Serum levels of insulin, IGF‐1, and IGFBP‐1 in pre‐eclampsia and eclampsia

Abstract

IGF-1 was lower, and IGFBP-1 was higher in pre-eclamptic and eclamptic patients than controls, these alterations were related to the severity of pre-eclampsia.

Pregnancy, progesterone and progestins in relation to breast cancer risk

“…Progesterone levels are reported to be increased in preclamptic pregnancies [28,29], which are associated with a reduction in subsequent BC, particularly in older primiparas and in the first few years following delivery [12] (Table 1). However, relative to normal pregnancies, those complicated by preclampsia are also typified by decreased levels of estrogens [28,30] and IGF-I [28,31,32], and by elevated levels of androgens [28,30,33,34], IGF binding protein-1 [28,31], hCG [28,[35][36][37] and AFP [37,38] (Table 4). All these factors may act both individually and synergistically to decrease BC risk by reducing proliferative growth of mammary tissue and by inhibiting the malignant transformation of precancerous lesions or the promotion of occult neoplasms [12].…”

Decreased fractional urinary calcium excretion and serum 1,25-dihydroxyvitamin D and IGF-I levels in preeclampsia

“…On the other hand, it has been found that preeclampsia is associated with decreased circulating levels of insulinlike growth factor I (IGF-I) [10][11][12][13][14][15]. Interestingly, IGF-I is considered as a regulator of 1,25-(OH) 2 D synthesis, since it stimulates renal [16,17] and placental [18] calcitriol production.…”

Differential Effect of Insulin Like Growth Factor-I on Constriction of Human Uterine and Placental Arteries

“…Furthermore, some studies report low IGF-I levels in women who go on to develop preeclampsia (42,43) and those with established disease (44). In light of the findings of the current study, it is possible that this double insult may contribute to the abnormal blood flow associated with this condition.…”