Serum levels of neopterin and interleukin‐2 receptor in women with severe preeclampsia

Kaleli, İlknur; Kaleli̇, Babür; Demir, Melek; Yildirim, Basak; Cevahir, Nural; Demi̇r, Süleyman

doi:10.1002/jcla.20053

Cited by 19 publications

(12 citation statements)

References 29 publications

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“…27 Additional studies have found increases in placental and/or peripheral blood levels of the inflammatory cytokines IL-2, IL-12, IL-15, IL-18, and IFN-γ in hypertensive pregnant women. [28][29][30] In contrast, Freeman et al found that IL-10 and TNF-α serum levels increased from the first to the third trimester in control pregnancies to nearly the same degree as in women with hypertensive pregnancies. 31 These inconclusive and often contradictory findings reveal that our understanding of the factors contributing to hypertensive pregnancies is quite limited and may also represent differences in the etiology (i.e., excessive maternal immune system activation vs. placental insufficiency).…”

Section: Discussionmentioning

confidence: 80%

Immunosuppression Improves Blood Pressure and Endothelial Function in a Rat Model of Pregnancy-Induced Hypertension

Tinsley

Chiasson

South

et al. 2009

American Journal of Hypertension

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Section: Discussionmentioning

confidence: 80%

Immunosuppression Improves Blood Pressure and Endothelial Function in a Rat Model of Pregnancy-Induced Hypertension

Tinsley

Chiasson

South

et al. 2009

American Journal of Hypertension

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“…28, 29 Similar to our own study, Haeger et al and Kaleli et al reported that plasma NEO concentrations were elevated in women with preeclampsia compared to normal pregnant women. 30 31 In two different studies, Schrocksnadel et al reported that NEO levels are elevated in hypertensive pregnant women. 32, 33 More recent data showed that there were no significant differences in NEO concentrations between normal pregnant women and women with preeclampsia between 18 and 38 weeks of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Inflammatory Markers Neopterin, Sialic Acid, and C-Reactive Protein in Pregnancy and Preeclampsia

Versen-Hoeynck

Hubel

Gallaher

et al. 2009

American Journal of Hypertension

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Objective To determine whether the cellular inflammatory marker of activated macrophages and monocytes, neopterin (NEO) and the acute phase inflammatory markers sialic acid (SA) and C-reactive protein (CRP) are elevated in pregnancy and further elevated in the pregnancy syndrome preeclampsia. Methods Maternal plasma concentrations of NEO, SA and CRP were measured by high sensitivity ELISA or HPLC in 20 non-pregnant women, 40 women with uncomplicated pregnancies, 50 women with transient hypertension of pregnancy alone, 49 women with small for gestational age (SGA) infants without preeclampsia, and 47 women with preeclampsia. Results The mean concentration of plasma NEO, SA and CRP were all significantly elevated in all groups of pregnant women compared to non-pregnant women (p<0.001 for all). In addition, maternal plasma NEO concentrations were further elevated in women with preeclampsia compared to the other groups of pregnant women (p<0.01). As expected, the acute phase inflammatory markers CRP and SA correlated positively with each other. However, CRP was also correlated with the activated macrophage and monocyte marker NEO in women with transient hypertension of pregnancy and women with preeclampsia (p<0.05). Conclusion The inflammatory markers NEO, SA and CRP are all elevated during pregnancy. However, only NEO, a marker of macrophage and monocyte activation, was further elevated in women with preeclampsia. These data suggest that there is a striking increase in inflammation during pregnancy, and cellular immune activation is further elevated during preeclampsia.

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“…We have previously reported that PDS rats exhibit increased serum levels of the proinflammatory cytokines IL-2, IL-12, and IFN␥ and the chemokine RANTES on gestational day 20 (34), similar to women with PE compared with NP women (4,5,7,16,17,27). Here we report that rats treated with DOCA/saline during pregnancy also exhibit significantly increased serum levels of endothelin-1, which may contribute to the decreased endothelial function and increased systolic blood pressure evident in these rats.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats

Tinsley

South

Chiasson

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

100

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Tinsley JH, South S, Chiasson VL, Mitchell BM. Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol 298: R713-R719, 2010. First published January 6, 2010 doi:10.1152/ajpregu.00712.2009.-Hypertensive disorders of pregnancy are characterized by systemic and placental inflammation; however, treatment for these conditions has remained elusive. We tested whether administration of the anti-inflammatory cytokine interleukin-10 (IL-10) during pregnancy would attenuate the hypertension, endothelial dysfunction, proteinuria, and inflammation seen in pregnant DOCA/saline-treated (PDS) rats. Normal pregnant (NP) rats and PDS were given daily intraperitoneal injections of recombinant IL-10 from gestational day 13 until death on day 20. Systolic blood pressure, aortic endothelium-dependent relaxation responses, and urinary protein excretion were measured on days 13 and 20 of gestation. Fetal number and development, plasma endothelin-1 levels, serum and placental levels of IFN␥ and IL-10, and aortic and placental levels of platelet endothelial cell adhesion molecule (PECAM) were assessed on gestational day 20. Systolic blood pressure, aortic endothelial dysfunction, and urinary protein excretion were significantly increased at gestational day 13 in PDS rats. However, all of these were restored to NP levels following IL-10 treatment in PDS rats. IL-10 treatment also significantly increased the number of pups per litter in PDS rats and did not further affect fetal development. The beneficial effects of IL-10 in PDS rats were likely mediated by the decreased plasma levels of endothelin-1, decreased levels of circulating and placental IFN␥, as well as decreased aortic and placental expression of PECAM. These data demonstrate that exogenous IL-10 can normalize blood pressure and endothelial function in pregnancy-induced hypertensive rats and may be beneficial in women with hypertensive disorders of pregnancy. preeclampsia; anti-inflammatory; hypertension; endothelin-1 PREECLAMPSIA (PE), DIAGNOSED as de novo hypertension and proteinuria during pregnancy, and other hypertensive disorders of pregnancy affect ϳ10% of pregnancies in the US and are responsible for 15-20% of maternal deaths worldwide (8). PE is associated with decreased fetal development and increased risk of future maternal heart disease. Although recent scientific findings have greatly aided in explaining the potential mechanisms involved in the development of PE, the exact causes remain unknown and effective treatments for PE remain elusive.Abnormal maternal immune system responses play a key role in the development of PE (10,13,31). A current theory is that women who develop PE have abnormal immunological responses to the fetus and placenta and that the hypertension and proteinuria represent clinical signs of a mild form of fetal rejection, while severe forms of PE result in spontaneous abortion and fetal demise. Consistent with this abnormal immunological response, cli...

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Serum levels of neopterin and interleukin‐2 receptor in women with severe preeclampsia

Cited by 19 publications

References 29 publications

Immunosuppression Improves Blood Pressure and Endothelial Function in a Rat Model of Pregnancy-Induced Hypertension

Immunosuppression Improves Blood Pressure and Endothelial Function in a Rat Model of Pregnancy-Induced Hypertension

Plasma Levels of Inflammatory Markers Neopterin, Sialic Acid, and C-Reactive Protein in Pregnancy and Preeclampsia

Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats

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