Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area

Silva, Cátia Carvalho; Gavinha, Sandra; Manso, Maria Conceição; Rodrigues, Rita; Martins, Sandra; Guimarães, João Tiago; Santos, Ana Cristina; Melo, Paulo

doi:10.3390/nu13010166

Cited by 21 publications

(39 citation statements)

References 48 publications

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“…Enamel and dentin abnormalities have been considered in children as caries risk factors. As a result, optimum vitamin D3 levels in children are required as a secondary preventive intervention for dental cavities in the permanent dentition [ 26 ]. Another study concluded that among the vitamin D3 receptor polymorphisms studied, a relation was found between the FokI polymorphism (rs10735810) and the risk of dental caries, with the protective effect of the f allele and ff genotype [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study

Al-Jubori¹,

AL-Murad²,

Al-Mashhadane³

2022

Cureus

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Aim Vitamin D3 plays an important role in affecting the overall remineralization process of the dentition. The use of supplements help to keep the levels at optimum and thus reduce the chances of treating very early lesion of caries. Hence the aim was to investigate the indirect effects of oral vitamin D3 on microhardness and elemental weight percentage of Calcium (Ca) and Phosphorous (P) in enamel surface with an artificially initiated carious lesion. Methods The 120 extracted premolars were randomly divided into five groups according to salivary immersion. Each group had a total of twenty-four participants, with the following characteristics: control +ve: sound enamel; control -ve: only subjected to pH cycle; A: pH cycle and immersion in control saliva; B: pH cycle and saliva collected after three weeks; and C: pH cycle and saliva collected after six weeks. The unstimulated saliva was collected from (40) adult volunteers receiving vitamin D3 1000IU gel capsules daily for six weeks. Before each vitamin D3 intake, 10 mL of unstimulated control saliva was collected from each participant. Then other 10 ml. were collected after three and six weeks of vitamin D receiving periods. Saliva immersion time (12 hours). Enamel surface was assessed by Vicker’s Microhardness machine and (X-ray fluorescence - XRF) spectrometer. Results For all specimens, there was a significant decrease in both (Ca and P weight %) after demineralization and then they significantly increased after receiving vitamin D3. The microhardness and elemental analysis provide confirmed results that were represented as a statistically significant difference at (P≤ 0.05) between groups that received vitamin D3 and those without vitamin D3 dosage. Conclusions Oral vitamin D3 has a significant potential in motivating remineralization of early lesions on the enamel surfaces representing improved surface microhardness and minerals content (Ca and P weight %) of demineralized tooth surfaces.

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Section: Discussionmentioning

confidence: 99%

Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study

Al-Jubori¹,

AL-Murad²,

Al-Mashhadane³

2022

Cureus

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“…The relationship between 25(OH)D and caries even extends beyond the primary dentition into the permanent dentition of children. A study of 7-year-olds in Portugal revealed that suboptimal 25(OH)D concentrations were significantly associated with advanced decay in permanent teeth [28]. A population-based prospective cohort study among mothers and children in the Netherlands reported that low maternal and neonatal 25(OH)D concentrations are associated with accelerated dental development of permanent teeth in children [29].…”

Section: Discussionmentioning

confidence: 99%

“…Over the last several years, the literature on the association between 25(OH)D and children's oral health has grown [5,22,26,28,29,36]. One recent study reported that lower prenatal and neonatal concentrations of 25(OH)D were associated with an advanced dental age of children, suggesting that inadequate 25(OH)D accelerates dental development [29].…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children

et al. 2021

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Background: Inadequate vitamin D levels may increase the risk of caries during childhood. The purpose of this study was to investigate the association between 25-hydroxyvitamin D (25(OH)D) status and severe early childhood caries (S-ECC) in preschool children. Methods: Data were obtained from children <72 months of age in two case–control studies in Winnipeg, Manitoba and Richmond, Virginia. Serum analysis assessed 25(OH)D, calcium and parathyroid concentrations. Data on demographics, dental history and oral hygiene were obtained via questionnaires. Bivariate and multiple logistic regression analyses were performed to assess the relationships between demographic and biological variables and S-ECC. A p-value of ≤0.05 was significant. Results: Data were available for 200 children with S-ECC and 144 caries-free controls. Children with S-ECC had significantly lower 25(OH)D levels than those who were caries-free (p < 0.001), and children with deficient 25(OH)D levels were 10 times more likely to have S-ECC (p < 0.001). Multiple logistic regression revealed that having higher 25(OH)D and calcium concentrations (p = 0.019 and p < 0.0001, respectively), as well as being breastfed in infancy (p < 0.001), were significantly and independently associated with lower odds of S-ECC, while dental insurance (p = 0.006) was associated with higher odds of S-ECC. Conclusions: This study provides additional evidence of an association between nutritional status, specifically vitamin D and calcium levels, and S-ECC.

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“…The relationship between nutrition, general health, and dental caries studies dates to the 1920s. The study by Mellanby and Pattison, published in 1928, provides the first evidence that vitamin D deficiency is associated with dental caries in children [7,8]. A growing body of studies and evidence shows that low serum concentrations of 25-hydroxyvitamin D (25(OH)D) are associated with increased caries experience [2,[8][9][10][11].…”

Section: Vitamin D Deficiency In Pediatric Dentistrymentioning

confidence: 99%

Vitamin D Deficiency in Pediatric Dentistry

Aydin¹

2023

Vitamin D Deficiency - New Insights

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Vitamin D (vitD) deficiency has essential effects on general health. It is known that oral and dental health is an integral part of public health, and there is a close relationship between them. From the development and eruption stages of the teeth to the formation of caries, vitD deficiency has accepted significant effects on oral health. It is essential to understand the role of vitD deficiency in early childhood caries (ECC), which is considered one of the most critical problems, especially in pediatric patients. Low vitD levels during pregnancy have even been reported to increase ECC risk in infancy. For this reason, care should be taken to ensure that the mother’s 25(OH)d level and later the child is in optimal conditions, starting from the pregnancy period, to improve the oral health status of children.

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Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area

Cited by 21 publications

References 48 publications

Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study

Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study

Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children

Vitamin D Deficiency in Pediatric Dentistry

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