Serum level of some micronutrients in children infected with Helicobacter pylori

Abstract

Background: Helicobacter pylori (H. pylori) proved to be highly prevalent all over the world. H. pylori may modify the absorption of many nutrients. Studies have suggested that, beyond iron, H. pylori infection may affect the homeostasis of other micronutrients such as vitamins and trace elements. Our study's aim was to assess the effect of H. pylori infection on some blood micronutrient level including zinc, selenium, vitamin C, and vitamin B 12 in children with chronic or recurrent unexplained dyspeptic symptoms and/or non-variceal hematemesis. Results: A cross-sectional case-control study was carried out in 32 children (4-18 years) with chronic or recurrent unexplained dyspeptic symptoms and/or non-variceal hematemesis. Patients were divided according to the results histopathology and rapid urease test into two groups, H. pylori-positive patients (18 patients) and H. pylori-negative patients (14 patients). Another control group of 18 children was included. Serum levels of zinc, selenium, vitamin C, and vitamin B 12 were measured in all children. Prevalence of H. pylori infection was 56.2%. The mean serum zinc levels were significantly lower in H. pylori-positive cases than in control group (84.2 ± 13.85 versus 94.6 ± 6.52 with P = 0.009) and lower than in H. pylori-negative cases but not statistically significant (84.2 ± 13.85 versus 92.2 ± 8.53 with P = 0.054). The mean serum vitamin C levels were significantly lower in H. pylori-positive cases than in negative cases and control group (220.7 ± 46.16 versus 305.1 ± 28.83 and 313.1 ± 31.43 with P < 0.0001). The mean serum vitamin B 12 levels were significantly lower in H. pylori-positive cases than in negative cases and control group (167.8 ± 76.98 versus 290.1 ± 69.92 and 326.1 ± 38.67 with P < 0.0001). The mean serum selenium level was slightly higher in H. pylori-positive patients than in H. pylori-negative patients and control group but not statistically significant (118.2 ± 11.13 versus 112.1 ± 8.69 and 113.1 ± 13.76 with P = 0.096, 0.243 respectively). Conclusion: Helicobacter pylori infection in children has a significant negative effect on the serum levels of zinc, vitamin C, and vitamin B 12 .

Effect of Helicobacter pylori Infection on Macromineral and Trace Element Status—Systematic Review and Meta‐Analysis

“…Three cross-sectional studies (19,21,22) compared zinc levels in Hp -positive and Hp -negative children. A total of 477 patients were included (45.7% male, with an overall age range of 4–18 years), of whom 29.5% were Hp -positive.…”

“…Risk of bias assessment of each included study is available in Supplemental Digital Content 7, http://links.lww.com/ MPG/C876 and paired with the respective forest plot. In overall appraisal, 5 studies (18)(19)(20)(21)(22) had a risk of bias, whereas 1 study (23) had a moderate risk of bias.…”

“…Only one study (21) described dietary assessment. Hp infection was diagnosed by RUT and histopathological examination in 2 studies (19,22) and by 13 C-UBT in 1 study (21). The outcome assessed was serum zinc levels in all studies, measured by spectrophotometry (19,21) or colorimetric assay (CA) (22).…”

A Covid-19 E Seus Efeitos No Comportamento Alimentar Dos Moradores Da Cidade De São José Dos Campos

“…Com referência a deficiência do zinco pressupõe-se que há uma ruptura da integridade do trato gastrointestinal, logo, pode reduzir a absorção normal de zinco da dieta e comprometer a circulação enteropancreática de zinco. Ademais, quando o pH gástrico se eleva como consequência da infecção, os hidratos perdem prótons e formam hidróxidos menos solúveis ou insolúveis, os quais podem influenciar na absorção de zinco (ELSAGHIER et al, 2020). Coincidindo com o documentado em outros estudos, sobre a prevalência da infecção por H. pylori (PARENTE et al, 2010;HOOI et al, 2017;COSTA et al, 2021), encontramos uma alta prevalência (51,4%) da infecção por H. pylori entre as crianças estudadas.…”

Alimentação E Saúde: Uma Análise Sobre O Consumo De Produtos Orgânicos Durante a Pandemia Da Covid-19

“…Os componentes dietéticos que tem impacto na inibição da absorção de Zn são fitato e cálcio, enquanto que os promotores da absorção são a qualidade e quantidade de proteína (IZINCG, 2009;COZZOLINO, 2016). Nesse contexto, estudos têm mostrado a contribuição da infecção pelo H. pylori e a deficiência de Zn (FRANCESCHI et al, 2014;ELSAGHIER et al, 2020).…”