Serum Interleukin 17 Levels in Patients with Crohn’s Disease: Real Life Data

Abstract

The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn's disease activity was calculated using Crohn's disease activity index (CDAI). Results. The mean serum IL17 level of CD patients did not differ from those of healthy controls (P > 0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P > 0.05). However, the mean IL17 level of active patients was lower than of control subjects (P = 0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI. Conclusions. Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn's disease which is understood to have complex etiopathogenesis.

Is there a relation between vitamin D, interleukin-17, and bone mineral density in patients with inflammatory bowel disease?

“…In the study by Sahin et al no difference was noted in the IL-17 concentration between patients with CD and healthy people. Furthermore, no difference was noted between the patients with active CD and patients with inactive CD [45]. Schwarzmaier et al, in a study assessing the peripheral functions of monocytes, found that the expression and IL-17 release, as compared to other proinflammatory expression and cytokines released, did not differ between non-active CD patients and healthy people from the control group [46].…”

“…Further studies are needed with serial IL-17 measurements for evaluation of serum IL-17 as a disease-monitoring marker. Moreover, studies should be conducted on larger groups to evaluate serum IL-17 levels in patients with severely active IBD as compared to those in healthy subjects [45].…”

Expression and significance of interleukin-17 and interleukin-22 in the serum and the lower esophageal sphincter of patients with achalasia

“…[ 23 24 ] It has also been shown that the expression of inflammatory mediators such as Th17 and IL-17 is significantly increased in the histopathological tissue sections obtained from patients with Crohn's disease and that these inflammatory biomarkers are associated with the activity of Crohn's disease. [ 25 26 27 ] Similarly, Kristensen et al . [ 7 ] observed an increased expression of IL-17 in patients with autoimmune thyroid disease.…”

Lactobacillus acidophilus Improves Intestinal Inflammation in an Acute Colitis Mouse Model by Regulation of Th17 and Treg Cell Balance and Fibrosis Development

“…9,10 For instance, IL-17 expression, the number of Th17 cells, and serum IL-17 levels were increased in UV and CD patients. [11][12][13] IL-17A-deficient and IL-17 receptor-knockout mice were protected against colonic inflammation in dextran sodium sulfate (DSS)-induced colitis and trinitrobenzenesulfonic acid-induced colitis models, respectively. 14,15 Forkhead box P3 (Foxp3)-expressing T regulatory (Treg) cells play a critical role in maintaining immune homeostasis and controlling excessive inflammatory responses in the innate and adaptive immune systems.…”