Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch–Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression

Liu, Qiang; Yang, Yun Seok; Ge, Shealinna; Huo, JianLi; Wang, Dahu; Ma, Yaohui; Ding, Luo; Deng, Jiehua; Ren, Cuimin; Guo, BingShen

doi:10.1111/ijd.14550

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…Our results are consistent with the study conducted by Descamps-Latscha et al [44] on 59 CKD patients, where a positive correlation between serum AOPP and CRPus levels was reported (r = 0.255, p < 0.05). Furthermore, AOPP could be involved in the pathogenesis of the micro-inflammation of chronic kidney disease by inducing increased expression of fibronectin and collagen I in mesangial cells and enhance vascular inflammation by stimulating pro-inflammatory mediators such as vascular-1 and intercellular-1 cell adhesion molecules [45,46]. Therefore, the increase of AOPP and CRPus could reflect the progression of CKD stage and the degradation of renal function.…”

Section: Discussionmentioning

confidence: 99%

Implications of advanced oxidation protein products and vitamin E in atherosclerosis progression

toualbi¹,

Adnane

Ballouti

et al. 2021

Arch Med Sci Atheroscler Dis

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Introduction: Advanced oxidation protein products (AOPP) are considered as markers of oxidative stress and inflammation, and highly predictive of atherosclerosis. Vitamin E (Vit-E) is a powerful antioxidant, but no consensus on its effectiveness at the level of AOPP or the process of atherosclerosis has been made. Hence this was the aim of the present study. Material and methods: A longitudinal study was conducted on 205 patients with chronic kidney disease (CKD) and 40 controls. The correlations between AOPP and glomerular filtration rate (GFR) and different biological markers were analyzed. Supra-aortic trunk echo-Doppler was conducted to assess the correlation of AOPP with intima-media thickness. The effects of Vit-E treatment on AOPP levels and atherosclerosis progression were also investigated. Results: AOPP levels increased in parallel to the alteration of renal functions in CKD patients, compared to the control group (p < 0.05). The mean value of AOPP increased concomitantly with the intima-media thickness (p < 0.05). Furthermore, AOPP mean value was higher in patients with atherosclerotic plaques (p < 0.05) compared to those without plaques. Vit-E treatment stabilized the levels of AOPP but had no effect on the atherosclerotic progression. Conclusions: AOPP were proved to be effective markers of oxidative stress and their high levels help to predict the progression of atherosclerosis. As a powerful antioxidant, Vit-E stabilized the AOPP levels.

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Section: Discussionmentioning

confidence: 99%

Implications of advanced oxidation protein products and vitamin E in atherosclerosis progression

toualbi¹,

Adnane

Ballouti

et al. 2021

Arch Med Sci Atheroscler Dis

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“…In an in vivo study, white N. nucifera petal extract was shown to reduce LPO of PUFAs in Charolais cattle sperm exposed to mancozeb at low doses of 0.22 and 0.44 µg/mL [12]. Moreover, on the external surface of cell membranes, most of the proteins and some of the lipids are conjugated with short chains of carbohydrates [63]. The most common results of glycoxidation are increased advanced oxidation protein products (AOPPs) and advanced glycation end products (AGEs) [66].…”

Section: Effect Of White N Nucifera Gaertn Petal Tea Extract On Oxida...mentioning

confidence: 99%

“…Cell and organelle membranes are made from a double layer of a polar hydrophilic head and a non-polar hydrophobic tail. In most mammalian cell membranes, there are both straight-chained saturated fatty acids and unsaturated fatty acids [63]. Their polyunsaturated fatty acids (PUFAs) are sensitive to oxidative stress, which is known as lipid peroxidation (LPO) [64].…”

Section: Effect Of White N Nucifera Gaertn Petal Tea Extract On Oxida...mentioning

confidence: 99%

“…Moreover, on the external surface of cell membranes, most of the proteins and some of the lipids are conjugated with short chains of carbohydrates [63]. The most common results of glycoxidation are increased advanced oxidation protein products (AOPPs) and advanced glycation end products (AGEs) [66].…”

Section: Effect Of White N Nucifera Gaertn Petal Tea Extract On Oxida...mentioning

confidence: 99%

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Neuroprotective Effect of White Nelumbo nucifera Gaertn. Petal Tea in Rats Poisoned with Mancozeb

Intui,

Nuchniyom,

Laoung-on

et al. 2023

Foods

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Nelumbo nucifera Gaertn. (N. nucifera) tea is used as food and folk medicine to reduce toxicity in Southeast Asia. Mancozeb (Mz) is used for controlling fungi in agriculture and contains heavy metals. This study aimed to examine the effect of white N. nucifera petal tea on cognitive behavior, hippocampus histology, oxidative stress, and amino acid metabolism in rats poisoned with mancozeb. Seventy-two male Wistar rats were divided into nine groups (n = 8 in each). Y-maze spontaneous alternation test was used to assess cognitive behavior, and amino acid metabolism was investigated by nuclear magnetic resonance spectroscopy (1H-NMR) from blood. There was a significant increase in relative brain weight in the Mz co-administered with the highest dose (2.20 mg/kg bw) of white N. nucifera group. The levels of tryptophan, kynurenine, picolinic acid, and serotonin in blood showed a significant decrease in the Mz group and a significant increase in the Mz co-administered with low dose (0.55 mg/kg bw) of white N. nucifera group. However, there was no significant difference in cognitive behavior, hippocampus histology, oxidative stress, and corticosterone. This study demonstrated that a low dose of white N. nucifera petal tea has a neuroprotective effect against mancozeb.

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“…These processes have been associated with the development of autoimmune and inflammatory diseases (14). Several studies have shown that NETs are involved in the development and progression of autoimmune diseases such as ANCA-associated vasculitis, rheumatoid arthritis (RA), inflammatory bowel disease and systemic lupus erythematosus (SLE) (15)(16)(17)(18). A recent study reported that MPO-DNA is significantly elevated in the circulation of patients with IgAV and positively correlates with IgA levels, which suggests that NETs are involved in the pathogenesis of IgAV (19).…”

Section: Nets Involved In the Pathogenesis Of Igavmentioning

confidence: 99%

An Emerging Role for Neutrophil Extracellular Traps in IgA Vasculitis: A Mini-Review

Chen

Tu²,

Tang³

et al. 2022

Front. Immunol.

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Immunoglobulin A vasculitis (IgAV) is the most common systemic small vessel vasculitis in childhood. Its clinical manifestations are non-thrombocytopenic purpura, accompanied by gastrointestinal tract, joint, kidney and other organ system involvement. The pathogenesis of IgAV has not been fully elucidated. It may be related to many factors including genetics, infection, environmental factors, and drugs. The most commonly accepted view is that galactose-deficient IgA1 and the deposition of IgA and complement C3 in small blood vessel walls are key contributors to the IgAV pathogenesis. Extensive neutrophil extracellular traps (NETs) in the peripheral circulation and skin, kidney, and gastrointestinal tissue of patients with IgAV has been identified in the past two years and is associated with disease activity. This mini-review provides a possible mechanism for NETs involvement in the pathogenesis of IgAV.

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Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch–Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression

Cited by 4 publications

References 12 publications

Implications of advanced oxidation protein products and vitamin E in atherosclerosis progression

Implications of advanced oxidation protein products and vitamin E in atherosclerosis progression

Neuroprotective Effect of White Nelumbo nucifera Gaertn. Petal Tea in Rats Poisoned with Mancozeb

An Emerging Role for Neutrophil Extracellular Traps in IgA Vasculitis: A Mini-Review

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