Serum Lipid Pattern in &lt;i&gt;β&lt;/i&gt;-Thalassaemia

Giardini, O; Murgia, Fabrizio; Martino, Francesco De; Mannarino, Olga; Corrado, Giovanni; Maggioni, G

doi:10.1159/000207703

Cited by 24 publications

(19 citation statements)

References 13 publications

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“…In the same study it was shown that the levels of serum lipid multiple unsaturated fatty acids decreased [21]. Those changes appear as a result of excessive iron-loading and liver damage [21]. Serum total cholesterol level has been found to be low, in accordance with the study we performed in patients with B-TM.…”

Section: Discussionsupporting

confidence: 76%

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Serum Lipid Values in Children with Beta Thalassemia Major

Arıca¹

2012

Pediat Therapeut

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Objective: The purpose of the study was to examine the blood lipid profile in children with beta-Thalassemia major, and to determine the factors that affect it.Material and Method: Files of eighty-five patients between the ages of five and fifteen with beta-Thalassemia major who were receiving regular chelation therapy followed by from paediatric policlinic of our hospital were examined retrospectively. Blood lipid profiles of fifty-five healthy children were taken for use as the control group. A total of 117 children were enrolled and examined in the study. Findings:Hb and Hct values of the group with Beta-Thalassemia major were significantly lower than the control group (p<0.005). Ferritin values in the group with Beta-Thalassemia major were found to be significantly higher than in the control group (p<0.005). Cholesterol, HDL-cholesterol, LDL-cholesterol levels were found to be significantly lower in patients with Beta-Thalassemia major than in the control group (p<0.001), while the triglyceride level was found to be higher (p<0.001). Result:We determined a positive correlation between triglyceride and serum ferritin levels. It may indicate excessive iron loading, and changes in blood lipid values in patients with Beta-Thalassemia major.

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Section: Discussionsupporting

confidence: 76%

“…A study demonstrated that total phospholipids and its functions also decrease with the decrease of total cholesterol [21]. In the same study it was shown that the levels of serum lipid multiple unsaturated fatty acids decreased [21]. Those changes appear as a result of excessive iron-loading and liver damage [21].…”

Section: Discussionmentioning

confidence: 96%

Serum Lipid Values in Children with Beta Thalassemia Major

Arıca¹

2012

Pediat Therapeut

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“…LDL/HDL ratios increase from controls < non-transfused < transfused < long-term transfused patients. Abnormal serum lipid and lipoprotein patterns had been reported in thalassemia patients [8,17]. However, in this context, not only lipid metabolism must be considered, but also the effect of generally decreased cholesterol levels on biosynthesis of steroids in these patients.…”

Section: Discussionmentioning

confidence: 99%

Iron status and oxidative stress in β‐thalassemia patients in Jakarta

Laksmitawati

Handayani

Udyaningsih-Freisleben

et al. 2003

BioFactors

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Abstract.A study on thalassemia intermedia and major patients in Jakarta was initiated to obtain a comprehensive picture of metabolic dysregulation, iron overload, oxidative stress, and cell damage. Data are presented from a group of 14 transfusiondependent patients in an age range of 11-25 years (T) and another group of 9 frequently transfused (for at least 15 years) patients aged 17-30 years (L). A third group comprised 6 patients (aged 7 to 14 years) who had not yet obtained transfusions (N). The 21 controls (C) were voluntary students without diagnosis or clinical signs of thalassemia up to 30 years of age. The study was approved by the Ethical Clearance Board of the Medical Faculty and all blood samples from controls and patients were obtained on fully informed consent. Levels of antioxidants (vitamins A, C, E and β-carotene) and reactive thiols are considerably decreased in transfused patients, whereas signs of iron overload and cell damage are increased (serum iron, ferritin, transferrin saturation, SGOT, SGPT, γ-GT, bilirubin). Results can be summarized that non-transfused thalassemia intermedia patients exert slight signs of oxidative stress, and increased hemoglobin degradation but no significant indication of tissue or cell damage. This picture differs considerably from transfusion-dependent thalassemia major patients: highly significant decrease in antioxidants and thiols and tremendous iron overload and cell damage. The picture is even worsened in long-term transfused patients. Iron chelation after transfusion is not sufficient in Indonesia, because it is normally (with few exceptions) applied only once together with transfusion. Hence, one major reason of the bad condition of transfusion-dependent thalassemia patients in Indonesia appears to be frequent transfusions (on the average one per month) and insufficient chelation of one treatment per month together with transfusion.

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“…20 In our study, we found MDA levels (nmol/mL) to be significantly increased in b thalassemia patients as compared to controls. Giardini et al 21 demonstrated that red blood cell MDA was significantly higher in b thalassemia patients as compared to controls. Livrea 8 showed that the mean concentrations of lipoperoxides evaluated as malondialdehyde/thiobarbituric acid (MDA/TBA) adducts, increased about twofold in their thalassemic patients with respect to controls.…”

Section: Articlementioning

confidence: 99%

Carotid Intima-Media Thickness and Oxidative Stress Markers for Assessment of Atherosclerosis in Children with β Thalassemia Major

Jindal

Chavan

Kaur

et al. 2016

Thalassemia Reports

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The present study evaluates carotid intimamedia thickness (CIMT) in children with b thalassemia major to assess atherosclerosis and its relation to the underlying proposed causative mechanisms via lipid peroxidation product malondialdehyde (MDA), oxidized lowdensity lipoproteins (LDL), total antioxidant level, and lipid profile. A cross sectional study was conducted on 62 children (31 cases and 31 controls). CIMT by high resolution ultrasound and biochemical parameters i.e., total cholesterol, triglycerides, high-density lipoproteins, LDL, Oxidized LDL, lipoprotein (a), lipid peroxidation product MDA and total antioxidant were measured in enrolled subjects and compared. In our study, CIMT was significantly increased in b thalassemia major patients' as compared to healthy controls. Mean CIMT in cases was 0.69±0.11 mm and in controls 0.51±0.07 mm. Mean oxidized LDL (EU/mL) in cases 39.3±34.4 (range 14.4 to 160) was significantly raised (P=0.02, t test) as compared to controls 23.9±13.4 (range 12 to 70). In our study we found MDA levels (nmol/mL) to be increased in b thalassemia patients as compared to controls. Mean MDA was 10.0±3.27 (4.41 to 17.48) in cases while in controls was 6.87±4.55 (1.5 to 17.9). Our study results show CIMT as an early marker of atherogenesis in b thalassemia major. Oxidative stress markers are also increased in b thalassemia major patients and lipoprotein (a) shows a positive correlation with CIMT. The present study points towards various atherogenetic mechanisms in b thalassemia major.

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Serum Lipid Pattern in <i>β</i>-Thalassaemia

Cited by 24 publications

References 13 publications

Serum Lipid Values in Children with Beta Thalassemia Major

Serum Lipid Values in Children with Beta Thalassemia Major

Iron status and oxidative stress in β‐thalassemia patients in Jakarta

Carotid Intima-Media Thickness and Oxidative Stress Markers for Assessment of Atherosclerosis in Children with β Thalassemia Major

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