Serum Lipids in Infection

Gallin, John I.; Kaye, Donald; O’Leary, William M.

doi:10.1056/nejm196911132812001

Cited by 355 publications

(135 citation statements)

References 22 publications

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“…Inflammatory conditions under bacterial or viral infections were found to result in an increase in the serum concentration of triglycerides and a decrease in the serum HDL-cholesterol in humans (17,18). Multiple cytokines are likely to affect the metabolism of cholesterol or triglycerides through several pathways, including the increased production and decreased clearance of very low-density lipoproteins, impaired reverse cholesterol transport and decreased excretion of bile acids (16,(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Fujimaki

Kato

Oguri³

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. We previously identified rs6929846 of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) as a susceptibility locus for myocardial infarction in Japanese individuals by a genome-wide association study. The aim of the present study was to examine the relation of the rs6929846 polymorphism of BTN2A1 to dyslipidemia in Japanese and Korean populations, given that dyslipidemia is an important risk factor for myocardial infarction. A total of 10,953 individuals from three independent subject panels were examined. The relations of the rs6929846 polymorphism of BTN2A1 to serum concentrations of triglycerides, high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol were examined in each subject panel. The C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with serum concentrations of triglycerides in Japanese subject panels A (P=0.0004) and B (P=0.0010), and in the Korean population (P=0.0095), with the minor T allele being related to an increased serum concentration of triglycerides. The rs6929846 was associated with serum concentrations of HDL-cholesterol in Japanese subject panels A (P=0.0047) and B (P=0.0015), with the T allele being related to a decreased serum concentration of HDL-cholesterol, but not in the Korean population. This polymorphism was associated with the serum concentration of LDL-cholesterol only in Japanese subject panel B (P=0.0059), with the T allele being related to an increased serum concentration of LDL-cholesterol. The results suggest that BTN2A1 may be a susceptibility gene for hypertriglyceridemia in East Asian populations and for low serum HDL-cholesterol in the Japanese population.

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Section: Discussionmentioning

confidence: 99%

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Fujimaki

Kato

Oguri³

et al. 2011

Experimental and Therapeutic Medicine

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“…6 Both cholesterol and triglyceride metabolism are affected by inflammatory pathways. 7,8 Reductions in cholesterol during acute inflammation may be a result of decreased hepatic production of lipoproteins or increased catabolism with conversion to small dense particles.…”

Section: See P 126mentioning

confidence: 99%

“…9,10 Increased triglyceride levels as a result of increased synthesis and secretion is a more consistent feature of inflammationinduced lipid changes. 6,11 These observations raise the possibility that the impact of diet on plasma lipids could be modified by the degree of underlying inflammation.…”

Section: See P 126mentioning

confidence: 99%

Inflammation Modifies the Effects of a Reduced-Fat Low-Cholesterol Diet on Lipids

et al. 2003

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Background-Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet. Methods and Results-After a 2-week run-in period on a control diet (37% total fat, 16% saturated fat), 100 participants were randomized to the control or DASH diet (27% total fat, 6% saturated fat) for 12 weeks. Median C-reactive protein (CRP) at baseline was 2.37 mg/L (interquartile range, 1.20, 3.79). The DASH diet, net of control, had no effect on CRP. Overall, there were significant net reductions in total (Ϫ0.34 mmol/L), LDL (Ϫ0.29 mmol/L), and HDL (Ϫ0.12 mmol/L) cholesterol from the DASH diet (each, PϽ0.001) and little change in triglycerides (ϩ0.05 mmol/L, Pϭ0.21). Baseline CRP was strongly associated with lipid responsiveness to the DASH diet. Total and LDL cholesterol were reduced to a greater degree in those with a "low" (below median) compared with a "high" (above median) baseline CRP (total, Ϫ9.8% versus Ϫ3%; P for interactionϭ0.006; LDL cholesterol, Ϫ11.8% versus Ϫ3%; P for interactionϭ0.009). Reductions in HDL cholesterol (Ϫ8.8%) were similar in persons with low versus high CRP. Triglycerides were increased in those with a high CRP but not in those with a low CRP (19.8% versus ϩ0%; P for interactionϭ0.019). Conclusions-In this study, the presence of increased CRP was associated with less total and LDL cholesterol reduction and a greater increase in triglycerides from a reduced-fat/low-cholesterol diet. These findings document an additional mechanism by which inflammation might increase cardiovascular disease risk.

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“…Inflammation is a key component of regulating lipid metabolism, and it leads to changes in lipid metabolism aimed at decreasing the toxicity of a variety of harmful agents and tissue repair by redistributing nutrients to cells involved in the host defense (17,18). An inflammatory condition under bacterial or viral infection has been shown to result in an increase in the serum concentration of triglycerides and a decrease in the serum HDL-cholesterol (19,20). Multiple cytokines are likely to affect the metabolism of cholesterol or triglycerides through several pathways, including the increased production and decreased clearance of extremely low density lipoproteins, impaired reverse cholesterol transport and decreased excretion of bile acids (17,(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals

Horibe

Ueyama

Fujimaki

et al. 2014

Molecular Medicine Reports

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Abstract.We have previously shown that the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction. Considering that dyslipidemia is a significant risk factor for coronary heart disease, it was hypothesized that the association between rs6929846 of BTN2A1 and myocardial infarction may be attributable, at least in part, to its effect on the susceptibility to dyslipidemia. The purpose of the present study was to examine a possible association of rs6929846 of BTN2A1 with dyslipidemia in community-dwelling individuals. The study subjects were comprised of 5,958 community-dwelling individuals (2,909 subjects with dyslipidemia and 3,049 controls) who were recruited into a population-based cohort study in Inabe, Japan. Dyslipidemia was defined by a serum concentration of triglycerides of ≥1.65 mmol/l, a serum high-density lipoprotein-cholesterol concentration of <1.04 mmol/l or a serum low-density lipoprotein (LDL)-cholesterol concentration of ≥3.64 mmol/l. A comparison of the allele frequencies or genotype distributions by the χ 2 test revealed that rs6929846 of BTN2A1 was significantly associated with dyslipidemia (P<0.05). A multivariable logistic regression analysis adjusted for age, gender, body mass index, smoking status and the prevalence of diabetes mellitus revealed that rs6929846 of BTN2A1 was significantly (dominant model; P=2.4x10 -4 ; odds ratio, 1.29) associated with dyslipidemia, with the minor T allele representing a risk for this condition. Among all the individuals, the serum concentrations of total cholesterol, triglycerides and LDL-cholesterol were significantly greater for individuals in the combined CT and TT genotype groups than for those with the CC genotype. BTN2A1 may thus be a susceptibility gene for dyslipidemia in community-dwelling individuals.

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Serum Lipids in Infection

Cited by 355 publications

References 22 publications

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Inflammation Modifies the Effects of a Reduced-Fat Low-Cholesterol Diet on Lipids

Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals

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