Serum Levels of Retinol and Other Antioxidants for Hearing Impairment Among Japanese Older Adults

Michikawa, Takehiro; Nishiwaki, Yuji; Kikuchi, Yuriko; Hosoda, Kanae; Mizutari, Kunio; Saya, Hideyuki; Asakura, Keiko; Milojevic, Ai; Iwasawa, Satoko; Nakano, Makiko; Takebayashi, Toru

doi:10.1093/gerona/glp038

Cited by 37 publications

(41 citation statements)

References 28 publications

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“…Our findings are in agreement with an animal study showing that retinoic acid (an active metabolite of retinol) prevented noise-induced hearing loss (23). These data also concur with a recent cross-sectional Japanese study of 762 adults aged 65 years or older (21). In this study, Michikawa et al showed that serum levels of retinoic acid were inversely related to the prevalence of hearing impairment.…”

Section: Discussionsupporting

confidence: 93%

“…As the concentration of vitamin A (retinol equivalents) in the inner ear has been observed to be high (21,22), the association between vitamin A and the prevention of hearing loss has been investigated. In our cohort, we observed that participants in the highest quintile of vitamin A intake compared with the remaining population were 47% less likely to have moderate or greater hearing loss (>40 dB HL).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary antioxidant intake is associated with the prevalence but not incidence of age-related hearing loss

Gopinath

Flood

McMahon

et al. 2011

The Journal of nutrition, health and aging

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Dietary antioxidant intake is associated with the prevalence but not incidence of age-related hearing loss

Gopinath

Flood

McMahon

et al. 2011

The Journal of nutrition, health and aging

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show abstract

“…Hyperlipoproteinemia has been reported to cause anoxia in the sensitive cells of the inner ear and possible development of sudden fluctuating or progressive hearing and vestibular disorders related to this [15,20]. Saito et al [15] found that a high fat containing diet caused a 40% increase in the hearing threshold in their study carried out with guinea pigs.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Metabolic Presbycusis and Serum Paraoxonase/Arylesterase Activity

Keleş

Kapusuz

Gürsu

et al. 2011

Indian J Otolaryngol Head Neck Surg

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To determine the presence of a relationship between metabolic presbycusis and serum paraoxonase/ arylesterase activity. A total of 30 patients who had been admitted to the Ear, Nose, and Throat (ENT) Clinic of Fırat University Medical Faculty and diagnosed as metabolic presbycusis were included in the study. The control group was composed of 30 healthy volunteers. Pure tone audiometry and impedencemeter were performed on all subjects included in the study at the audiometry laboratory of the ENT clinic. The presence of a regular hearing curve, a symmetrical sensorineural hearing loss more than 25 dB with preserved speech discrimination were accepted as criteria for metabolic presbycusis. Blood samples were drawn from the patients prior to the hearing tests. The sera were separated for measurements of total cholesterol, triglyceride, high-density lipoprotein, very low-density lipoprotein, low-density lipoprotein, human serum paraoxonase and arylesterase levels, respectively. No statistically significant difference was found between the patient and the control groups in terms of age and gender. Paraoxonase, arylesterase and paraoxonase/arylesterase, high-density lipoprotein levels were found to decrease in the study group and the difference was found to be statistically significant compared to the control group (P \ 0.001). Low-density lipoprotein and total cholesterol levels were found to increase in the patient group and the difference was found to be significant compared to the control group (P \ 0.001). This study puts forth that especially the type of nutrition and life style are very important with regard to metabolic presbycusis. Furthermore, the results of this study make us think that there could be a relationship between metabolic presbycusis and cardiovascular diseases. In this case, metabolic presbycusis may be a determining parameter in the early diagnosis of cardiovascular diseases. We consider that this study may be the pioneer for further studies conducted with larger patient numbers.

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“…2 Cross-sectional association of serum concentrations of retinol, provitamin A carotenoids, and other antioxidants, with hearing impairment [28]. Odds ratios (ORs) of hearing impairment were adjusted for age, sex, smoking, alcohol consumption, hypertension, and total cholesterol.…”

Section: Risk or Preventive Factors For Sensory Impairmentsmentioning

confidence: 99%

Prevalence, adverse health, and risk factors in association with sensory impairments: data from a prospective cohort study of older Japanese

Michikawa

2016

Environ Health Prev Med

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Sensory impairments, mainly of vision and hearing, are prevalent among the older adults, and are the leading causes of disability in people aged 60 years and above around the world. However, epidemiological data on sensory impairments (prevalence, association with adverse health outcomes, risk and preventive factors, etc.) in community-dwelling older people are sparse in Japan. Using data from the Kurabuchi Study, a community-based prospective cohort study of adults aged 65 years or older, the author and colleagues estimated the prevalence of sensory impairments in this population. Vision and hearing impairments were associated with adverse health outcomes, such as depressive symptoms, dependence in activities of daily living, and early death. In addition, antioxidants, sunlight exposure, hyperglycaemia, and nutritional status were identified as possible risk or preventive factors for vision and/or hearing impairments. Further research is needed into whether the maintenance or improvement of sensory functions contributes to the extension of disability-free life expectancy.

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Serum Levels of Retinol and Other Antioxidants for Hearing Impairment Among Japanese Older Adults

Abstract: Increased serum levels of retinol and provitamin A carotenoids were clearly associated with a decreased prevalence of hearing impairment.

Cited by 37 publications

References 28 publications

Dietary antioxidant intake is associated with the prevalence but not incidence of age-related hearing loss

Dietary antioxidant intake is associated with the prevalence but not incidence of age-related hearing loss

The Relationship Between Metabolic Presbycusis and Serum Paraoxonase/Arylesterase Activity

Prevalence, adverse health, and risk factors in association with sensory impairments: data from a prospective cohort study of older Japanese

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