Serum lipid profile in oral squamous cell carcinoma: alterations and association with some clinicopathological parameters and tobacco use

Acharya, Swetha; Rai, Pragati; Hallikeri, Kaverı; Anehosur, Venkatesh; Kale, Jyoti

doi:10.1016/j.ijom.2016.01.015

Cited by 26 publications

(21 citation statements)

References 23 publications

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“…This was in accordance with the study conducted by Acharya et al .,[19] Garg et al .,[10] Li et al .,[9] Lohe et al .,[12] Kumar et al ., Ghosh et al .,[20] and Patel et al . [21] Lower lipid profile levels have been associated in a variety of cancers ranging from head and neck to pancreatic cancers.…”

Section: Discussionsupporting

confidence: 93%

Analysis of lipid profile in cancer patients, smokers, and nonsmokers

et al. 2016

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Background:Lipids play an important role in maintaining the cell membrane integrity. Lipid profile is a panel of blood tests that serve as an initial medical screening for abnormalities in lipids and approximate risk for cancer, cardiovascular diseases, pancreatitis, etc., The present study evaluates the alterations in lipid profile in cancer patients, smokers, and nonsmokers and aims to achieve a correlation between them.Materials and Methods:The study is an in vitro type of cross-sectional study with 25 oral cancer patients, 25 chronic smokers (habit persisting for 15 years or more), and 15 nonsmokers as control group. Blood samples had been collected, and triglycerides (TGs), total cholesterol (TC), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) were analyzed using a lipid profile kit and an autoanalyzer. The results were analyzed using the unpaired t-test and ANOVA test (P < 0.05).Results:There was a significant increase in TC, TG, LDL, and VLDL and decrease in HDL in the smokers group when compared to the controls (P < 0.05). A significant increase in LDL, but a decrease in values of HDL, VLDL, TG, and TC was observed in the cancer patients group when compared to the controls (P < 0.05).Conclusion:There is an inverse relationship between serum lipid profile in smokers and cancer patients. The decrease in lipid profile in cancer patients might be due to their increased utilization of lipids by neoplastic cells in membrane biogenesis. Therefore, a decrease in lipid profile in smokers can be assumed that they might be more prone to develop cancerous conditions.

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Section: Discussionsupporting

confidence: 93%

Analysis of lipid profile in cancer patients, smokers, and nonsmokers

et al. 2016

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“…1,8 Acharya et al reported significant decrease in TC, HDL, LDL, and VLDL but not for TG in patients with OSCC. 3 Nydegger et al observed a decrease in α -lipoprotein and cholesterol levels and was possibly due to increased catabolism of αlipoprotein and cholesterol, decreased synthesis of α-lipoprotein and cholesterol by liver as the synthesis is affected by tumor metabolites. 39 In neoplastic tissue, an increased level of low density lipoprotein activity in tumor cells may produce hypocholesteremia.…”

Section: Discussionmentioning

confidence: 99%

Correlation of plasma lipid levels and histopathological grading in patients with oral squamous cell carcinoma and its pre-cancerous lesions

Singh

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Lower levels of lipid in proliferating tissues and in blood compartments may occur due to ongoing process of oncogenesis. The evidence regarding hypolipidemia as a predisposing factor for malignancy is scarce. Therefore, this study was undertaken to study alteration of plasma lipid levels in patients diagnosed with oral squamous cell carcinoma (OSCC) and its oral pre-cancerous (OPC) lesions and also to compare the plasma lipid profile in different grades of OSCC.Methods: A single centre prospective cross sectional study was carried out among 150 consecutive patients of OSCC and OPC lesions. The diagnosis of all lesions was confirmed histopathologically and grading was also done for each lesion based on degree of differentiation and keratinization of tumour cells. Serum total cholesterol, HDL, TG, LDL was estimated by using semi-automated chemical analyzer. The lipid levels were compared by using unpaired t-test between two strata whereas one way analysis of variance (ANOVA) with Tukey’s post-hoc tests was used among more than two strata. Results: Total cholesterol, TG, HDL, and LDL were significantly reduced in OSCC and OPC groups when compared with the reference values. Serum TC, LDL and HDL levels were found to be decreased with the loss of differentiation in histological grading but with no statistical significance.Conclusions: It can be inferred that there is an inverse relationship between the serum lipid profile values of TC, HDLC, TG, LDL and OSCC as well as OPC patients. The lower serum lipid status may be considered a useful indicator for initial changes occurring in neoplastic cells.

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“…The squamous cell carcinoma is a neoplasm related, mainly, to tobacco and alcohol abuse (KAMINAGAKURA et al, 2016). Acharya et al (2016) stated that carcinoma is the eight most common malign neoplasm in the World. According to Loganathan et al (2017), tongue malignancies account for 90% of carcinomas in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

The Use of the Papanicolaou Stain to Routine Histological Examination: Teaching the Basic Microscopy of Squamous Cell Carcinoma

Mainenti¹

2018

Rev Int Est Exp

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Introduction: The understanding of microscopy classes is imperative to the student in human pathology. Objective: To prepare the student to observe and understand, through tinctorial recognition, the main histologic features of Papanicolaou-stained well-differentiated carcinomas. Methods: A selected case of a well-differentiated carcinoma of the tongue was used for a Papanicolaou stain. Results: The Papanicolaou-stained slides showed, basically, basal cells in a faint to a dark blue color. The stratum spinosum stained light pink to a faint blue-green and the keratin layer and the keratin pearls stained bright orange. The connective tissue stained light green. Conclusion: The use of Papanicolaou stain was found very convenient as the beginner in histopathology can perform a ready identification of the well-differentiated squamous cell carcinoma aspects.

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Serum lipid profile in oral squamous cell carcinoma: alterations and association with some clinicopathological parameters and tobacco use

Cited by 26 publications

References 23 publications

Analysis of lipid profile in cancer patients, smokers, and nonsmokers

Analysis of lipid profile in cancer patients, smokers, and nonsmokers

Correlation of plasma lipid levels and histopathological grading in patients with oral squamous cell carcinoma and its pre-cancerous lesions

The Use of the Papanicolaou Stain to Routine Histological Examination: Teaching the Basic Microscopy of Squamous Cell Carcinoma

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