Serum leptin levels are associated with cognitive function in older adults

Gunstad, John; Spitznagel, Mary Beth; Keary, Therese A.; Glickman, Ellen L.; Alexander, Thomas S.; Karrer, J; Stanek, Kelly M.; Reese, Lynn A.; Juvancic-Heltzel, Judi

doi:10.1016/j.brainres.2008.07.045

Cited by 61 publications

(41 citation statements)

References 22 publications

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“…In addition, both obesity and cognitive performance are correlated with dopamine pathway dysregulation, which may negatively affect cognition in older individuals [41,42] . Finally, obesity is associated with alterations in levels of brain-derived neurotrophic factor and leptin -biomarkers that have recently been linked to cognitive function in human studies [43,44] . Each of these mechanisms, in isolation or combination, may contribute to the observed cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

Gunstad

Lhotsky²,

Wendell³

et al. 2010

Neuroepidemiology

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Background: Obesity indices (i.e. BMI, waist-to-hip ratio) show differential relationships to other health outcomes, though their association to neurocognitive outcome is unclear. Methods: We examined whether central obesity would be more closely associated with cognitive function in 1,703 participants from the Baltimore Longitudinal Study of Aging. Results: Longitudinal mixed-effects regression models showed multiple obesity indices were associated with poorer performance in a variety of cognitive domains, including global screening measures, memory, and verbal fluency tasks. Obesity was associated with better performance on tests of attention and visuospatial ability. An obesity index by age interaction emerged in multiple domains, including memory and attention/executive function. Conclusion: Obesity indices showed similar associations to cognitive function, and further work is needed to clarify the physiological mechanisms that link obesity to poor neurocognitive outcome.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

Gunstad

Lhotsky²,

Wendell³

et al. 2010

Neuroepidemiology

Self Cite

319

244

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“…High levels of leptin, an adipokine hormone typically linked to eating behavior through its action in the hypothalamus and striatal regions, are associated with smaller volumes of some frontal structures [30]. Consistent with these structural findings, elevated leptin levels are associated with reduced cognitive task performance, specifically frontal systems cognitive function [26]. Finally, the orexigenic hormone, ghrelin, is associated with increased disinhibition [31] and negatively correlated with several cognitive domains, including verbal memory, working memory, and naming [25].…”

Section: Introductionmentioning

confidence: 64%

“…However, these biomarkers not only appear to be related to eating and weight, but are also linked with cognition. Specifically, there is evidence that increased ghrelin [25] and leptin [26] and decreased BDNF [27] are associated with poorer cognitive performance in healthy older adults. BDNF, a protein important for neuronal development, maintenance, and function, is reduced in patients with AD and vascular dementia relative to healthy older adults [28,29].…”

Section: Introductionmentioning

confidence: 99%

“…BDNF, a protein important for neuronal development, maintenance, and function, is reduced in patients with AD and vascular dementia relative to healthy older adults [28,29]. In addition, higher serum BDNF is associated with better cognitive test performance in healthy older adults [26]. High levels of leptin, an adipokine hormone typically linked to eating behavior through its action in the hypothalamus and striatal regions, are associated with smaller volumes of some frontal structures [30].…”

Section: Introductionmentioning

confidence: 99%

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Impact of 6-Month Exercise Program on Weight Status and Associated Biomarkers in Mild Cognitive Impairment

et al. 2011

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Unintentional weight loss in Alzheimer's disease (AD) predicts morbidity and mortality, but effectiveness of dietary supplementation is reduced in those with low body mass index. Exercise may be beneficial, particularly if started early. Thirty-one participants with mild cognitive impairment (MCI) completed measures of cardiovascular fitness, eating behavior, cognitive function, and body composition before and following a 6-month exercise program. Ghrelin, leptin, and brain-derived neurotrophic factor were measured to elucidate the relationship between cognition and response to exercise. Significant baseline relationships emerged among appetite and both cardiovascular fitness and neurocognition. Following the exercise program, improvements in cardiovascular fitness and healthy eating habits occurred, body composition and biomarkers remained stable, and cognition declined. This study suggests exercise may benefit persons with MCI by promoting healthier eating habits and possibly stabilizing body composition and biomarkers. Although increased fitness did not stabilize cognitive decline in MCI, exercise may positively impact eating behavior.

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“…Finally, our results indicate a negative correlation between leptin and visuospatial/ executive and language functions. A study in older adults also showed a negative association between serum leptin levels and executive function, while the Edinburgh Type 2 Diabetes Study reported that higher leptin concentrations were associated with overall cognitive decline and poorer executive function performance only in men with T2D (39,40). Further research is needed in order to elucidate the implications of leptin in various cognitive functions in subjects with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Markers of cognitive impairment in patients with type 2 diabetes

Șular¹,

Huţanu²,

Voidăzan³

2016

Revista Romana De Medicina De Laborator

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Background. The study aimed to evaluate the correlations of cognitive function with metabolic, nutritional, hormonal and immunologic parameters in patients with type 2 diabetes (T2D), in order to identify markers of cognitive impairment. Material and methods. This cross-sectional study included 216 T2D patients and 23 healthy individuals (HC p: 0.004). T2D patients with cognitive dysfunction were significantly older and less formally educated (p < 0.0001). Age negatively correlated with MoCA scores p < 0.0001). T2D patients had significantly lower p < 0.0001). Serum Mg levels positively correlated with MoCA scores (0.24, 95%CI: 0.07, 0.39; p: 0.003) and with visuospatial/executive (0.30; 95%CI: 0.14, 0.45; p: 0.0002) and naming functions (0.18; 95%CI: 0.01, 0.34; p: 0.02

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Serum leptin levels are associated with cognitive function in older adults

Cited by 61 publications

References 22 publications

Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

Impact of 6-Month Exercise Program on Weight Status and Associated Biomarkers in Mild Cognitive Impairment

Markers of cognitive impairment in patients with type 2 diabetes

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