Resistin levels in preterms: are they influenced by fetal inflammatory course?

Abstract

Objective: Many different factors are involved in the pathogenesis of preterm deliveries and among them maternal or perinatal infections and inflammatory response have the major role. Researches were carried out about resistin, which is thought to have a role in inflammatory cytokine cycle and it was shown to be associated with growth in neonates. However, no research has been carried out showing its relationship with inflammation in neonates. In this study, we aimed to evaluate the resistin levels in premature neonates and the effect of events such as preterm prelabour rupture of the membranes (PPROMs) and the use of antenatal steroids on these levels.Study Design: The study included 118 preterm neonates. Their medical data together with their mothers' were recorded. Serum resistin levels together with interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin were evaluated in the first 2 h of life.Result: Mean gestational age and birth weight of babies included in the study were 29.6 ± 2.7 weeks and 1306.4 ± 393.4 g, respectively. Babies with PPROMs had significantly higher levels of resistin ((n ¼ 30); 70.7 (7.8 to 568.4) ng ml -1 ) than babies without PPROM ((n ¼ 88); 25.9 (5.5 to 528.9) ng ml -1 ) (P ¼ 0.005), and the babies of mothers who received antenatal steroids had significantly lower resistin levels ((n ¼ 44); 20.8 (5.5 to 159.9) ng ml -1 ) than the babies of mothers who did not ((n ¼ 66); 34.6 (7.2 to 568.4) ng ml -1 ) (P ¼ 0.015). There were significant correlations between resistin and IL-6 levels and between IL-6 and procalcitonin and CRP levels in babies whose mothers did not receive antenatal steroids. However, no correlation was found between these parameters in babies whose mothers received antenatal steroids.Conclusion: Preterm delivery and PPROM involve complex cascade of events including inflammation, and steroids are potent anti-inflammatory agents. Elevated resistin levels in babies with PPROM and suppressed levels in babies whose mothers received antenatal steroids reported in this study might have been observed as a result of the effects of fetal inflammation on resistin levels.

Adipokines in Childhood Obesity

“…Resistin levels are higher in cord blood from preterm compared to full-term pregnancies (Martos-Moreno et al, 2009), which could be due to the higher prevalence of a proinflammatory environment in preterm pregnancies, as observed in cases with prelabor rupture of the placental membranes (Gursoy, Aliefendioglu, Caglayan, Aktas, & Ovali, 2011). This is supported by the positive correlation between resistin and proinflammatory cytokine levels in cord blood, as well as by the suppression of resistin observed in mothers receiving antenatal steroids (Gursoy et al, 2011;Martos-Moreno et al, 2009).…”

Resistin—A Novel Feature in the Diagnosis of Sepsis in Premature Neonates

“…Correlations between resistin levels and other inflammatory markers, including IL-6, leptin, TNF-α, CRP, and PCT, have been reported in patients with severe inflammatory disease, sepsis, and septic shock. [9][10][11][12][13][14][15] To our knowledge, no study to date has evaluated the diagnostic value of resistin in sepsis in preterm infants. Therefore, we aimed to evaluate the potential of resistin in the diagnosis of sepsis in preterm infants, for comparison with CRP results, and to evaluate the resistin levels in gramnegative sepsis (GNS) and gram-positive sepsis (GPS).…”

Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction

“…In a study by Martos-Moreno et al [48], preterm neonates had higher resistin levels than full-term neonates. Conversely, some authors observed decreased resistin concentrations in preterm infants, compared with full-term infants [60], whereas resistin levels were not correlated with GA in another study [61]. Beyond birth, some reports found that resistin levels were similar between preterm and full-term children at school age [53,62].…”