Serum lipids, serum insulin, plasma fibrinogen and aerobic capacity in obese and non-obese Singaporean boys

Abstract

OBJECTIVES:To compare blood lipids, lipoproteins, apoproteins, ®brinogen, insulin and aerobic capacity in obese and nonobese Chinese Singaporean boys. To examine relationships between blood metabolites, body composition and aerobic capacity in these groups. DESIGN: Cross-sectional SUBJECTS: Forty Chinese Singaporean boys aged 13 ± 15 y. Classi®ed as obese (n 20) or non-obese (n 20) based on adiposity (fat massafat free mass): b 0.60 obese,`0.40 non-obese. MEASUREMENTS: Body composition (dual energy X-ray absorptiometry), waist circumference, peak oxygen consumption (VO 2 peak), serum concentrations of total cholesterol, triacylglycerol, high density lipoprotein cholesterol (HDL-C), total cholesterolaHDL-C, apoproteins AI and B, lipoprotein(a), insulin and glucose. Plasma concentration of ®brinogen. RESULTS: Obese boys had signi®cantly (P`0.01) higher (mean AE s.d.) concentrations of serum triacylglycerol (1.51 AE 0.65 vs 1.04 AE 0.34 mmolal), serum insulin (24.1 AE 11.5 vs 12.3 AE 4.45 mUal) and plasma ®brinogen (4.01 AE 0.54 vs 3.35 AE 0.76 gal) than non-obese boys. Within the non-obese group plasma ®brinogen concentration was signi®cantly related to percentage body fat (r 0.546, P`0.05). VO 2 peak relative to body mass (mlakgamin or mlakg 70.67 amin) was signi®cantly (P`0.001) lower in obese compared to non-obese boys but absolute VO 2 peak (lamin), adjusted for fat-free mass via analysis of covariance, was higher in obese than non-obese boys (P`0.01). Partial correlations revealed that none of the blood metabolites were signi®cantly related to VO 2 peak independent of body fatness. CONCLUSIONS: Obesity was related to elevated concentrations of serum triacylglycerol, serum insulin and plasma ®brinogen in Chinese Singaporean boys. These elevated concentrations did not appear to be associated with a lower aerobic capacity (independent of body fatness) in the obese. International Journal of Obesity (2001) 25, 984 ± 989

Health Consequences of Childhood Obesity

“…These Bengali obese children hence have every possibility of developing type 2 diabetes in near future. It is supported firmly by similar results from a number of previous studies abroad by Garcés et al [13], Stencel et al [14], Shea et al [16] and in north India by Misra et al [17]. The prevalence of hyperinsulinemia is higher in the present study compared to the study in UK children [12] (61% vs. 40%, p<0.05).…”

“…The previous studies have shown correlation of high BMI with high TG and low HDL only [13,14]. But in the present study a high significant correlation has been found between BMI and each of CH, LDL, TG and HDL, as well as between each of the lipid fractions indicating the risk of obesity induced dyslipidemia.…”

“…et al (2005) [13] among Spanish school children, Stencel et al (2001)[14] on Singaporean school children andHorri, Vakili (2006) …”

Overfatness, stunting and physical inactivity are determinants of plasminogen activator inhibitor-1activity, fibrinogen and thrombin–antithrombin complex in African adolescents

“…When adjusting for physical activity the significant difference in fibrinogen between the sexes remained, but adjustment for body fat percentage resulted in an insignificant difference in fibrinogen, indicating that the sex difference observed may be attributed to the girls having a significantly higher body fat percentage than the boys. Literature shows that plasma fibrinogen concentration is positively associated with anthropometric markers for body fat in boys and girls [19,49]. Halle et al [50] found significantly higher concentrations of the inflammatory parameters such as fibrinogen, interleukin-6 and tumour necrosis factoralpha in obese children when compared with nonobese children.…”

Indices of insulin resistance in paediatric obesity

“…26 A research in Singaporean adults has revealed a relationship between BMI, abdominal diameter and insulin resistance. 26,27 It has been reported that in children and adolescents the measurement of fasting insulin levels in the presence of normoglycaemia may be an indicator of IR, which is as good as HOMA-IR, FGIR and QUICKI. 22 However the variability of insulin measurements between laboratories makes it difficult in comparing the insulin levels obtained from different studies.…”