Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?

Brown, David A.; Hance, Kenneth W.; Rogers, Connie J.; Sansbury, Leah B.; Albert, Paul S.; Murphy, Gwen; Laiyemo, Adeyinka O.; Wang, Zhuoqiao; Cross, Amanda J.; Schatzkin, Arthur; Danta, Mark; Srasuebkul, Preeyaporn; Amin, Janaki; Law, Matthew; Breit, Samuel N.; Lanza, Elaine

doi:10.1158/1055-9965.epi-11-0786

Cited by 56 publications

(55 citation statements)

References 35 publications

(41 reference statements)

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“…Human GDF-15 expression is controlled by p53, which is linked to atherosclerosis and cancer (Yang et al, 2003). It has been shown that GDF-15 level is elevated in several cancers, including prostate, ovarian, pancreatic, and colorectal cancers and multiple myeloma (Staff et al, 2010;Breit et al, 2011;Wallin et al, 2011;Brown et al, , 2009Brown et al, , 2012Corre et al, 2012). In some cancer types, elevated levels of GDF-15 have been associated with adverse prognosis (Brown et al, 2009;Staff et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma

2016

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ABSTRACT. Tremendous efforts have been made in renal cell carcinoma (RCC) patients' research; however, clinical findings in patients have been disappointing. The aims of our study were to identify better or alternative therapeutic methods that can reverse chemotherapy resistance and to enhance sensitivity to docetaxel (DOX)-based chemotherapy drugs. We evaluated the anti-proliferative effect of DOX against RCC cells. DOX was found to suppress proliferation of RCC cells under in vitro and in vivo settings. Flow cytometric analysis revealed that DOX suppressed cell growth by induction of both apoptosis and G2/M cell cycle arrest in a dosedependent manner. Various patterns of gene expression were observed by cluster analysis. In addition, based on network analysis using the ingenuity pathway analysis software, DOX was found to suppress phosphorylation of extracellular signal-regulated kinase 1/2 and p38, suggesting that the mitogen-activated protein kinase signaling pathway plays a vital role in the anti-proliferative effect of DOX against RCC.

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Section: Discussionmentioning

confidence: 99%

Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma

2016

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“…Whereas reports thus far have investigated mainly regulation of MIC-1 at a transcriptional level, here we have uncovered a novel post-transcriptional mechanism by which MIC-1 expression can be regulated. Due to its high levels within certain cancers such as gastric, colorectal, prostate, ovarian, and breast cancer and its close association with the presence particularly of premalignant colonic diseases, MIC-1 is being explored as a marker of tumor progression and a prognostic serum biomarker (10,33,34). However, our understanding of the signaling pathways involving MIC-1 within the context of tumor development is still incomplete.…”

Section: Discussionmentioning

confidence: 99%

RNPC1, an RNA-binding Protein and a p53 Target, Regulates Macrophage Inhibitory Cytokine-1 (MIC-1) Expression through mRNA Stability

Yin

Cho

Chen

2013

Journal of Biological Chemistry

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“…However, this analysis was limited by the large variation in the time of MIC-1 measurement with respect to colonoscopy, which compromises its ability to determine whether MIC-1 elevation was a predisposing factor or consequence of colorectal adenoma. (40) For IL-6 and TNF-α, the only available study did not find any association with risk of recurrent adenomas. (38)…”

Section: Introductionmentioning

confidence: 98%

Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women

Song

Mehta

et al. 2016

Cancer Prevention Research

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Evidence remains inconclusive about the association of systemic inflammatory markers with colorectal neoplasia. We investigated whether circulating inflammatory markers were associated with risk of advanced colorectal adenoma. We measured plasma macrophage inhibitory cytokine-1 (MIC-1), C-reactive protein (CRP), interleukin-6 (IL-6), and soluble tumor necrosis factor receptor 2 (sTNFR-2) in blood samples drawn from 32,826 women in 1989-1990 in the Nurses' Health Study. Through 2008, we documented 757 cases of advanced colorectal adenomas (≥1cm or any size with advanced histology); each case was matched by age and time of blood draw with one control randomly selected from participants who underwent lower endoscopy and did not have neoplasia. Plasma MIC-1 was associated with higher risk of advanced adenoma (Ptrend=0.04), with an odds ratio of 1.55 (95% CI, 1.03-2.32) comparing extreme quintiles of MIC-1 after adjusting for colorectal cancer-risk factors and other inflammatory markers. Among cases, MIC-1 level was positively associated with the number of adenomas (P<0.001) and gradually increased from adenomas located in the rectum, distal colon, and up to the proximal colon. There was a strong positive association between MIC-1 and risk of adenomas with multiplicity, ≥1cm size and location in the proximal colon (all Ptrend<0.05). CRP, IL-6 or sTNFR-2 was not associated with adenoma risk. In conclusion, plasma MIC-1 was associated with higher risk of colorectal adenoma, especially multiple, large and proximal adenomas. Our results provide further support for a role for MIC-1 in carcinogenesis and the potential for MIC-1 as an adjunctive biomarker for detection of advanced colorectal adenoma.

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Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?

Cited by 56 publications

References 35 publications

Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma

Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma

RNPC1, an RNA-binding Protein and a p53 Target, Regulates Macrophage Inhibitory Cytokine-1 (MIC-1) Expression through mRNA Stability

Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women

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