Serum Level of Macrophage Migration Inhibitory Factor (MIF) in Egyptians With Alopecia Areata and Its Relation to the Clinical Severity of the Disease

Younan, Doreen N.; Agamia, Naglaa; El-Shafei, A.E; Ebeid, Nancy

doi:10.1002/jcla.21731

Cited by 12 publications

(11 citation statements)

References 28 publications

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“…MIF was originally identified because of its ability to inhibit the random migration of macrophages in vitro. MIF is expressed in hair follicles, and there is a close association between reduced MIF in hair follicles and the development of alopecia areata, which is an autoimmune disease of the skin [ 59 , 60 ]. Interestingly, treatment with TGF-β1 and LiCl induced the expression of MIF in MSCs, and treatment with MIF induced DPC viability for recruitment of the conduction ability.…”

Section: Discussionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related β-catenin and p-GSK-3β [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia.

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Section: Discussionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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“…There is still controversy over attribution of an anti‐inflammatory role to MIF. Although histological studies have shown significant downregulation of MIF in AA lesions, and several studies from other IP sites also agree on its inhibitory functions, recent findings have implicated a proinflammatory role for MIF …”

Section: How Do Immune Privilege Sites Prevent Natural Killer Cell Acmentioning

confidence: 95%

“…Although histological studies have shown significant downregulation of MIF in AA lesions, and several studies from other IP sites also agree on its inhibitory functions, 50-53 recent findings have implicated a proinflammatory role for MIF. 29,[54][55][56][57][58][59][60][61][62][63] Another less emphasized mechanism for preventing NK cells from attacking the MHC-negative cells is the expression of nonclassical MHC-I proteins such as human leucocyte antigen (HLA)-G and HLA-E. These MHCs play a great role in preserving fetomaternal tolerance and ocular IP, but their contribution to HF privilege remains to be elucidated.…”

Section: How Do Immune Privilege Sites Prevent Natural Killer Cell Acmentioning

confidence: 99%

Alopecia areata: a review of disease pathogenesis

et al. 2018

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“…So, it is considered to be a promising target in the therapy of autoimmune diseases and as a future predictor of alopecia activity. Anti-MIF therapy might be added as one of the new biological treatments for AA [38].…”

Section: Recent Concepts In the Pathogenesis Of Alopecia Areatamentioning

confidence: 99%

Etiopathogenesis of Alopecia Areata

Bhat¹,

Sajad²,

Hassan³

2014

Hair Therap Transplantat

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Alopecia areata (AA) is a recurrent, non-scarring type of hair loss affecting the hair follicles and sometimes the nails. Current evidence indicates that hair follicle inflammation in alopecia areata is caused by a T-cell mediated autoimmune mechanism occurring in genetically predisposed individuals. Environmental factors like infections, diet, vaccination and stress may be responsible for triggering the disease. The association between alopecia areata and other autoimmune diseases suggests that alopecia areata is itself an autoimmune disease. Recently many cytokines have been implicated in the pathogenesis of AA and these are focused upon in this article.

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Serum Level of Macrophage Migration Inhibitory Factor (MIF) in Egyptians With Alopecia Areata and Its Relation to the Clinical Severity of the Disease

Abstract: MIF seems to have an essential role in the etiopathogenesis of AA. So, it is considered to be a promising target in the therapy of autoimmune diseases and as a future predictor of alopecia activity. Anti-MIF therapy might be added as one of the new biological treatments for AA.

Cited by 12 publications

References 28 publications

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Alopecia areata: a review of disease pathogenesis

Etiopathogenesis of Alopecia Areata

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