Serum Inhibin Concentrations Rise Throughout Normal Male and Female Puberty*

Burger, Henry; McLachlan, Robert I; Bangah, Mohan; Quigg, Helen; Findlay, Jock K.; Robertson, David; Kretser, David Morritz de; Warne, Gary L.; Werther, George A.; Hudson, Irene L.; Cook, Jennifer; Fiedler, R; Greco, Santo; Yong, A. B. W.; Smith, Paul J.

doi:10.1210/jcem-67-4-689

Cited by 68 publications

(13 citation statements)

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“…This is a similar pattern to that reported previously in rams (Schanbacher 1988, Isaacs et al 1995 and in bulls (Miyamoto et al 1989, MacDonald et al 1991 and male rats (Crofton et al 1997) but is different to that found in male monkeys (Keeping et al 1990, Marson et al 1993 and boys (Burger et al 1988, Crofton et al 1997. Nonetheless, a recent study in boys using a specific assay for inhibin B has shown that levels of this hormone are high in the first year of life (Andersson et al 1997).…”

Section: Discussionsupporting

confidence: 87%

“…The testes of prepubertal males synthesize and secrete significant amounts of inhibin and the pattern of secretion of inhibin changes during sexual development although there appears to be substantial differences between species. For example, circulating concentrations of inhibin during sexual maturation have been found to increase in male monkeys (Keeping et al 1990, Marson et al 1993) and in boys (Burger et al 1988, Crofton et al 1997 but to decrease in male rats (Wreford et al 1994), bulls (Miyamoto et al 1989, MacDonald et al 1991 and rams (Schanbacher 1988, Isaacs et al 1995. Several studies indicate that a functional negative feedback system between inhibin and FSH exists before puberty as shown by the decrease in plasma concentrations of inhibin and an increase in FSH in 1-week-old ram lambs (Schanbacher 1988), and the demonstration that active immunization against inhibin in prepubertal ram lambs (Al-Obaidi et al 1987) and bull calves (Martin et al 1991, Schanbacher 1991 caused an increase in plasma concentrations of FSH.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin

Tilbrook

Kretser

Clarke³

1999

Journal of Endocrinology

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We have investigated the effectiveness of human recombinant inhibin A (hr-inhibin A) to suppress the secretion of follicle-stimulating hormone (FSH) in ram lambs from 1 to 18 months of age. Seventeen rams (nine castrated, eight intact) were used. At 1, 3, 6, 9, 12 and 18 months of age the rams were given an i.v. injection of either vehicle or hr-inhibin A (0·64 µg/kg). Blood samples were taken over 24 h. Plasma concentrations of FSH were suppressed in castrated and intact rams following injection of hr-inhibin A with maximal suppression occurring 6 h after injection. Vehicle injection had no effect. At 12 months of age the suppression in FSH was most rapid in castrated rams and was maximal in intact rams. The clearance rate of inhibin was greatest at older ages but during the period of seasonally induced testicular activity, there was a significant decrease in the inhibin clearance. The testicular weight was reduced in rams treated with hr-inhibin A, indicating the importance of FSH for testicular development during the pubertal period. There was no effect of hr-inhibin A on plasma concentrations of luteinizing hormone. We conclude that inhibin is capable of suppressing the secretion of FSH in rams from 1 month of age onwards and that the pituitary gland becomes maximally responsive to the actions of inhibin by the age of puberty.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin

Tilbrook

Kretser

Clarke³

1999

Journal of Endocrinology

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“…FSH concentrations in the subjects we studied did not rise to the same extent as those of LH in late puberty. This may reflect gradual suppression by increasing levels of inhibin during pubertal development (Burger, McLachlan, Bangah et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Evidence for temporal coupling of growth hormone, prolactin, LH and FSH pulsatility overnight during normal puberty

Dunger¹,

Matthews²,

Edge³

et al. 1991

Journal of Endocrinology

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The patterns of secretion of GH, LH, FSH and prolactin were determined over a single night (20.00-08.00 h; 15-min sampling) in 34 normal subjects (17 male, 17 female, aged 9.1-20.9 years). Plasma GH was measured by an immunoradiometric assay and LH, FSH and prolactin by radioimmunoassay in all samples. Data were analysed by Fourier transformation and cross-correlation after stationarization. The highest mean GH levels were noted in girls at Tanner stage 2/3 and in boys at stages 4/5. Prolactin levels were highest in girls at stage 4/5 and in boys at stage 2/3. LH and FSH showed a progressive rise by puberty stage in both sexes. The dominant pulse periodicities of GH and prolactin were 150-180 min in girls and 180 min in boys. LH and FSH pulse periodicity was around 90 min in early puberty and 180 min in later puberty in both sexes. LH and prolactin pulses showed a phase relationship with GH with a lag of 30-75 min (r = 0.32; P less than 0.001) and 30 min (r = 0.47; P less than 0.0001) respectively. Generally, LH and prolactin pulses were in phase (r = 0.42; P less than 0.0001) and there was a highly significant correlation (r = 0.64; P less than 0.0001) between FSH and LH pulsatility. Whereas mean overnight concentrations and pulse periodicity of the principal pituitary hormones varied between the sexes during early puberty, by the end of puberty a dominant pulse periodicity of around 150-180 min was established and there was remarkable temporal coupling of pulsatility.

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“…(J Clin Endocrinol Metab 82: 3976 -3981, 1997) T HE ONSET of male puberty is associated with alterations in the circulating concentrations of gonadotropins and gonadal hormones, including a rise in the levels of the gonadal glycoprotein inhibin (1,2). The correlation of inhibin B to FSH, LH, and testosterone changes during pubertal development.…”

mentioning

confidence: 99%

“…The positive correlation between inhibin B and LH/ testosterone at the time when serum inhibin B levels rise early in puberty suggests that Leydig cell factors may play an important role in the maturation and stimulation of Sertoli cells in the beginning of pubertal development. Previous studies of inhibin during puberty, in which the earlier unspecific assays were used, failed to demonstrate a correlation between inhibin and FSH in prepubertal and pubertal boys (1,14). Several circulating inhibin forms exist, some of which are believed to be biologically inactive (3).…”

mentioning

confidence: 99%

Serum Inhibin B in Healthy Pubertal and Adolescent Boys: Relation to Age, Stage of Puberty, and Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Estradiol Levels1

Andersson

Juul

Petersen³

et al. 1997

The Journal of Clinical Endocrinology &Amp; Metabolism

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Inhibin B levels were measured in serum from 400 healthy Danish prepubertal, pubertal, and adolescent males, aged 6-20 yr, in a cross-sectional study using a recently developed immunoassay that is specific for inhibin B, the physiologically important inhibin form in men. In addition, serum levels of FSH, LH, testosterone, and estradiol levels were measured. Serum levels of inhibin B, FSH, LH, testosterone, and estradiol all increased significantly between stages I and II of puberty. From stage II of puberty the inhibin B level was relatively constant, whereas the FSH level continued to increase between stages II and III. From stage III of puberty the FSH level was also relatively constant, although there was a nonsignificant trend of slightly decreased FSH levels at pubertal stage V compared to stage IV. The levels of serum LH, testosterone, and estradiol increased progressively throughout puberty. In prepubertal boys younger than 9 yr, there were no correlation between inhibin B and the other three hormones. In prepubertal boys older than 9 yr, a significant positive correlation was observed between inhibin B and FSH, LH, and testosterone. However, at this pubertal stage, each hormone correlated strongly with age, and when the effect of age was taken into account, only the partial correlation between inhibin B and LH/testosterone remained statistically significant. At stage II of puberty, the positive partial correlation between inhibin B and LH/testosterone was still present. At stage III of puberty, an negative partial correlation between inhibin B and FSH, LH, and estradiol was present, whereas no correlation between inhibin B and testosterone could be observed from stage III onward. The negative correlation between inhibin B and FSH persisted from stage III of puberty onward, whereas the correlation between inhibin B and LH and between inhibin B and estradiol was nonsignificant at stages IV and V of puberty. In conclusion, in boys, serum inhibin B levels increase early in puberty; by pubertal stage II the adult level of inhibin B has been reached. The correlation of inhibin B to FSH, LH, and testosterone changes during pubertal development. Early puberty is characterized by a positive correlation between inhibin B and LH/testosterone, but no correlation to FSH. Late puberty (from stage III) is characterized by a negative correlation between inhibin B and FSH (which is maintained in adult men), a diminishing negative correlation between inhibin B and LH, and no correlation between inhibin B and testosterone, suggesting that developmental and maturational processes in the hypothalamic-pituitary-gonadal axis take place, leading to the establishment of the closed loop feedback regulation system operating in adult men. The positive correlation between inhibin B and LH/ testosterone at the time when serum inhibin B levels rise early in puberty suggests that Leydig cell factors may play an important role in the maturation and stimulation of Sertoli cells in the beginning of pubertal development.

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Serum Inhibin Concentrations Rise Throughout Normal Male and Female Puberty*

Cited by 68 publications

References 0 publications

Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin

Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin

Evidence for temporal coupling of growth hormone, prolactin, LH and FSH pulsatility overnight during normal puberty

Serum Inhibin B in Healthy Pubertal and Adolescent Boys: Relation to Age, Stage of Puberty, and Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Estradiol Levels1

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