Serum Inhibin B in Healthy Pubertal and Adolescent Boys: Relation to Age, Stage of Puberty, and Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Estradiol Levels1

Andersson, Anna‐Maria; Juul, Anders; Petersen, Jørgen; Müller, Jørn; Groome, Nigel P.; Skakkebæk, Niels E.

doi:10.1210/jcem.82.12.4449

Cited by 88 publications

(13 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AR is not expressed in germ cells, but a lack of AR in Leydig cells has a major influence on the steroidogenic function and results in a spermatogenic arrest at the stage of round spermatids. In terms of spermatogenic outcome, inhibin B directly correlates with sperm counts [62]. In addition to inhibin B, AMH is another crucial factor for Sertoli cell maturation, testicular formation and germ cell differentiation [49].…”

Section: Reasons For Failure Of Human Male Germ Cell Developmentmentioning

confidence: 99%

Male Germ Cell Development in Humans

et al. 2013

View full text Add to dashboard Cite

Background: Germ cells are unique cells that possess the ability to transmit genetic information between generations. Detailed knowledge about the molecular and cellular mechanisms determining the fate of human male germ cells still remains sparse. This is partially due to ethical issues limiting the access to research material. Therefore, the mechanisms of proliferation, differentiation and apoptosis of human male germ cells still remain challenging study objectives. Methods: This review focuses on using English articles accessible in PubMed as well as personal files on the current knowledge of the molecular and cellular mechanisms connected with human testicular germ cell development, maturation failure and the possibility of fertility preservation in patients in whom there is a risk of gonadal failure. However, since rodents, particularly mice, offer the possibility of studying germ cell development by use of genetic modification techniques, some studies using animal models are also discussed. Conclusion: This mini review focuses on the current knowledge about male germ cells. However, the reader is referred to two previous mini reviews focusing on testicular somatic cells, i.e. on Sertoli cells and Leydig cells.

show abstract

Section: Reasons For Failure Of Human Male Germ Cell Developmentmentioning

confidence: 99%

Male Germ Cell Development in Humans

et al. 2013

View full text Add to dashboard Cite

show abstract

“…It was proposed that serum inhibin B is positively correlated with function of Sertoli cells as well as spermatogenesis. [20] In our report, we observed a positive association between inhibin B levels and acrylamide exposure (HbAA). However, we did not observed association between acrylamide exposure and testosterone level.…”

Section: Plos Onementioning

confidence: 60%

Association between acrylamide exposure and sex hormones in males: NHANES, 2003–2004

et al. 2020

View full text Add to dashboard Cite

Introduction Acrylamide is widely present in heat-processed food, cigarette smoke and environment. Reproductive toxicity was reported in animals treated with acrylamide, particularly in males. The reproductive toxicity of acrylamide and its active metabolite, glycidamide, was reported to be mainly mediated through DNA damage in spermatocytes. However, the effect of acrylamide on sex hormones in men is unknown. Methods There were 468 male subjects (age ≧ 12 years) enrolled to determine the relationships between hemoglobin adducts of acrylamide (HbAA) and hemoglobin adducts of glycidamide (HbGA) with several sex hormones using the National Health and Nutrition Examination Survey (NHANES), 2003 to 2004. All potential confounding variables in the data set were properly adjusted. Results We found that one unit increase in the natural log-transformed HbAA level was associated with an increase in natural log transformed serum inhibin B level by 0.10 (SE = 0.05; P = 0.046), and natural log transformed serum sex hormone binding globulin (SHBG) by 0.15 (SE = 0.15; P = 0.036). With respect to HbGA, one unit increase in the natural log-transformed HbGA level was associated with an increase in natural log transformed serum anti-Mü llerian Hormone (AMH) level by 0.31 (SE = 0.00; P = 0.003). Conclusion In this representative cohort, we identified positive associations between acrylamide exposure and several sex hormones in men. The HbAA is positively associated with inhibin B and SHBG, and HbGA is positively associated with AMH. Other than genotoxicity, our

show abstract

“…At midpuberty, maturational changes in the negative feedback regulation of the HPG axis occur and persist into adulthood. In this process, estradiol is likely to play an important role (68). Therefore, it has been proposed that estrogen administration to boys during early and midpuberty would decrease serum LH concentration and LH pulse frequency but would have no effect on LH pulse amplitude (69).…”

Section: Role Of Estrogens In Gonadotropin and Testicular Physiology mentioning

confidence: 99%

Estrogens in Human Male Gonadotropin Secretion and Testicular Physiology From Infancy to Late Puberty

et al. 2020

View full text Add to dashboard Cite

Several reports in humans as well as transgenic mouse models have shown that estrogens play an important role in male reproduction and fertility. Estrogen receptor alpha (ERα) and beta (ERβ) are expressed in different male tissues including the brain. The estradiol-binding protein GPER1 also mediates estrogen action in target tissues. In human testes a minimal ERα expression during prepuberty along with a marked pubertal up-regulation in germ cells has been reported. ERβ expression was detected mostly in spermatogonia, primary spermatocytes, and immature spermatids. In Sertoli cells ERβ expression increases with age. The aromatase enzyme (cP450arom), which converts androgens to estrogens, is widely expressed in human tissues (including gonads and hypothalamus), even during fetal life, suggesting that estrogens are also involved in human fetal physiology. Moreover, cP450arom is expressed in the early postnatal testicular Leydig cells and spermatogonia. Even though the aromatase complex is required for estrogen synthesis, its biological relevance is also related to the regulation of the balance between androgens and estrogens in different tissues. Knockout mouse models of aromatase (ArKO) and estrogen receptors (ERKOα, ERKOβ, and ERKOαβ) provide an important tool to study the effects of estrogens on the male reproductive physiology including the gonadal axis. High basal serum FSH levels were reported in adult aromatase-deficient men, suggesting that estrogens are involved in the negative regulatory gonadotropin feedback. However, normal serum gonadotropin levels were observed in an aromatase-deficient boy, suggesting a maturational pattern role of estrogen in the regulation of gonadotropin secretion. Nevertheless, the role of estrogens in primate testis development and function is controversial and poorly understood. This review addresses the role of estrogens in gonadotropin secretion and testicular physiology in male humans especially during childhood and puberty.

show abstract

Serum Inhibin B in Healthy Pubertal and Adolescent Boys: Relation to Age, Stage of Puberty, and Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Estradiol Levels1

Cited by 88 publications

References 44 publications

Male Germ Cell Development in Humans

Male Germ Cell Development in Humans

Association between acrylamide exposure and sex hormones in males: NHANES, 2003–2004

Estrogens in Human Male Gonadotropin Secretion and Testicular Physiology From Infancy to Late Puberty

Contact Info

Product

Resources

About