Serum levels of nitric oxide and its correlation with endothelial nitric oxide synthase gene expression among type 2 diabetic patients with or without hypertension: A comparative study in a tertiary care hospital of North East India

Goswami, Bidhan; Sarkar, S. K.; Bhattacharjee, Bhaskar; Sengupta, Shauli

doi:10.4103/jnsbm.jnsbm_205_20

Cited by 8 publications

(6 citation statements)

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“…An imbalance in the synthesis and/or the release and/or action of these endothelial factors has been linked to endothelial dysfunction (Chistiakov, Revin, Sobenin, Orekhov, & Bobryshev, 2015; Félétou, 2011; Shimokawa, 2014; Vanhoutte, Shimokawa, Feletou, & Tang, 2017). Endothelial dysfunction is a key player in the initiation and progression of metabolic disorders such as cardiovascular disease (CVD) (Chistiakov et al, 2015; Goswami, Sarkar, Bhattacharjee, & Sengupta, 2021).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta‐analysis of randomized controlled trials

Mohammadipoor

Shafiee

Rostami

et al. 2022

Phytotherapy Research

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We perform a systematic review and meta‐analysis of randomized controlled trials (RCTs) to quantify the effect of resveratrol supplementation on endothelial function. A comprehensive search was performed in electronic databases including PubMed, Scopus, Web of Science, and Cochrane Library up to February 2021 with no limitation in time and language. A meta‐analysis of eligible studies was performed using a random‐effects model to estimate the pooled effect size of flow‐mediated dilation (FMD), intracellular adhesion molecule‐1 (ICAM‐1), vascular adhesion molecule‐1 (VCAM‐1), fibrinogen, and plasminogen activator inhibitor‐1 (PAI‐1). In total, 21 arms from 17 studies were included. The meta‐analysis results showed that resveratrol significantly change the concentrations of FMD (WMD: 1.43%; 95% CI: 0.98 to 1.88, p < .001) and ICAM‐1 (WMD: −7.09 ng/ml, 95% CI: −7.45 to −6.73, p < .001). However, VCAM‐1, fibrinogen, and PAI‐1 did not change significantly after resveratrol supplementation. In conclusion, the results of this study suggest that resveratrol supplementation can improve endothelial function which could be important, especially in patients with cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta‐analysis of randomized controlled trials

Mohammadipoor

Shafiee

Rostami

et al. 2022

Phytotherapy Research

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“…Different classes of antihypertensive drugs are available; however, good BP control is obtained in less than one‐third of patients (Sahebkar, 2014; Saugel & Sessler, 2021). There are still some problems in BP management such as poor medication compliance, medication side effects, and high medication costs (Burnier, Polychronopoulou, & Wuerzner, 2020; Goswami, Sarkar, Bhattacharjee, & Sengupta, 2021; Nies, 1975; Waeber, Burnier, & Brunner, 1999). In recent years, there has been a growing interest and demand for the use of medicinal plants for managing BP reducing the burden of HTN (Ahmad et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized clinical trials

Mahmudiono

Jasim

Karim

et al. 2022

Phytotherapy Research

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We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random‐effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta‐analysis of five trials (6 arms) showed significant reductions in systolic (WMD: −3.86 mmHg, 95% CI: −7.59 to −0.13, p = .04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: −1.71 mmHg, 95% CI: −3.67 to 0.26, p = .09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.

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“…Existing research recognizes the pathophysiological association between hypertension and diabetes, 7 , 8 demonstrating that elevated BP increases the risk of diabetes, 9–11 while a higher FPG level is an independent risk factor for hypertension. 12 , 13 Those strong pathophysiological links make hypertensive patients with diabetes have a significantly higher risk of target organ damage and cardiovascular death than those with a single condition.…”

Section: Introductionmentioning

confidence: 99%

“…4 According to the Chinese epidemiological survey, the detection rate of hypertension in diabetic patients in China is about 49.4%, and the detection rate of diabetes in hypertensive patients is 19.5%. 5,6 Existing research recognizes the pathophysiological association between hypertension and diabetes, 7,8 demonstrating that elevated BP increases the risk of diabetes, [9][10][11] while a higher FPG level is an independent risk factor for hypertension. 12,13 Those strong pathophysiological links make hypertensive patients with diabetes have a significantly…”

Section: Introductionmentioning

confidence: 99%

Trends and Comparisons of Blood Pressure and Fasting Plasma Glucose in Patients with Hypertension, Diabetes, and Comorbidity: 4-Year Follow-Up Data

Xu¹,

Wen²,

Yang³

et al. 2022

RMHP

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Background Patients with both diabetes and hypertension could face more health risks than those with either condition alone, and less attention has been paid to their management outcomes, so this study may be the first to specifically address this problem. We aimed to examine the management outcomes of blood pressure (BP) in hypertensive patients with/without diabetes and fasting plasma glucose (FPG) in diabetic patients with/without hypertension. Methods Follow-up data were obtained from the National Basic Public Health Service Project in Sanming (2017–2021). A total of 25,795 adults with hypertension only, 4111 adults with diabetes only, and 5729 comorbid adults (namely, hypertensive patients with diabetes) were included. Generalized estimating equations were applied. Results Systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with hypertension only both dropped significantly (Coef. = −0.00088, P < 0.001; Coef. = −0.00081, P < 0.001). DBP in comorbid patients decreased considerably (Coef. = −0.00033, P < 0.001). Pulse pressure in comorbid patients grew rapidly (Coef. = 0.00044, P < 0.001). BP control rate in patients with hypertension only increased significantly (OR = 1.00039, P < 0.001). FPG control rates in diabetic patients with/without hypertension grew markedly (OR = 1.00013, P < 0.001; OR = 1.00020, P < 0.001). Comorbid patients had lower baseline SBP and DBP but higher latest SBP than patients with hypertension only (Coef. = −1.18872, P < 0.001; Coef. = −1.16049, P < 0.001; Coef. = 1.0634, P < 0.001). Comorbid patients had lower baseline BP and FPG control rates than those with either condition alone, and differences were greater at the latest follow-up (OR = 0.28086, P < 0.001; OR = 0.91012, P = 0.049; OR = 0.04020, P < 0.001; OR = 0.69465, P < 0.001). Conclusion BP and FPG management outcomes have achieved progress. Comorbid patients have poorer performance than patients with either disease alone in BP levels especially the SBP level and control rates of SBP, DBP, and FPG. Future studies should be conducted using national data and include more confounding factors.

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Serum levels of nitric oxide and its correlation with endothelial nitric oxide synthase gene expression among type 2 diabetic patients with or without hypertension: A comparative study in a tertiary care hospital of North East India

Cited by 8 publications

References 0 publications

Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta‐analysis of randomized controlled trials

Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta‐analysis of randomized controlled trials

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized clinical trials

Trends and Comparisons of Blood Pressure and Fasting Plasma Glucose in Patients with Hypertension, Diabetes, and Comorbidity: 4-Year Follow-Up Data

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