Serum levels of resistin and its correlation with adiponectin and insulin in healthy full term neonates

Mamì, C; Marseglia, Lucia; Manganaro, R; Saitta, Giuseppe; Martino, Francesco De; Gargano, Romana; Gemelli, Marina

doi:10.1016/j.earlhumdev.2008.05.011

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…15 However, in others no correlation was found. [16][17][18]20,21 In our study, no correlation was found between resistin levels and gestational age or birth weight of the babies. Median resistin levels (28.3 ng ml -1 ) of our study is somewhat higher than the levels (8 to 21 ng ml -1 ) reported in previous studies, such as the levels of IL-6 (20.5 pg ml -1 ) for which the cutoff value to consider a fetus as having a fetal inflammatory response syndrome was determined to be >11 pg ml -1 .…”

Section: Discussioncontrasting

confidence: 75%

“…[12][13][14][15][16] Resistin was suggested to be involved in the maintenance of neonatal metabolic homeostasis. 15 Its levels in neonates changed between 8 and 21 ng ml -1 , 12,15,17 and were reported to be higher than maternal levels. 15,18 It was also detected in amniotic fluid starting from the 14th week of gestation in which levels increased with advancing gestational age and at term the levels reached to 23.6 ng ml -1 .…”

Section: Discussionmentioning

confidence: 96%

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Resistin levels in preterms: are they influenced by fetal inflammatory course?

et al. 2010

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Objective: Many different factors are involved in the pathogenesis of preterm deliveries and among them maternal or perinatal infections and inflammatory response have the major role. Researches were carried out about resistin, which is thought to have a role in inflammatory cytokine cycle and it was shown to be associated with growth in neonates. However, no research has been carried out showing its relationship with inflammation in neonates. In this study, we aimed to evaluate the resistin levels in premature neonates and the effect of events such as preterm prelabour rupture of the membranes (PPROMs) and the use of antenatal steroids on these levels.Study Design: The study included 118 preterm neonates. Their medical data together with their mothers' were recorded. Serum resistin levels together with interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin were evaluated in the first 2 h of life.Result: Mean gestational age and birth weight of babies included in the study were 29.6 ± 2.7 weeks and 1306.4 ± 393.4 g, respectively. Babies with PPROMs had significantly higher levels of resistin ((n ¼ 30); 70.7 (7.8 to 568.4) ng ml -1 ) than babies without PPROM ((n ¼ 88); 25.9 (5.5 to 528.9) ng ml -1 ) (P ¼ 0.005), and the babies of mothers who received antenatal steroids had significantly lower resistin levels ((n ¼ 44); 20.8 (5.5 to 159.9) ng ml -1 ) than the babies of mothers who did not ((n ¼ 66); 34.6 (7.2 to 568.4) ng ml -1 ) (P ¼ 0.015). There were significant correlations between resistin and IL-6 levels and between IL-6 and procalcitonin and CRP levels in babies whose mothers did not receive antenatal steroids. However, no correlation was found between these parameters in babies whose mothers received antenatal steroids.Conclusion: Preterm delivery and PPROM involve complex cascade of events including inflammation, and steroids are potent anti-inflammatory agents. Elevated resistin levels in babies with PPROM and suppressed levels in babies whose mothers received antenatal steroids reported in this study might have been observed as a result of the effects of fetal inflammation on resistin levels.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Resistin levels in preterms: are they influenced by fetal inflammatory course?

et al. 2010

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“…91 Maternal resistin levels decrease during lactation and seems also to be involved in appetite regulation and energy balance. 92 It would appear to promote release of hormonal and inflammatory molecules (such as estradiol, progesterone, thyroxine, triiodothyronine, cortisol, prolactin, leptin, and Creactive protein). 93 Conversely to obese mice, human resistin is not directly involved in insulin sensitivity or adipogenesis.…”

Section: Resistinmentioning

confidence: 99%

Obesity and breastfeeding: The strength of association

et al. 2015

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“…These findings suggest that this hormone may play a role in maintenance of metabolic neonatal homeostasis [91]. In a sample of 37 neonates born at term mean, umbilical serum resistin concentration was 21.34 ± 1.07 ng/mL, ranging from 10.61 to 40.81 ng/mL [92].…”

Section: Resistinmentioning

confidence: 99%

Breast Milk Hormones and Regulation of Glucose Homeostasis

Savino

Liguori

Sorrenti

et al. 2011

International Journal of Pediatrics

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Growing evidence suggests that a complex relationship exists between the central nervous system and peripheral organs involved in energy homeostasis. It consists in the balance between food intake and energy expenditure and includes the regulation of nutrient levels in storage organs, as well as in blood, in particular blood glucose. Therefore, food intake, energy expenditure, and glucose homeostasis are strictly connected to each other. Several hormones, such as leptin, adiponectin, resistin, and ghrelin, are involved in this complex regulation. These hormones play a role in the regulation of glucose metabolism and are involved in the development of obesity, diabetes, and metabolic syndrome. Recently, their presence in breast milk has been detected, suggesting that they may be involved in the regulation of growth in early infancy and could influence the programming of energy balance later in life. This paper focuses on hormones present in breast milk and their role in glucose homeostasis.

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Serum levels of resistin and its correlation with adiponectin and insulin in healthy full term neonates

Cited by 15 publications

References 23 publications

Resistin levels in preterms: are they influenced by fetal inflammatory course?

Resistin levels in preterms: are they influenced by fetal inflammatory course?

Obesity and breastfeeding: The strength of association

Breast Milk Hormones and Regulation of Glucose Homeostasis

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