Serum level of 25‐hydroxyvitamin D and obesity among early pregnant women

Mahmoud, Sally Z.; Saad, Alfarazdeg A.; Mohieldein, Abdelmarouf; Nasr, Abubakr M.; Adam, Ishag

doi:10.1111/jog.14114

Cited by 5 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results indicated a positive association between maternal serum 25(OH)D concentration and the number of parity. One study mentioned that there was no significant difference between serum 25(OH)D concentration and age, parity, or gestational age [ 35 ], and no association between parity and 25(OH)D concentration was observed in another study [ 36 ]. While Shen et al found that high parity was associated with increasing serum vitamin D status [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Luo

Yun-ya

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food supplements. Other metabolites (laboratory parameters) are also important in reflecting gestational states. This study aimed to investigate the association of serum 25(OH)D status in early pregnancy with GDM and other laboratory parameters in pregnant women. Methods A total of 1516 pregnant women whose blood glucose were normal before pregnancy in the city of Foshan in Guangdong, China were enrolled in this study. GDM was diagnosed between 24 to 28 weeks of pregnancy following the guidelines from the American Diabetes Association. Maternal serum 25(OH)D and other laboratory parameters—including hematology, coagulation, chemistry, and bone density—were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14. Results The average 25(OH)D concentration was 59.1 ± 12.6 nmol/L. None of the study subjects had 25(OH)D < 25 nmol/L; 434 (28.6%) women had 25(OH)D deficiency (< 50 nmol/L), 882 women (58.2%) had 25(OH)D insufficiency (50–74 mmol/L) and 200 women (13.2%) had 25(OH)D sufficiency (≥ 75 nmol/L). There were 264 (17.4%) women diagnosed with GDM. There was not, however, an association between serum 25(OH)D in early pregnancy and GDM. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum 25(OH)D levels. There was a possible positive association between serum 25(OH)D and pre-albumin, and a possible negative association between serum 25(OH)D, creatinine, and thrombin time. This study did not find an association between serum 25(OH)D and bone density. Conclusions There were no associations between maternal serum 25(OH)D concentration in early pregnancy and the risk of GDM or bone density. There were, however, correlations between serum 25(OH)D and parity, seasoning at sampling, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factor thrombin time, which need further study to explain their pathophysiology and clinical significance.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Luo

Yun-ya

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…In this study, we found that there was a positive correlation between maternal serum VD level and the number of parity; women who had given birth 3 times had higher serum VD than those giving birth 2 or 1 time (s) (p=0.016 and 0.039, respectively, Table 5a and 5b) . One study mentioned that there was no signi cant difference between the serum VD level and age, parity, or gestational age [25]. The mechanism underlying this phenomenon is therefore unclear; there could be certain compensation in metabolism function during pregnancy that requires further investigation in the future.…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Vitamin D Status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Luo

Yun-ya

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Pregnant women develop certain metabolic alterations and substantial nutrient insufficiency, which may impact fetus development. Reports on the association of serum 25-hydroxy vitamin D (25(OH)D, VD) status with gestational diabetes mellitus (GDM) is still controversial. This study aimed to investigate the association of serum VD status with GDM and other laboratory parameters in early pregnant women.Methods: A total of 1516 pregnant women were enrolled in this study. Maternal serum VD and other laboratory parameters—including hematology, coagulation, chemistry, and bone density—were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14. Serum VD level was subsequently correlated with blood glucose and other laboratory parameters.Results: The average VD concentration was 59.12 ± 12.5 nmol/L. None of the study subjects had VD <25 nmol/L; 434 (28.6%) women had VD <50 nmol/L, and 200 women (13.2%) had VD ≥75 nmol/L. There were 264 (17.4%) women diagnosed with GDM. There was not, however, a correlation between serum VD and GDM in early pregnancy. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum VD levels. There was a positive correlation between serum VD and pre-albumin, activated partial thromboplastin time, and a negative correlation between serum VD, creatinine, and thrombin time.Conclusions: There was no correlation between maternal serum VD and GDM in early pregnant women. There were, however, associations between serum VD and parity, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factors, which need further study to explain their pathophysiology and clinical significance.

show abstract

“…The sample was (60 women in each arm) calculated as the ratio of 1:1 between the cases and the controls. Depending on our previous reports on the serum concentration of 25(OH)D (15.0 ng/mL) among pregnant Sudanese women [23], we assumed that women with PB would have a concentration of 25(OH)D of 10.0 ng/mL. Based on our recent reports on the level of 25(OH)D among women with preeclampsia [24], we assumed a mean difference of 5 ng/mL in the serum 25(OH)D concentration between the women who had PB and the healthy controls.…”

Section: Sample Size Calculationmentioning

confidence: 99%

“…There are no published data on the association between serum 25(OH)D concentrations/vitamin D deficiency and risk of PB in Sudan. We recently reported that the majority (94%) of pregnant Sudanese women have vitamin D deficiency (≤20 ng/mL) [23]. Thus, it is vital to determine if vitamin D levels are associated with PB in Sudan.…”

Section: Introductionmentioning

confidence: 99%

Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

There are few published studies on the association between vitamin D concentrations and preterm birth (PB) in sub-Saharan Africa. The current study aimed to assess the association between 25-hydroxyvitamin D (25[OH)] D) levels and PB. A matched case–control study (60 women in each arm) was conducted in Medani maternity hospital in central Sudan. The cases were women with spontaneous PB, and healthy women with term deliveries were the controls. The clinical/medical and obstetric history was gathered using a questionnaire. The enzyme-linked immunosorbent assay was used to measure the serum 25(OH)D levels. Women with PB had significantly lower median (interquartile range) 25(OH)D concentrations compared with the controls (18.4 (7.3) ng/mL vs. 20.2 (16.5) ng/mL, p = 0.001). Forty-two (70.0%) women with PB and 29 (48.3%) women in the control group had vitamin D deficiency (25(OH)D level ≤ 20 ng/mL). The results of the multivariable logistic regression showed that the 25(OH)D concentrations were negatively associated with PB (adjusted odds ratio (aOR) = 0.92, 95% confidence interval (CI) = 0.87–0.97). Vitamin D-deficient pregnant women were at a higher risk of PB (aOR = 2.69, 95% CI = 1.17–6.23). Low 25(OH)D concentrations were found at the time the variable was determined in women with spontaneous PB and were an independent risk factor for PB.

show abstract

Serum level of 25‐hydroxyvitamin D and obesity among early pregnant women

Cited by 5 publications

References 37 publications

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Association of Serum Vitamin D Status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study

Contact Info

Product

Resources

About