Serum levels of endothelial monocyte activating polypeptide-II in type 1 diabetes patients with microangyopathy and arterial hypertention.

Mogylnytska, L. A.; Mankovsky, Boris

doi:10.14341/dm7674

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Therefore, advancing our understanding of the effects of age‐associated diseases such as T2D and HTN on cytokine responses during prolonged work represents an emerging area of interest. Previous findings demonstrate that serum EMAP‐II concentrations are higher in individuals with T2D independently of obesity 22 and in individuals with type 1 diabetes 21 . Conversely, we show that baseline serum EMAP‐II concentrations are similar between healthy older men with and without T2D or HTN.…”

Section: Discussioncontrasting

confidence: 65%

“…Conversely, we show that baseline serum EMAP‐II concentrations are similar between healthy older men with and without T2D or HTN. The factors underlying these discordant findings remain unclear, however, Mogylnytska and Mankovsky 22 also showed that serum EMAP‐II positively correlated with hemoglobin A1c, blood glucose, body mass index, and several blood lipids, suggesting that EMAP‐II concentrations may be modulated by the progression or severity of disease states. Additionally, our findings demonstrate that the presence of T2D blunts the EMAP‐II response to prolonged moderate‐intensity exercise performed in the heat relative to older men with and without HTN.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 Current evidence suggests that EMAP-II and its precursor (pro-EMAP-II/p43) stimulate the gene expression of proinflammatory cytokines, such as a TNF, IL-8, and IL-1, and increases circulating levels of TNF, IL-1, and IL-6, 19,20 which have been implicated in the progression of heat-related injuries. 12 Additionally, serum concentrations of EMAP-II have been shown to be elevated in individuals with micro-vascular complications, 21,22 potentially playing a role in endothelial dysfunction 23 and consequently affecting the body's ability to thermoregulate in individuals with T2D or HTN by attenuating cutaneous vasodilation or whole-body heat loss. 6,24 However, the relationships between EMAP-II, exercise (work), environmental heat, the presence of chronic disease, and the confounding effect of natural aging have yet to be explored in depth.…”

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confidence: 99%

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Impacts of age, diabetes, and hypertension on serum endothelial monocyte‐activating polypeptide‐II after prolonged work in the heat

Journeay

McCormick

King

et al. 2023

American J Industrial Med

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Background: With rising temperature extremes, older workers are becoming increasingly vulnerable to heat-related injuries because of age-and diseaseassociated decrements in thermoregulatory function. Endothelial monocyteactivating polypeptide-II (EMAP-II) is a proinflammatory cytokine that has not yet been well-characterized during heat stress, and which may mediate the inflammatory response to high levels of physiological strain. Methods: We evaluated serum EMAP-II concentrations before and after 180 min of moderate-intensity work (200 W/m 2 ) in temperate (wet-bulb globe temperature [WBGT] 16°C) and hot (WBGT 32°C) environments in heat-unacclimatized, healthy young (n = 13; mean [SD]; 22 [3] years) and older men (n = 12; 59 [4] years), and unacclimatized older men with hypertension (HTN) (n = 10; 60 [4] years) or type 2 diabetes (T2D) (n = 9; 60 [5] years). Core temperature and heart rate were measured continuously.Results: In the hot environment, work tolerance time was lower in older men with HTN and T2D compared to healthy older men (both p < 0.049). While core temperature and heart rate reserve increased significantly (p < 0.001), they did not differ across groups. End-exercise serum EMAP-II concentrations were higher in young men relative to their older counterparts due to higher baseline levels (both p ≤ 0.02). Elevations in serum EMAP-II concentrations were similar between healthy older men and older men with HTN, while serum EMAP-II concentrations did not change in older men with T2D following prolonged work in the heat. Conclusion:Serum EMAP-II concentrations increased following prolonged moderate-intensity work in the heat and this response is influenced by age and the presence of HTN or T2D.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Impacts of age, diabetes, and hypertension on serum endothelial monocyte‐activating polypeptide‐II after prolonged work in the heat

Journeay

McCormick

King

et al. 2023

American J Industrial Med

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“…Such a comorbidity significantly increases the risk of severe cardiovascular complications [4][5]. The presence of hypertension in patients with type 1 diabetes is associated with an increase in the frequency of severe stages of diabetic nephropathy and retinopathy; on the other hand, diabetes significantly increases the risk of emergence and developing hypertension, and hypertension is associated with a high risk of insulin resistance and metabolic abnormalities [6]. When combined with hypertension and diabetes, the risk of CHD developing increases by 2-4 times, stroke -2-3 times, visual loss -10-25 times, renal insufficiency -15-20 times, gangrene of the lower extremities -20 times [7].…”

Section: Introductionmentioning

confidence: 99%

Unifferentiated Connective Tissue Dysplasia as a Potential Predictor of Arterial Hypertension Development in Patients With Type 2 Diabetes Mellitus

Sherstyuk

Nikolenko

2018

The Journal of v. N. Karazin Kharkiv National University, Series "Medicine"

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The article presents the results of studies of markers of connective tissue dysplasia and the content of the main fibroblast growth factor in blood plasma in patients with type 2 diabetes. The presence of significant correlations between the studied parameters with the occurrence and progression of hypertension in patients with type 2 diabetes is established. A regression model for predicting the development of arterial hypertension is proposed in patients with diabetes mellitus. The development of hypertension in patients with DM type 2 in combination with UCTD occurs earlier, is almost independent of the duration of diabetes, more pronounced hypertension is observed in patients with visceral and skeletal symptoms of UCTD. This is evidence of the role of UCTD in the pathogenesis of hypertension in patients with type 2 diabetes. Essential role in the emergence and progression of hypertension in patients with DM type 2 is played by metabolic disorders of the connective tissue that manifests as clinical signs of UCTD. FGF2, which content is increased in patients with visceral and/or skeletal symptoms of UCTD, is involved in its pathogenesis. The regression model of the prediction of hypertension in patients with DM type 2 with an assessment of the presence of UCTD signs and the duration of diabetes has a high prognosticity, specificity and sensitivity, which makes it possible to apply this method in clinical practice to determine patients with high risk of development of hypertension.

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Markers of Endothelial Dysfunction as Predictors of Complicated Acute Myocardial Infarction in Combination with Type 2 Diabetes Mellitus

Feldman¹,

Ryndina²,

Кравчун³

2020

Ukr. ž. med. bìol. sportu

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Today, the endothelium is considered to be a multifunctional organ and a non-specific marker in the pathogenesis of diseases of the cardiovascular system. The course of diseases of the cardiovascular system depends on the presence of comorbid pathology, where type 2 diabetes is one of the possible representations of such pathology. The purpose of the study was to determine the diagnostic role of marker of endothelial dysfunction in patients with acute myocardial infarction with concomitant type 2 diabetes mellitus with regard to the clinical course of comorbid conditions. Material and methods. The study design consisted of 120 patients. They were divided into 2 groups: Group 1 consisted of patients with acute myocardial infarction and concomitant type 2 diabetes (n=69), Group 2 consisted of patients with acute myocardial infarction without concomitant type 2 diabetes (n=51). Patients of both groups matched on age and sex (60 men (50%) and 60 women (50%); their average age was 66.35±0.91 years, р<0,05). The control group consisted of 20 almost healthy people, among them 12 women (60%) and 8 men (40%) (average age was equal to 45.17±2.88 years). Examination of patients was conducted on the basis of Municipal Non-profit Enterprise "City Clinical Hospital No. 27" of Kharkiv City Council in the department of cardiology for patients with acute myocardial infarction. Diagnoses were determined according to the current criteria. All patients enrolled in the study signed a voluntary informed consent to participate in it. All patients underwent general clinical and instrumental examinations. The level of endothelial monocyte-activating polypeptide II in participants of the study was determined on the first day of acute myocardial infarction by using a commercial test system "Human Endothelial monocyte activating polepeptide II ELISA KIT". Results and discussion. According to the results of the study, in patients with acute myocardial infarction in combination with type 2 diabetes the levels of endothelial monocyte-activating polypeptide II was higher than in patients without concomitant type 2 diabetes by 1.65 times (p <0.05). The course of the study revealed the level of endothelial monocyte-activating polypeptide II, which was marked by high risk of cardiogenic shock and acute left ventricular failure. Having analyzed the parameter of endothelial dysfunction in terms of mortality, the researchers made the following conclusion: the endothelial monocyte-activating polypeptide II values greater than 3.44 ng/ml were the predictor of cardiovascular death probability during 6 months. Conclusion. The results of analysis of endothelial function made with use of the marker of endothelial monocyte-activating polypeptide II in patients with acute myocardial infarction with concomitant type 2 diabetes showed that such indicator can be deemed as predictor in complicated comorbid conditions

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Serum levels of endothelial monocyte activating polypeptide-II in type 1 diabetes patients with microangyopathy and arterial hypertention.

Abstract: (5.23 ± 1.66 ng/ml and 1.25 ± 0.76ng/ml; respectively, р < 0.01) and with the group of patients with diabetes but without hypertension (5.23 ± 1.66 ng/ml and 3.63 ± 1.9 ng/ml; respectively, р < 0.01

Cited by 4 publications

References 17 publications

Impacts of age, diabetes, and hypertension on serum endothelial monocyte‐activating polypeptide‐II after prolonged work in the heat

Impacts of age, diabetes, and hypertension on serum endothelial monocyte‐activating polypeptide‐II after prolonged work in the heat

Unifferentiated Connective Tissue Dysplasia as a Potential Predictor of Arterial Hypertension Development in Patients With Type 2 Diabetes Mellitus

Markers of Endothelial Dysfunction as Predictors of Complicated Acute Myocardial Infarction in Combination with Type 2 Diabetes Mellitus

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