Serum Interleukin-2 and Neopterin Levels as Useful Markers for Treatment of Active Pulmonary Tuberculosis

Turgut, Teyfik; Akbulut, Handan; Deveci, Figen; Kaçar, Canan; Muz, Mehmet Hamdi

doi:10.1620/tjem.209.321

Cited by 39 publications

(26 citation statements)

References 22 publications

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“…We identified significantly lower serum levels of RANTES in SARC patients, which contrasts a recent publication (23) that reports the opposite. Increased abundance of IFNγ in TB patients and almost undetectable levels of IL-2 were in agreement with previous findings (24), although increased levels of IL-2 in active TB have also been reported (25).…”

Section: Discussionsupporting

confidence: 93%

Common patterns and disease-related signatures in tuberculosis and sarcoidosis

Maertzdorf

Weiner

Mollenkopf

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

302

308

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In light of the marked global health impact of tuberculosis (TB), strong focus has been on identifying biosignatures. Gene expression profiles in blood cells identified so far are indicative of a persistent activation of the immune system and chronic inflammatory pathology in active TB. Definition of a biosignature with unique specificity for TB demands that identified profiles can differentiate diseases with similar pathology, like sarcoidosis (SARC). Here, we present a detailed comparison between pulmonary TB and SARC, including whole-blood gene expression profiling, microRNA expression, and multiplex serum analytes. Our analysis reveals that previously disclosed gene expression signatures in TB show highly similar patterns in SARC, with a common up-regulation of proinflammatory pathways and IFN signaling and close similarity to TB-related signatures. microRNA expression also presented a highly similar pattern in both diseases, whereas cytokines in the serum of TB patients revealed a slightly elevated proinflammatory pattern compared with SARC and controls. Our results indicate several differences in expression between the two diseases, with increased metabolic activity and significantly higher antimicrobial defense responses in TB. However, matrix metallopeptidase 14 was identified as the most distinctive marker of SARC. Described communalities as well as unique signatures in blood profiles of two distinct inflammatory pulmonary diseases not only have considerable implications for the design of TB biosignatures and future diagnosis, but they also provide insights into biological processes underlying chronic inflammatory disease entities of different etiology.G ene expression in peripheral blood cells from tuberculosis (TB) patients and healthy controls, both latently Mycobacterium tuberculosis-infected and uninfected, has been profiled by several groups in the recent past (1-7). Identified expression profiles indicate chronic activation of the immune system, with a marked activation of IFN signaling (3), proinflammatory signaling through the JAK-STAT pathway (5, 6), and elevated expression of Fc γ-receptors and their downstream response elements (2, 4). Although these biosignatures have been identified by several independent groups and possess the potential to discriminate latently M. tuberculosis-infected healthy individuals from active TB patients, the question remains whether these gene expression signatures are specific for TB or shared, at least in part, with diseases of similar pathology but distinct etiology.To address this question, we have conducted a comparative analysis of blood profiles in patients with active pulmonary disease manifestation of TB and sarcoidosis (SARC). The rational for choosing pulmonary SARC for such a comparison is the remarkable similarity in immune activation with active TB, suggesting a shared underlying pathophysiology (8). Although SARC is generally considered a noncommunicable disease of unknown etiology, patients with pulmonary involvement present with histological and ...

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Section: Discussionsupporting

confidence: 93%

Common patterns and disease-related signatures in tuberculosis and sarcoidosis

Maertzdorf

Weiner

Mollenkopf

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

302

308

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“…It is an indicator of pro-inflammatory immune status and a marker of cellular activation that is released into the circulation (6). Several researchers have reported higher levels of neopterin in many diseases including tuberculosis and cancer (6,7). But these studies were carried out outside Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Levels of Oxidative Metabolites, Antioxidants and Neopterin in Nigerian Pulmonary Tuberculosis Patients

2011

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“…In fact the decrease of anti-TBGL antibody after therapy has already been reported (Maekura et al 2001), but the effect of active TB treatment on IFN-γ responses has shown declining responses in some studies, whereas others have shown unchanging, fluctuating or increasing responses during treatment (Pai et al 2004;Dheda et al 2005). This variation was also observed in case of other cytokines (Turgut et al 2006;Djoba et al 2009). …”

Section: Discussionmentioning

confidence: 91%