2004
DOI: 10.1007/s00383-004-1329-x
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Serum interleukin-8 in children with biliary atresia: relationship with disease stage and biochemical parameters

Abstract: Biliary atresia (BA) is a neonatal obliterative cholangiopathy of unknown etiology. Despite the Kasai procedure, hepatic fibrosis and portal hypertension (PH) still occur. Interleukin-8 (IL-8) is an important mediator of inflammation and immune response in human disease. The objective of this study was to investigate the potential role of IL-8 in the pathogenesis of the progressive, sclerosing, inflammatory process and fibrosis in BA. A total of 60 pediatric patients with BA and 15 healthy children were evalua… Show more

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Cited by 33 publications
(32 citation statements)
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“…There have been few reports where soluble cytokines have been measured in BA. [11][12][13][14] These have been limited either to a single cytokine 11,12 or have looked only at a cross-section of an older BA population. 11,13,14,15 We therefore measured a representative panel of circulating mediators as markers of activity of the respective parent immune-competent cells (ICCs) and examined the evolution of this circulating immune / inflammatory response from diagnosis to, in some cases, endstage disease and transplantation.…”
Section: Discussionmentioning
confidence: 99%
“…There have been few reports where soluble cytokines have been measured in BA. [11][12][13][14] These have been limited either to a single cytokine 11,12 or have looked only at a cross-section of an older BA population. 11,13,14,15 We therefore measured a representative panel of circulating mediators as markers of activity of the respective parent immune-competent cells (ICCs) and examined the evolution of this circulating immune / inflammatory response from diagnosis to, in some cases, endstage disease and transplantation.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, increased production of IL-8 and IL-10 has been reported in patients with biliary obstruction and jaundice (10,11). Moreover, the cholestatic effect of cytokines (e.g.…”
mentioning
confidence: 99%
“…3,4 Thus, it is recommended that the patients included in the study be divided into different groups according to the degree of fibrosis (e.g., aspartate aminotransferase-to-platelet ratio index) and age (e.g., 60, 61-90, and > 90days).…”
Section: Hepatic Expression Of Interleukin 8 In Diagnosing Biliary Atmentioning
confidence: 99%