Serum Lipids and Polysaccharides in Diabetes Mellitus

Adlersberg, David; Wang, Chun-I; Rifkin, Harold; Berkman, James I.; Ross, George; Weinstein, Curt

doi:10.2337/diab.5.2.116

Cited by 38 publications

(9 citation statements)

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“…It is more probable that the increased levels of the different plasma lipid fractions play an important role. The largest percentage increase was found for the triglycerides, which is in accordance with earlier findings (6). The dietary management of diabetes must be directed toward a normalization not only of the blood sugar level but also of the blood lipid level.…”

Section: Discussionsupporting

confidence: 76%

“…Even in well controlled diabetic patients an elevation of the serum lipids is often seen when the diabetes has lasted for some years. Adlersberg and co-workers (6) reported that diabetic patients with vascular complications had significantly higher serum lipid levels than did cases with uncomplicated diabetes or normal controls. Lowy and Barach (7) found that this augmentation of the lipids preceded the symptoms of vascular complications.…”

mentioning

confidence: 99%

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Gas Chromatographic Analysis of the Fatty Acid Composition of the Plasma Lipids in Normal and Diabetic Subjects*

Hallgren¹,

Stenhagen²,

Svanborg³

et al. 1960

J. Clin. Invest.

152

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Section: Discussionsupporting

confidence: 76%

mentioning

confidence: 99%

Gas Chromatographic Analysis of the Fatty Acid Composition of the Plasma Lipids in Normal and Diabetic Subjects*

Hallgren¹,

Stenhagen²,

Svanborg³

et al. 1960

J. Clin. Invest.

152

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“…We were surprised to note such a strong association of this variable, which was measured only once annually, and had been demonstrated to be related only to more advanced stages of retinopathy by means of the individual life-table analysis. In a number of previous reports [19,[24][25][26][27][28], conflicting results were found of the effects of triglyceride levels on retinopathy. Possibly they act via the influence of plasma lipids on red cell aggregation [29].…”

Section: Discussionmentioning

confidence: 95%

Risk factors for the development of retinopathy in children and adolescents with Type 1 (insulin-dependent) diabetes mellitus

Weber¹,

Burger²,

Hartmann³

et al. 1986

Diabetologia

114

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In our preceding paper, the prevalence and development of retinopathy in 231 Type 1 diabetic children and adolescents were reported to be associated with the duration of diabetes and its age at onset. This paper analyses the relationships between the development of retinopathy and the following factors: age, sex, puberty, blood pressure, insulin dosage, HLA antigens, long-term glycaemic control, and serum cholesterol and triglycerides. All these variables were longitudinally evaluated in a cohort of 322 insulin-dependent patients aged 16.2 +/- 4.9 years with diabetes for 7.4 +/- 5.2 years, including those 231 subjects whose eyes were examined once or repeatedly by ophthalmoscopy and fluorescein angiography. Long-term glycaemic control from the onset of diabetes to the retinal examination was assessed by both an arbitrary score comprising different parameters and by mean values of glycosylated haemoglobin, and was categorised as good, fair, and poor. With life-table analysis, the overall median individual risk for developing early retinal changes (9.1 years) was found to be significantly influenced by glycaemic control. Minimal lesions developed earlier (8.0 years) with poor control, but later with fair (10.5 years) and good glycaemic control (12.5 years) (p less than 0.01). Mean HbA1 values below 10% delayed the onset of both incipient (10.8 years) and background retinopathy (16.6 years), while values above 10% advanced it (8.0 and 11.8 years respectively) (p less than 0.05 and less than 0.008). By multivariate regression and stepwise discrimination analyses, only 4 out of 14 variables were found to exert significant independent influences on the development of retinopathy: diabetes duration, long-term glycaemic control, serum triglycerides and age.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…syndrome. Thus, Berkman et al (1953Berkman et al ( , 1954, in a study of the serum polysaccharides in diabetics and non-diabetics, reported an increase in the total serum polysaccharides in diabetics with degenerative vascular complications, the highest level being observed in those with clinically evident nephropathy (Adlersberg et al, 1956). It is not clear whether this increase is due to the renal impairment and is thus the result of the diabetic nephropathy, or whether it precedes the nephropathy and provokes the pathological lesions in the kidneys.…”

mentioning

confidence: 99%