Serum level of prostate-specific antigen (PSA) in women with breast cancer

Mashkoor, Fawzi C; Al-Asadi, Jasim N.; Al-Naama, Lamia M.

doi:10.1016/j.canep.2013.06.009

Cited by 31 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elimination of periodontal pathogens through periodontal therapy may reduce exposure of the prostate to invasion by bacteria and their toxins. Another hypothesis is that the periodontium may be a distant non-prostatic source of PSA, such as that reported in cases of breast cancer in females, where PSA level is reduced after oncologic treatment [26]. In the present study, significant improvement was also noticed in IPSS, 4 to 8 weeks after periodontal treatment.…”

Section: Discussionsupporting

confidence: 79%

Periodontal Treatment Improves Prostate Symptoms and Lowers Serum PSA in Men with High PSA and Chronic Periodontitis

Alwithanani¹,

Bissada

Joshi³

et al. 2015

Dentistry

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 79%

Periodontal Treatment Improves Prostate Symptoms and Lowers Serum PSA in Men with High PSA and Chronic Periodontitis

Alwithanani¹,

Bissada

Joshi³

et al. 2015

Dentistry

View full text Add to dashboard Cite

show abstract

“…They also registered a significant difference in the pre and post-surgery level of free PSA in their study on 30 breast cancer patients suggesting that free PSA can be used as both a diagnostic as well as prognostic marker in breast cancer. Mashkoor et al [63] also documented a significant fall in the level of TPSA and FPSA after surgical removal of tumour mass in their study on 55 breast cancer patients and 82 controls. They registered a high TPSA and FPSA level in breast cancer patients which was positively correlated with younger age group and early stage of cancer.…”

Section: Psa In Femalesmentioning

confidence: 81%

Reconnoitring the Status of Prostate Specific Antigen and its Role in Women

Dash

2014

Ind J Clin Biochem

View full text Add to dashboard Cite

“…Recently, it has been shown that elevated levels of prostate-specific antigen are also observed in some breast and gynecologic cancers. 28,29 In addition, overexpression of the EGFR gene occurs across a wide range of different cancers, including brain, colorectal, lung, esophageal, cervical cancers, and sarcoma. [30][31][32][33][34][35] CDH1 and VEGFA have been reported among the highly significant markers in colorectal, gastric, and liver cancers.…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin

Xu¹,

Chen²,

et al. 2016

Modern Pathology

View full text Add to dashboard Cite

Carcinoma of unknown primary, wherein metastatic disease is present without an identifiable primary site, accounts for~3-5% of all cancer diagnoses. Despite the development of multiple diagnostic workups, the success rate of primary site identification remains low. Determining the origin of tumor tissue is, thus, an important clinical application of molecular diagnostics. Previous studies have paved the way for gene expression-based tumor type classification. In this study, we have established a comprehensive database integrating microarray-and sequencing-based gene expression profiles of 16 674 tumor samples covering 22 common human tumor types. From this pan-cancer transcriptome database, we identified a 154-gene expression signature that discriminated the origin of tumor tissue with an overall leave-one-out cross-validation accuracy of 96.5%. The 154-gene expression signature was first validated on an independent test set consisting of 9626 primary tumors, of which 97.1% of cases were correctly classified. Furthermore, we tested the signature on a spectrum of diagnostically challenging tumors. An overall accuracy of 92% was achieved on the 1248 tumor specimens that were poorly differentiated, undifferentiated or from metastatic tumors. Thus, we have identified a 154-gene expression signature that can accurately classify a broad spectrum of tumor types. This gene panel may hold a promise to be a useful additional tool for the determination of the tumor origin.

show abstract

Serum level of prostate-specific antigen (PSA) in women with breast cancer

Cited by 31 publications

References 30 publications

Periodontal Treatment Improves Prostate Symptoms and Lowers Serum PSA in Men with High PSA and Chronic Periodontitis

Periodontal Treatment Improves Prostate Symptoms and Lowers Serum PSA in Men with High PSA and Chronic Periodontitis

Reconnoitring the Status of Prostate Specific Antigen and its Role in Women

Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin

Contact Info

Product

Resources

About