Serum lipid levels in benign prostatic hyperplasia

Abstract

The relationship between serum lipid levels and measures of benign prostatic hyperplasia was investigated. The study was community based. All the participants had undergone a urological investigation which included International Prostate Symptom Score (I-PSS) and Quality of Life Score (QoL), serum lipid concentrations and determination of prostate volume with transrectal ultrasonography. Body mass index was calculated with the formula of weight (kg)/surface area (m(2)) respectively. Men were considered obese if their body mass index was over 25 kg/m(2). BPH was defined by prostate volume greater than 20 ml and I-PSS greater than seven. Comparisons of serum lipid levels between men with BPH and without BPH were done. There was no correlation for serum lipid levels with either mean I-PSS and QoL scores. However, triglyceride and cholesterol levels were the lowest in severe symptomatic men than men with low symptoms. Using clinical definition of BPH that prostate volume was greater than 20 ml and I-PSS was greater than seven, men with BPH had not significantly different serum lipid levels from men without BPH. Our population-based data reflect that there was no relationship between serum lipid levels and certain physiological measures of lower urinary tract symptoms and clinical benign prostatic hyperplasia.

Body Mass Index and its Association with Genitourinary Disorders in Men Undergoing Prostate Cancer Screening

“…For example a cross‐sectional Austrian population‐based study (N = 939) reported no association between BMI and IPSS [50]. A Turkish study (N = 286) found no relationship between serum lipids and IPSS [51]. Finally, a large‐scale population‐based study (N = 2797) from the united States, demonstrated that current BMI is unrelated to LUTS or to the history of prostatic surgery for LUTS [32].…”

Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

“…Hammarsten et al found in a cohort of Swedish men with BPH that lower HDL cholesterol, higher LDL cholesterol, and higher triglycerides were associated with increased prostate volume (Hammarsten et al, 1998). While in a case control study, Indian men undergoing BPH surgery were more likely to have lower HDL and higher LDL cholesterol compared to controls (Nandeesha et al, 2006); there was no association of patient-reported hyperlipidemia with histological BPH in a case-control analysis on Italian men (Zucchtto et al, 2005) and no association of serum lipids or lipoproteins with International Prostate Symptom Score or prostate volume in a cohort of Turkish men (Lekili et al, 2006). Similarly, no association of serum lipids or lipoproteins was found with ICD-9 coded BPH diagnosis in a cohort of U.S. Air Force Veterans (Gupta et al, 2006).…”

Modifiable Risk Factors for Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms: New Approaches to Old Problems

“…17 However, in a cohort of community dwelling Turkish men there were no significant associations of serum lipids with BPH or LUTS. 21 Similarly in the case-control Hypertension. Lastly, formal criteria for metabolic syndrome also include hypertension.…”