syndrome patients presented a higher frequency of the -14-base pair allele than did normal controls. Soluble human leukocyte antigen-G concentrations in remission patients were dramatically lower compared to in nephrotic syndrome patients. Moreover, soluble human leukocyte antigen-G and immunoglobulin E were moderately correlated in nephrotic syndrome patients. Conclusions The present study demonstrated that plasma soluble human leukocyte antigen-G concentrations were significantly elevated and that a relationship between serum total immunoglobulin E in nephrotic syndrome patients and the human leukocyte antigen-G -14-base pair allele may be a risk factor for nephrotic syndrome. These findings suggest that soluble human leukocyte antigen-G may be used as a monitoring marker for nephrotic syndrome patients' condition.

show abstract

“…Most,13-15,18,22,25-28 but not all,17,29 studies have reported greater serum IgE levels in patients with MCD compared with controls. Not infrequently, increased IgE levels occur in the absence of other clinical findings of atopy 13,16.…”

Section: Atopymentioning

confidence: 97%

Idiopathic Nephrotic Syndrome and Atopy: Is There a Common Link?

Abdel-Hafez

Shimada

Lee

et al. 2009

American Journal of Kidney Diseases

116

108

View full text Add to dashboard Cite

Numerous reports during the last 60 years have reported a strong association between idiopathic nephrotic syndrome and atopic disorders. Idiopathic nephrotic syndrome can be precipitated by allergic reactions and has been associated with both aeroallergens (pollens, mold, and dust) and food allergies. Patients with idiopathic nephrotic syndrome also may show increased serum immunoglobulin E (IgE) levels. A review of the literature suggests that although some idiopathic nephrotic syndrome cases may be associated with allergies, evidence that it is a type of allergic disorder or can be induced by a specific allergen is weak. Rather, it is likely that the proteinuria and increased IgE levels in patients with idiopathic nephrotic syndrome are caused by increased levels of interleukin 13 observed in these patients. Recent studies suggest that interleukin 13, a known stimulator of IgE response, may mediate proteinuria in patients with minimal change disease because of its ability to directly induce CD80 expression on the podocyte. KeywordsAtopy; nephrotic syndrome; minimal change disease Idiopathic nephrotic syndrome in children is a clinical syndrome associated with a variety of glomerular lesions. Minimal change disease (MCD) is the most common cause of idiopathic nephrotic syndrome. MCD is often abrupt in onset. It can be dramatic in presentation, yet is one of the most rewarding diseases for a physician to manage because response to corticosteroids often is rapid and complete. Because kidney biopsy usually is not performed when the disease responds to corticosteroid therapy, the term MCD has become synonymous with steroid-sensitive nephrotic syndrome. The mechanism(s) underlying the MCD pathogenesis are unknown, although it is believed to be immunologically mediated. 1 Strong evidence suggests that it may be caused by a circulating factor, possibly T-cell related, that causes podocyte dysfunction resulting in massive proteinuria. 2 However, there also have been numerous reports linking MCD with atopic disorders and increases in serum immunoglobulin E (IgE) levels. In this review, we discuss the evidence supporting the association of atopy and whether there may be a common underlying immune disorder that may predispose patients to both conditions. ATOPYAtopy is a term used to describe IgE-mediated diseases. Persons with atopy have a hereditary predisposition to produce IgE antibodies to common allergens and often manifest with 1 or more atopic diseases (asthma, allergic rhinitis, and atopic eczema). Atopic patients mount an exaggerated immunologic response characterized by production of allergen-specific IgE antibodies and positive reactions to extracts of common aeroallergens on skin-prick tests. Type 2 helper T cells (T H 2) from patients with atopy respond to allergens in vitro by expressing such cytokines as interleukin 4 (IL-4) and IL-13 3 (Fig 1A and B). Early Reports of Atopy With MCDIn 1951, Fanconi et al 4 were among of the first to associate atopy and nephrotic syndrome. Forty-three percent of th...

show abstract

Serum Immunoglobulin E in Idiopathic Nephrotic Syndrome

Cited by 14 publications

References 0 publications

Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies

Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies

Elevation of plasma-soluble HLA-G in childhood nephrotic syndrome is associated with IgE

Idiopathic Nephrotic Syndrome and Atopy: Is There a Common Link?

Contact Info

Product

Resources

About