Serum levels of nitric oxide and cytokines in smokers at the beginning and after 4months of treatment for smoking cessation

Keulen, Henriqueta Vieira van; Gomes, Antoniella S.; Oliveira, Érick Esteves de; Silva, L.C; Alves, Cléber R.; Almeida, Caroline de Souza; Dutra, Sheila Cristina Potente; Aguiar, Aline Silva de; Ferreira, Ana Paula

doi:10.1016/j.ijcard.2016.12.111

Cited by 12 publications

(11 citation statements)

References 26 publications

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“…However, Rodrigues et al [21] found that quitters and active smokers had similar IL-6, IL-8, and IL-10 levels, and they mentioned that 30 days was a relatively short period for quitting. Similarly, Van Keulen et al [47] found in their study in Brazil that serum levels of TNF-α, IL-1, IL-6, IL-8, IL-10 and IL-12 were similar at 4 th month of quitting when compared to basal levels. In the present study, serum IL-6 and IL-10 levels did not change significantly at 2 nd month of quitting, when compared to basal levels.…”

Section: Discussionmentioning

confidence: 69%

Changes in systemic inflammatory and nasal mucociliary response following smoking cessation

Solak¹

2018

South Clin Ist Euras

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Section: Discussionmentioning

confidence: 69%

Changes in systemic inflammatory and nasal mucociliary response following smoking cessation

Solak¹

2018

South Clin Ist Euras

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“…Paradoxically, smoking results in immunosuppression as well as aggravated autoimmunity. Altered levels of inflammatory cytokines like TNF-α, IFN-γ, IL-1β, IL-6, IL-8, IL-10, and others have been reported in healthy smokers (39)(40)(41)(42). A possible explanation for the connection between active smoking and a lower risk for esophagitis or pneumonitis is that long-term cigarette smoking leads to an increased immune response in the lung and surrounding tissues due to the damage it inflicts on the lung parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Predictive Modeling of Thoracic Radiotherapy Toxicity and the Potential Role of Serum Alpha-2-Macroglobulin

Reibnitz

Yorke

et al. 2020

Front. Oncol.

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Background: To investigate the impact of alpha-2-macroglobulin (A2M), a suspected intrinsic radioprotectant, on radiation pneumonitis and esophagitis using multifactorial predictive models. Materials and Methods: Baseline A2M levels were obtained for 258 patients prior to thoracic radiotherapy (RT). Dose-volume characteristics were extracted from treatment plans. Spearman's correlation (Rs) test was used to correlate clinical and dosimetric variables with toxicities. Toxicity prediction models were built using least absolute shrinkage and selection operator (LASSO) logistic regression on 1,000 bootstrapped datasets. Results: Grade ≥2 esophagitis and pneumonitis developed in 61 (23.6%) and 36 (14.0%) patients, respectively. The median A2M level was 191 mg/dL (range: 94-511). Never/former/current smoker status was 47 (18.2%)/179 (69.4%)/32 (12.4%). We found a significant negative univariate correlation between baseline A2M levels and esophagitis (Rs = −0.18/p = 0.003) and between A2M and smoking status (Rs = 0.13/p = 0.04). Further significant parameters for grade ≥2 esophagitis included age (Rs = −0.32/p < 0.0001), chemotherapy use (Rs = 0.56/p < 0.0001), dose per fraction (Rs = −0.57/p < 0.0001), total dose (Rs = 0.35/p < 0.0001), and several other dosimetric variables with Rs > 0.5 (p < 0.0001). The only significant non-dosimetric parameter for grade ≥2 pneumonitis was sex (Rs = −0.32/p = 0.037) with higher risk for women. For pneumonitis D15 (lung) (Rs = 0.19/p = 0.006) and D45 (heart) (Rs = 0.16/p = 0.016) had the highest correlation. LASSO models applied on the validation data were statistically significant and resulted in areas under the receiver operating characteristic curve of 0.84 (esophagitis) and 0.78 (pneumonitis). Multivariate predictive models did not require A2M to reach maximum predictive power. Conclusion: This is the first study showing a likely association of higher baseline A2M values with lower risk of radiation esophagitis and with smoking status. However, the baseline A2M level was not a significant risk factor for radiation pneumonitis.

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“…35 Cigarette smoke may also affect levels of vascular endothelial nitric oxide, and can also modulate inflammatory reactions through inflammatory cytokines. 36 Additionally, ONO • can react with other gaseous components of cigarette smoke (such as isoprene) to form alkoxyl radicals. These peroxyl radicals then react with either NO • or ONOO – to form peroxynitrate radicals.…”

Section: Discussionmentioning

confidence: 99%

Comparative assessment of individual RONS in serum of smokers compared with non-smokers and their correlation with the lipid profile and antioxidant status

Khojah

Ahmed

2019

J Int Med Res

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Objective Cigarette smoking generates free radicals, such as reactive oxygen and nitrogen species (RONS) that contribute to many diseases. The aim of this study was to compare the levels of individual RONS in serum from smokers and non-smokers, and to examine their impact on lipid profiles and the endogenous antioxidant status, which is represented by vitamins C and E. Methods Ninety-four healthy Egyptian volunteers (48 smokers and 46 non-smokers) were enrolled. Blood samples were collected and analysed for common haematological tests, lipid profiles, and serum antioxidants. Six reactive oxygen species and three reactive nitrogen species were measured. Results A significant increase in radical levels was observed, as well as significant increases in haemoglobin (Hb), haematocrit, platelet count, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol in smokers compared with non-smokers. In contrast, high-density lipoprotein cholesterol was significantly reduced in smokers compared with non-smokers. A moderate negative correlation was found between serum levels of vitamins C and E and O2–•, HO•, H2O2, NO•, and ONO•, reflecting a negative impact of elevated RONS levels on the endogenous antioxidant status. Conclusion These results may increase our understanding of the pathological role of smoking in several diseases.

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Serum levels of nitric oxide and cytokines in smokers at the beginning and after 4months of treatment for smoking cessation

Cited by 12 publications

References 26 publications

Changes in systemic inflammatory and nasal mucociliary response following smoking cessation

Changes in systemic inflammatory and nasal mucociliary response following smoking cessation

Predictive Modeling of Thoracic Radiotherapy Toxicity and the Potential Role of Serum Alpha-2-Macroglobulin

Comparative assessment of individual RONS in serum of smokers compared with non-smokers and their correlation with the lipid profile and antioxidant status

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