Serum lipid levels in women with premature ovarian failure

Gülhan, İbrahim; Bozkaya, Giray; Uyar, İbrahim; Öztekin, Deniz; Pamuk, Barış Önder; Dogan, Erbil

doi:10.1097/gme.0b013e318254102b

Cited by 45 publications

(33 citation statements)

References 16 publications

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“…Earlier studies have described several changes in lipids among women with POI, as early as in their 30s, similar to the present findings in climacteric women at the age of 46: higher TC (29,35), higher HDL-C (29), higher LDL-C (35) and higher triglycerides (27). There is little research on the lipid profile of women with POI in their 50s, but Daan et al (28) found no difference in TC, LDL-C or triglyceride levels between women with POI and age-matched premenopausal controls, whereas they found HDL-C levels were higher in women with POI.…”

Section: Discussionsupporting

confidence: 92%

Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Savukoski

Mäkelä

Auvinen

et al. 2019

The Journal of Clinical Endocrinology &Amp; Metabolism

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at the modification stage), and do not reflect editorial changes. No corrections/changes to the PDF manuscripts are accepted. Accordingly, there likely will be differences between the Advance Article manuscripts and the final, typeset articles. The manuscripts remain listed on the Advance Article page until the final, typeset articles are posted. At that point, the manuscripts are removed from the Advance Article page. DISCLAIMER: These manuscripts are provided "as is" without warranty of any kind, either express or particular purpose, or non-infringement. Changes will be made to these manuscripts before publication. Review and/or use or reliance on these materials is at the discretion and risk of the reader/user. In no event shall the Endocrine Society be liable for damages of any kind arising references to, products or publications do not imply endorsement of that product or publication.

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Section: Discussionsupporting

confidence: 92%

Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Savukoski

Mäkelä

Auvinen

et al. 2019

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…11 A proinflammatory change in cytokine activity has been observed after menopausal transition 28 that can produce an unfavorable change in the vascular system, through endothelial dysfunction and change in aortic wall composition. 29 Estrogen deprivation is also associated with adverse changes in metabolic profile after menopause, through an increase in body weight and an atherogenic lipid profile, 30 and both of these alterations were observed in our experimental animals.…”

Section: Discussionmentioning

confidence: 82%

Supplementation of Omega-3 Polyunsaturated Fatty Acids Prevents Increase in Arterial Stiffness After Experimental Menopause

Losurdo

Grillo

Panizon

et al. 2013

J Cardiovasc Pharmacol Ther

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“…1,12 ; however, a recent study of women with ovarian failure and low estradiol concentrations also reported high total cholesterol and low-density lipoprotein cholesterol concentrations. 13 In the present study using percentiles of sex hormones generated in 10-year age groups and thus circumventing the age-dependent changes in sex hormones, we observed that low plasma concentrations of endogenous estradiol were associated with modest adverse effects on cardiovascular risk factors, and that high plasma concentrations of endogenous testosterone were associated with adverse effects on plasma total cholesterol, body mass index, plasma glucose, and blood pressure in women. This suggests that low estradiol is directly associated with cardiovascular risk, whereas the risk observed for high testosterone may be mediated through other cardiovascular risk factors.…”

Section: Arterioscler Thromb Vasc Biolmentioning

confidence: 82%

Extreme Concentrations of Endogenous Sex Hormones, Ischemic Heart Disease, and Death in Women

Benn

Voss

Holmegard

et al. 2015

ATVB

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Objective-Sex hormones may be critical determinants of ischemic heart disease and death in women, but results from previous studies are conflicting.To clarify this, we tested the hypothesis that extreme plasma concentrations of endogenous estradiol and testosterone are associated with risk of ischemic heart disease and death in women. Approach and Results-In a nested prospective cohort study, we measured plasma estradiol in 4600 and total testosterone in 4716 women not receiving oral contraceptives or hormonal replacement therapy from the 1981 to 1983 examination of the Copenhagen City Heart Study. During ≤30 years of follow-up, 1013 women developed ischemic heart disease and 2716 died. In women with a plasma estradiol below the fifth percentile compared with between the 10th and 89th percentiles, multifactorially adjusted risk of ischemic heart disease was 44% (95% confidence interval, 14%-81%) higher; however, plasma estradiol concentrations did not associate with death. Also, in women with a plasma testosterone concentration at or above the 95th percentile compared with between the 10th and 89th percentiles, multifactorially adjusted risk was 68% (34%-210%) higher for ischemic heart disease, 36% (18%-58%) higher for any death, and 38% (15%-65%) higher for death from other causes than cardiovascular disease and cancer. These results were similar for postmenopausal women alone. Conclusions-In women, extreme low concentrations of endogenous estradiol were associated with high risk of ischemic heart disease, and extreme high concentrations of endogenous testosterone were associated with high risk of ischemic heart disease and death. compared with younger women, percentiles of sex hormones were generated in 10-year age groups. Materials and MethodsMaterials and methods are available in the online-only Data Supplement. ResultsIn this nested cohort study, we included 4716 women from the 1981 to 1983 examination of the Copenhagen City Heart Study, which in total examined 12 698 individuals (7018 women and 5680 men) and is a prospective general population study, initiated in 1976 to 1978 with follow-up examinations in 1981 to 1983, 1991 to 1994, and 2001 to 2003. Among the 7018 women, plasma was available on 6023; however, as 247 women receiving oral contraceptives and 1060 receiving hormonal replacement therapy at baseline were excluded, plasma estradiol and testosterone measurements were available in 4600 and 4716 women for the present study. Baseline characteristics of these women are shown in the Table. Plasma Estradiol and TestosteroneFor plasma estradiol and testosterone concentrations, the median value was 445 pmol/L (interquartile range, 280-760; 95% confidence interval, 160-2170) in premenopausal and 150 pmol/L (120-180; 60-240) in postmenopausal women (Figure 1). For plasma testosterone concentrations, the corresponding values were 1.9 nmol/L (1.6-2.3; 1.1-3.1) in premenopausal and 1.9 nmol/L (1.5-2.3; 1.1-3.1) in postmenopausal women. Plasma estradiol and testosterone concentrations were relatively high in ...

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Serum lipid levels in women with premature ovarian failure

Abstract: Higher TC and LDL levels in women with POF compared with the control group suggest that estrogen deprivation in women with POF leads to unfavorable lipid changes.

Cited by 45 publications

References 16 publications

Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Supplementation of Omega-3 Polyunsaturated Fatty Acids Prevents Increase in Arterial Stiffness After Experimental Menopause

Extreme Concentrations of Endogenous Sex Hormones, Ischemic Heart Disease, and Death in Women

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