Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia

Sira, Mostafa Mohamed; Behairy, Behairy E.; Abdel-Aziz, Azza; Elnaby, Sameh A. Abd; Eltahan, Ehab E.

doi:10.1155/2014/307942

Cited by 21 publications

(21 citation statements)

References 46 publications

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“…Research by other authors shows that ITIH4 may also have potential antiviral properties against chronic hepatitis C virus. Sira et al (2014) found that hepatitis C viremia was lower in patients with higher serum ITIH4 levels. Previous studies indicate that ITIH4 play a particularly important role not only in inflammation but also in carcinogenesis.…”

Section: Discussionmentioning

confidence: 94%

Acute-phase inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) levels in serum and milk of cows with subclinical mastitis caused by Streptococcus species and coagulase-negative Staphylococcus species

Soler

Dąbrowski

García

et al. 2019

Journal of Dairy Science

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The aim of the study was to investigate the concentrations of acute-phase inter-α-trypsin inhibitor heavy chain 4 (ITIH4) in serum and milk of cows with subclinical mastitis caused by Streptococcus spp. (STR) and coagulase-negative Staphylococcus spp. (CNS) and healthy cows. The blood and milk samples were obtained from 60 mid-lactation, multiparous Holstein-Friesian cows from 7 herds in the Lublin region of Poland. In the milk samples from 40 cows with subclinical mastitis, Streptococcus spp. and CNS were isolated. The ITIH4 was significantly higher in serum of cows with subclinical mastitis caused both by STR and CNS compared with healthy cows. One hundred percent of animals infected with Streptococcus spp. and 89% of animals infected with Staphylococcus spp. showed ITIH4 concentration in sera higher than 0.5 mg/mL. The concentration of ITIH4 in milk also was significantly higher in cows with subclinical mastitis caused by Streptococcus spp. and Staphylococcus spp. compared with the control group. Seventy percent of cows infected by STR and CNS showed ITIH4 concentration in milk higher than 2.5 μg/mL. Milk ITIH4 concentration higher than 5 μg/mL was found in 55% of animals infected with Streptococcus spp. and in 40% of animals infected with Staphylococcus spp. No statistically significant differences were observed in ITIH4 concentrations both in serum and in milk between the studied unhealthy animal groups. These results suggest that ITIH4 may be used in the future as a novel diagnostic marker in serum and in milk of subclinical mastitis in cows.

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Section: Discussionmentioning

confidence: 94%

Acute-phase inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) levels in serum and milk of cows with subclinical mastitis caused by Streptococcus species and coagulase-negative Staphylococcus species

Soler

Dąbrowski

García

et al. 2019

Journal of Dairy Science

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“…We are constantly searching for new, more specific markers of liver fibrosis. A single study conducted in CHC children tested the significance of markers such as the C4a Complement[ 70 ] and inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4)[ 71 ], which was not associated with liver fibrosis scores but could predict significant fibrosis. The results of a recent study indicated that the non-invasive biomarkers APRI, FIB-4 and AST modified by the body mass index z-score have a good to excellent performance for detecting significant liver fibrosis[ 72 ].…”

Section: Serum Biomarker Testsmentioning

confidence: 99%

Hepatitis C virus infection in children in the era of direct-acting antiviral

Pawłowska

Sobolewska-Pilarczyk

Domagalski

2018

WJG

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Hepatitis C virus (HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral (DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising. In this era, the identification and monitoring of patients continues to be an important issue. The availability of non-invasive serological and imaging methods to measure hepatic fibrosis enables the identification of patients with significant or advanced liver fibrosis stages. This article summarizes the current data on the epidemiology and progress of research aimed to evaluate the new therapies and non-invasive methods for liver injury in paediatric patients with chronic hepatitis C.

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“…We have previously studied other serological non-invasive markers such as serum complement C4a [35] and serum interalpha-trypsin inhibitor heavy chain 4 [36] in children with chronic HCV. It can be concluded that none of these markers alone can reach an accurate prediction of liver fi brosis.…”

Section: Ykl-40 Is An Emerging New Infl Ammation Biomarkermentioning

confidence: 99%

Serum YKL-40 (Chitinase-3-Like Protein 1) Compared to APRI and FIB-4 in Predicting Liver Fibrosis in Children with Chronic Hepatitis C

Sira¹,

El-Araby²,

Ghoneim³

et al. 2016

Arch Hepat Res

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Background: Liver fi brosis is a critical factor for the treatment policy and its outcome in chronic hepatitis C virus (HCV) infection. Although liver biopsy represents the gold standard for evaluating fi brosis, it remains an invasive procedure with inherent risks. Thus, it cannot be performed frequently to monitor therapeutic outcomes specially in the pediatric population. For that, developing a non-invasive test that can predict liver fi brosis represents a growing medical need. Objectives: to investigate serum levels of YKL-40 and their relation to liver fi brosis in children with chronic HCV. Methods: Serum YKL-40 was measured by enzyme linked immunosorbent assay in 40 treatmentnaive children with proved chronic HCV and the levels were compared according to different laboratory and histopathological parameters. Liver histopathological changes were assessed using Ishak score and compared with aspartate transaminase-to-platelet ratio (APRI) and fi brosis-4 (FIB-4) indices as simple non-invasive markers of fi brosis. YKL-40 was measured in a group of 27 age-and sex-matched healthy controls. Results: YKL-40 was signifi cantly higher in patients than in controls (23.79±11.59 ng/ml vs. 17.67±5.49 ng/ml; P = 0.038). YKL-40 (r = 0.36, P = 0.022), but not APRI (r =-0.176, P = 0.328) or FIB-4 (r =-0.202, P = 0.259), had a signifi cant direct correlation with fi brosis stage. YKL-40 at a cutoff level of ≥24.82 ng/ml could discriminate patients with signifi cant fi brosis (≥F3 Ishak) with 100% sensitivity and 80% specifi city. Conclusion: YKL-40 signifi cantly correlated with liver fi brosis and could discriminate those with signifi cant fi brosis with acceptable performance.

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Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia

Cited by 21 publications

References 46 publications

Acute-phase inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) levels in serum and milk of cows with subclinical mastitis caused by Streptococcus species and coagulase-negative Staphylococcus species

Acute-phase inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) levels in serum and milk of cows with subclinical mastitis caused by Streptococcus species and coagulase-negative Staphylococcus species

Hepatitis C virus infection in children in the era of direct-acting antiviral

Serum YKL-40 (Chitinase-3-Like Protein 1) Compared to APRI and FIB-4 in Predicting Liver Fibrosis in Children with Chronic Hepatitis C

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