Serum iron as an indicator of acute inflammation in cattle

Abstract

The aim of this study was to assess the value of serum iron concentration in the diagnosis of acute inflammation in cattle. The diagnostic value of this approach was compared with that of various other hematological tests, including commonly used techniques that measure the levels of various other acute-phase proteins. The study population comprised 10 cows with acute traumatic reticuloperitonitis (RPT group) and 10 cows with acute mastitis (mastitis group) admitted to the Veterinary Teaching Hospital at Firat University (Elaziğ, Turkey). Ten cows from local barns, kept and fed under same conditions as the diseased animals, were used as controls. After the clinical examination, blood samples were collected for biochemical, hematological, and acute-phase protein (haptoglobin, serum amyloid A, α-1 acid glycoprotein, and fibrinogen) analyses. The mean levels of serum iron in the RPT, mastitis, and control groups were 6.00, 7.82, and 26.78 µmol/L, respectively. Serum iron level was significantly reduced in the RPT and mastitis groups. The results of this study indicate that serum iron analysis, preferably in combination with other markers of inflammation, may be a useful diagnostic tool for acute inflammation in cattle. Because serum iron measurement is individually available and easily applicable, it may be used for clinical cases as well as the determination of herd health.

Assessment of plasma nitric oxide concentration and erythrocyte arginase activity in dairy cows with traumatic reticuloperitonitis

“…It was reported that Fe deficiencies were triggered by cytokines in the time of the inflammatory response. It is stated that Fe concentrations decrease during the acute phase response (APR) in the organism due to inflammation in horses (Borges et al, 2007), dogs (Torrente et al, 2015), adult cattle (Baydar and Dabak 2014) and calves (Aydogdu et al, 2018). Baydar and Dabak (2014) stated that serum Fe concentration in cattle with mastitis and TRP is significantly decreased compared to the control group and serum Fe concentration may be a useful parameter for the determination of inflammation.…”

“…It is stated that Fe concentrations decrease during the acute phase response (APR) in the organism due to inflammation in horses (Borges et al, 2007), dogs (Torrente et al, 2015), adult cattle (Baydar and Dabak 2014) and calves (Aydogdu et al, 2018). Baydar and Dabak (2014) stated that serum Fe concentration in cattle with mastitis and TRP is significantly decreased compared to the control group and serum Fe concentration may be a useful parameter for the determination of inflammation. Borges et al (2007) reported that the decrease in serum Fe concentration in horses is a sensitive marker of acute, subacute and chronic systemic inflammation, and the change in Fe concentration may be a useful parameter for monitoring response to treatment.…”

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

“…It is reported that in humans with sepsis and SIRS, Fe concentrations are decreased and the monitoring of Fe concentrations may be beneficial (Shanbhogue and Paterson, 1990;Ayoglu et al, 2016). It is reported that in horses (Borges et al, 2007), dogs (Torrente et al, 2015), adult cattle (Baydar and Dabak, 2014) and calves (Aydogdu et al, 2018), Fe concentrations are decreased during acute phase response due to inflammatory reaction. It has been reported that in cattle with traumatic reticuloperitonitis (TRP) and mastitis, serum Fe concentrations are decreased compared to the control group and serum Fe concentrations in those diseases may be a useful parameter in the determination of inflammation (Baydar and Dabak, 2014).…”

“…It is reported that in horses (Borges et al, 2007), dogs (Torrente et al, 2015), adult cattle (Baydar and Dabak, 2014) and calves (Aydogdu et al, 2018), Fe concentrations are decreased during acute phase response due to inflammatory reaction. It has been reported that in cattle with traumatic reticuloperitonitis (TRP) and mastitis, serum Fe concentrations are decreased compared to the control group and serum Fe concentrations in those diseases may be a useful parameter in the determination of inflammation (Baydar and Dabak, 2014). In addition, it has been reported that decrease in the serum Fe concentrations in horses is a sensible marker for acute, subacute, and chronic systemic inflammation, and alteration in serum Fe concentration may be a useful parameter in monitoring the response to treatment (Borges et al, 2007).…”

Neuer Blick auf ein altes Element – Eisen, Hepcidin und Entzündung

“…Die ebenso analysierte Hepcidinkonzentration war vor der Behandlung mit durchschnittlich 58,4 ng/ml höher als nach der Behandlung (46,8 ng/ml) [42]. Ein Vergleich von Kühen mit Reticuloperitonitis oder Mastitis gegenüber gesunden Kontrolltieren ergab mittlere Serum-Fe-Konzentrationen von 6,0 µmol/l (Reticuloperitonitis), 7,8 µmol/l (Mastitis) und 26,8 µmol/l (Kontrollgruppe), woraus die Autoren eine Bedeutung von Fe als Entzündungsmarker für Einzeltiere und Herden ableiten [43]. Kürzlich wurde auch bei Entzündungen im Rahmen einer Enthornung ein signifikanter Abfall der mittleren Serum-Fe-Konzentration von 25,7 auf 16,1 µmol/l beschrieben [44].…”