Serum linoleic acid and cardiovascular death in postinfarction middle-aged men

Válek, J; Hammer, J; Kohout, M; Grafnetter, D; Vondra, K; Topinka, V.

doi:10.1016/0021-9150(85)90158-3

Cited by 26 publications

(5 citation statements)

References 16 publications

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“…In an effort to determine the elements that induce necrosis, we measured the cardiac free fatty acid species and determined that sunflower oil feeding increased cardiac n-6 PUFA, predominantly linoleic acid. In clinical studies, accumulation of linoleic acid has been strongly associated with an increased inflammatory response in endothelial cells, in addition to an augmented risk of myocardial infarction and necrosis (46). Additionally, in vitro, linoleic acid precipitates necrosis via proinflammatory pathways in various cell types (44,45).…”

Section: Discussionmentioning

confidence: 98%

Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA

Ghosh

Ding

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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Diabetic patients are particularly susceptible to cardiomyopathy independent of vascular disease, and recent evidence implicates cell death as a contributing factor. Given its protective role against apoptosis, we hypothesized that dietary n-6 polyunsaturated fatty acid (PUFA) may well decrease the incidence of this mode of cardiac cell death after diabetes. Male Wistar rats were first fed a diet rich in n-6 PUFA [20% (wt/wt) sunflower oil] for 4 wk followed by streptozotocin (STZ, 55 mg/kg) to induce diabetes. After a brief period of hyperglycemia (4 days), hearts were excised for functional, morphological, and biochemical analysis. In diabetic rats, n-6 PUFA decreased caspase-3 activity, crucial for myocardial apoptosis. However, cardiac necrosis, an alternative mode of cell death, increased. In these hearts, a rise in linoleic acid and depleted cardiac glutathione could explain this "switch" to necrotic cell death. Additionally, mitochondrial abnormalities, impaired substrate utilization, and enhanced triglyceride accumulation could have also contributed to a decline in cardiac function in these animals. Our study provides evidence that, in contrast to other models of diabetic cardiomyopathy that exhibit cardiac dysfunction only after chronic hyperglycemia, n-6 PUFA feeding coupled with only 4 days of diabetes precipitated metabolic and contractile abnormalities in the heart. Thus, although promoted as being beneficial, excess n-6 PUFA, with its predisposition to induce obesity, insulin resistance, and ultimately diabetes, could accelerate myocardial abnormalities in diabetic patients.

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Section: Discussionmentioning

confidence: 98%

Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA

Ghosh

Ding

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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“…After this plateau, a dose-response curve was again found, indicating that during the observation time no saturation of the AA pool and transport systems and hence no steady state were reached. Seyberth et al [53] observed an increase in 7c~-hydroxy-5,1 l-diketotetranorprostane-l, 16-dioic acid, the urinary metabolite of prostaglandin E, immediately after supplementation of the diet with 6 g/d ethylarachidonate, underlining the known stimulation of AA on eicosanoid production shown in cell cultures [1,59] and animal experiments [17,25,39]. The excretion of the prostaglandin E urinary metabolite showed no further increment during the time of AA supplementation.…”

Section: Effects Of Increased Uptake Of Arachidonic Acidmentioning

confidence: 98%

Immediate and long range effects of the uptake of increased amounts of arachidonic acid

Adam¹

1992

Clin Investig

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“…Indeed , in com pari son to Afr ica n schoolchildre n Eur opean ones do hav e markedly higher serum choles terol concentrations (33). In adults, higher cho lesterol concentration correlate s with the incidenc e of ischemic heart disease (34,35), and an inverse correlation bet wee n serum and tissue linoleate and the incidence of myocardia l .infarction have also been re ported (36)(37)(38)(39). Findings in Greenland E skimos suggest that high plasma long chain w-3-FA, as pre sent in the Nigeria n children, protects agai ns t cardiova scu la r disease (40 ,41).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Fatty Acid Composition of Plasma Lipid Fractions in Well‐Nourished Nigerian and German Infants and Toddlers

Koletzko,

Abiodun,

Laryea

et al. 1986

J. pediatr. gastroenterol. nutr.

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SummaryThe dietary intake of essential fatty acids is reflected by the plasma lipid composition. Only scanty data is available on the pattern of plasma fatty acids in young children and the influence of different environments. We analyzed the fatty acid composition of plasma sterolesters, triglycerides, and phospholipids in well‐nourished‐appearing children from Benin City, Nigeria (n = 8; aged 14.1 ± 7.2 months) and Düsseldorf, FRG (n = 17; aged 15.2 ± 5.1 months). The Nigerian group tended to have bigger proportions of the essential ‐6‐fatty acids, linoleic acid, and its metabolites, and by far higher values for long‐chain co‐3‐fatty acids, which are considered to be protective against atherogenesis. The saturated and nonessential monoenoic fatty acids tended to be lower in the Nigerian children, and the ratio of polyun‐saturated to saturated fatty acids was higher. We conclude that the quality of dietary fat in the German children was worse and may imply an increased risk for development of atherosclerosis.

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Serum linoleic acid and cardiovascular death in postinfarction middle-aged men

Cited by 26 publications

References 16 publications

Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA

Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA

Immediate and long range effects of the uptake of increased amounts of arachidonic acid

Comparison of Fatty Acid Composition of Plasma Lipid Fractions in Well‐Nourished Nigerian and German Infants and Toddlers

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