Serum levels of copper, iron, and manganese in women with pregnancy, miscarriage, and primary infertility

Skalnaya, Margarita G.; Tinkov, Alexey A.; Lobanova, Yulia N.; Chang, Jinn-Ming; Skalny, Anatoly V.

doi:10.1016/j.jtemb.2019.08.009

Cited by 43 publications

(26 citation statements)

References 53 publications

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“…Serum Zn levels, on the other hand, showed no difference [21]. In contrast to our findings, Skalnaya et al (2019) discovered that the serum Cu level was high [22]. Alvarez et al (2007) discovered that serum Zn levels decreased during pregnancy while serum Cu levels increased in a study of 159 healthy pregnant women [23].…”

Section: Discussioncontrasting

confidence: 93%

Correlation of Abortus Imminence Cases in the First Trimester with Biochemical Markers

Kubat¹,

Dilara²,

Berkan³

et al. 2023

OJOG

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Objective: In this study, we compared the biochemical markers of imminent abortion, missed abortion, and healthy pregnant women in the first trimester to see if there were any differences. Materials and Methods: The study method is prospective. Pregnant women who applied to the obstetrics clinic of Istanbul Training and Research Hospital between 01.04.22 and 31.10.22 were diagnosed with abortion imminens or missed abortion between 6 weeks and 12 weeks or had normal pregnancy follow-up, had no chronic diseases, and did not take magnesium and calcium supplements were included in the study. 20 pregnant women with missed abortion, 20 pregnant women with abortion imminens diagnosis and 20 normal pregnant women who met the criteria were included in the study. Magnesium (Mg), calcium (Ca), copper (Cu), zinc (Zn) and hemogram (CBC) levels were checked in pregnant women included in the study. Results: The Mg, Cu, Zn, and CBC values of the study participants' women did not differ in a statistically significant way. When compared to pregnant women who had a normal pregnancy process, the difference in Ca value was found to be statistically substantially smaller in pregnant women who were diagnosed with abortion imminens and missed abortion. The findings of our study suggest that serum Ca levels be measured prior to conception or at the initial visit. Conclusion: Serum Ca levels were found to be significantly lower in the missed abortion group than in the abortus imminens and normal pregnant groups in our study (p < 0.05).

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Section: Discussioncontrasting

confidence: 93%

Correlation of Abortus Imminence Cases in the First Trimester with Biochemical Markers

Kubat¹,

Dilara²,

Berkan³

et al. 2023

OJOG

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“…The search also resulted in study findings involved in other single micronutrients. In a Russian study concerning serum metal concentration in the blood of women, it was found that females with infertility and miscarriage had a lower concentration of copper than pregnant women [55]. Moreover, there was no difference between the copper levels of pregnant women and a healthy control group, which supports the hypothesis that copper may play a role in female fertility.…”

Section: Antioxidantsmentioning

confidence: 78%

“…The studies were performed internationally and included the following countries USA (n = 20) [15,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45], Australia (n = 1) [46], New Zealand (n = 1) [46], Ireland (n = 1) [46], United Kingdom (n = 2) [46,47], China (n = 1) [48], Denmark (n = 4) [41,43,49,50], Greece (n = 1) [14], Iran (n = 2) [51,52], Brazil (n = 2) [53,54], Canada (n = 1) [43], Russia (n = 1) [55], Italy (n = 2) [56,57], Spain (n = 1) [58]. The articles concerned female fertility and the intake of a Mediterranean dietary pattern (n = 2) [51,57], fruit, vegetables and whole grain intake (n = 3) [38,46,53], fish (n = 1) [42], dairy (n = 3) [15,43,44], types of fatty acids (n = 4) [39]…”

Section: Resultsmentioning

confidence: 99%

“…The articles concerned female fertility and the intake of a Mediterranean dietary pattern (n = 2) [51,57], fruit, vegetables and whole grain intake (n = 3) [38,46,53], fish (n = 1) [42], dairy (n = 3) [15,43,44], types of fatty acids (n = 4) [39][40][41], soy (n = 2) [32,33], caffeine (n = 3) [45,50,54], folate and B12 (n = 4) [34,35,59,60], melatonin (n = 1) [58], CoQ10 (n = 1) [48] as well as a combination of different compounds (n = 4) [37,47,52,55]. The women who participated in the studies were either planning pregnancy (n = 6) [36,40,41,45,46,55], infertile (n = 3) [49,51,55], undergoing or subjected to assistive reproductive technology (ART) therapy (n = 16) [14,15,31,34,35,39,42,44,50,[52]…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Emerging Trends in Research on Food Compounds and Women’s Fertility: A Systematic Review

et al. 2020

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Pro-healthy behaviours, including the diet, are significant factors in maintaining women’s fertility health. However, to improve the patient’s nutrition management, it is important to seek food-derived bioactive compounds to support fertility treatment. This review analysed recent studies of food compounds related to fertility, using databases including PubMed, Web of Science and Science Direct as well as PRISMA (preferred reporting items for systematic reviews) to ensure complete and transparent reporting of systematic reviews. This review lists foods associated with a higher birth rate, using original papers from the last five years (2015). The analysis included the impact of food compounds such as caffeine, fatty acids, folates and vitamin D, as well as the intake of fish, whole grains, dairy and soya. In addition, dietary patterns and total diet composition supporting women’s fertility were also analysed. The results will encourage further research on the relationship between food components and fertility.

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“…There is very little information about rubidium (Rb) in the literature, especially about the concentration of this trace element in pregnant women [19]. Although Rb is recognized to be crucial for the embryonic development [20,21], excessive amounts of the metal in the body can potentially be quite toxic.…”

Section: Introductionmentioning

confidence: 99%

Trace elements zinc, copper, magnesium, and rubidium in pregnant Bulgarian women from an iodine-deficiency endemic region

Bacelova

Gatseva

Deneva

et al. 2022

Preprint

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Trace elements are essential for the biochemistry of the cell. Their reference values have been found to differ considerably in pregnant women stratified by age, place of residence, anthropometric status, and length of pregnancy. In optimal amounts, these elements reduce the risk of pregnancy complications. Subclinical hypothyroidism in pregnancy is associated with adverse maternal and neonatal outcomes. We aimed at determining the effects of Zn, Cu, Mg, and Rb on pregnant women in an iodine deficiency endemic region and find their relationship with the thyroid status and nutrition. We evaluated the iodine status of 61 healthy pregnant women from an endemic region in Bulgaria. TSH and FT4 levels were measured using ELISA. We found elevated levels of copper that differed the most between the first and second trimesters; Cu and TSH were found to be positively correlated (р<0.05). Lower Cu levels were found in pregnant women consuming pulses more than 2–3 times a week (р=0.033). The women consuming fish more than 2–3 times a week had higher levels of Rb. We found a pronounced iodine deficiency in more than half of the examined women in the first to third trimesters, without any effect of pregnancy on the ioduria (р=0.834). All second and third trimester cases were associated with severe ioduria (< 150 µg/L). The high Cu levels were associated with SCH and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.

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Serum levels of copper, iron, and manganese in women with pregnancy, miscarriage, and primary infertility

Cited by 43 publications

References 53 publications

Correlation of Abortus Imminence Cases in the First Trimester with Biochemical Markers

Correlation of Abortus Imminence Cases in the First Trimester with Biochemical Markers

Emerging Trends in Research on Food Compounds and Women’s Fertility: A Systematic Review

Trace elements zinc, copper, magnesium, and rubidium in pregnant Bulgarian women from an iodine-deficiency endemic region

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