Serum Lysozyme in Crohn’s Disease and Ulcerative Colitis

The serum levels of lysozyme, serum electrophoresis, and serum immunoglobulins were determined prospectively in 101 patients with ulcerative colitis, ulcerative proctitis, Crohn's disease, or nonclassifiable nonspecific inflammatory bowel disease. Although the mean serum lysozyme concentration of patients with Crohn's disease (10.5 +/- 6.8 microgram/ml) and ulcerative colitis (9.6 +/- 4.1 microgram/ml) performed by a standardized lysoplate method was significantly greater than normal controls (6.0 +/- 1.5 microgram/ml), the results did not correlate with the diagnosis nor with the degree of disease activity. Individually separated protein fractions and serum immunoglobulins also did not correlate with the serum lysozyme levels. This study indicates that measurement of the level of serum lysozyme in individual patients is not helpful in determining the cause or degree of activity of nonspecific inflammatory bowel disease.

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Serum lysozyme, serum proteins, and immunoglobulin determinations in nonspecific inflammatory bowel disease

el-Khatib

Lebwohl

Attia

et al. 1978

Digest Dis Sci

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The estimation of serum lysozyme: A comparison of four assay methods

Klass

Hopkins

Neale

et al. 1977

Biochemical Medicine

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Melkersson-Rosenthal syndrome and crohn's disease

Worsaae

Christensen

Bondesen

et al. 1980

British Journal of Oral Surgery

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Serum Lysozyme in Crohn’s Disease and Ulcerative Colitis

Cited by 15 publications

References 9 publications

Serum lysozyme, serum proteins, and immunoglobulin determinations in nonspecific inflammatory bowel disease

Serum lysozyme, serum proteins, and immunoglobulin determinations in nonspecific inflammatory bowel disease

The estimation of serum lysozyme: A comparison of four assay methods

Melkersson-Rosenthal syndrome and crohn's disease

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