Serum macrophage migration‐inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer

Abstract

Ethylene‐propylene‐diene terpolymers (EPDM) are generally amorphous and, therefore, do not crystallize from solution. Consequently, fractionation techniques based on crystallization, such as crystallization analysis fractionation or temperature rising elution fractionation, cannot be used to analyze their chemical composition distribution. Moreover, no suitable chromatographic system was known, which would enable to separate them according to their chemical composition. In this study, two different sorbent/solvent systems are tested with regard to the capability to separate EPDM‐terpolymers and ethylene‐propylene (EP)‐copolymers according to chemical composition. While porous graphite/1‐decanol system is selective towards ethylene and ethylidene‐2‐norbornene, carbon coated zirconia/2‐ethyl‐1‐hexanol is preferentially selective towards ethylene. Consequently, the earlier system enables to separate both EP copolymers and EPDM according to the chemical composition and the latter mainly according to the ethylene content. The results prove that the chromatographic separation in both sorbent/solvent systems is not influenced by molar mass of a sample or by its long chain branching. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets

“…A similar observation was reported in colorectal cancer, where serum MIF levels were elevated in patients with hepatic or lymphoid metastasis when compared with those without metastasis (11). Furthermore, gastric cancer patients with a serum MIF level of ≥6,600 pg/ml exhibited a poorer prognosis than those with lower serum MIF levels (33).…”

Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients

“…Moreover, MIF inhibits the recruitment of cancer-associated fibroblasts to growing tumors in an CXCR2/ CD74-dependent manner; therefore, therapeutic inhibition of MIF in rhabdomyosarcoma may accelerate metastasis and tumor growth (50). In drug-resistant human colon cancers, the MIF-CXCR4 axis mediates the invasive and metastatic phenotype of the cancer (53,54), but MIF does not play a prominent role in tumor progression in gastric adenocarcinomas (55). Collectively, these findings indicate that MIF has multiple functions in tumor microenvironments.…”

Cloning and mRNA expression of macrophage migration inhibitory factor (MIF) gene of large yellow croaker (Pseudosciaena crocea)

“…Furthermore, human MIF is a good molecular biomarker which has been clinically applied in diagnosing multiple organ-specific autoimmune diseases such as acute lung injury (Gao et al, 2007), pancreatic necrosis (Rahman et al, 2007) or gastric cancer of human (Xia et al, 2009). However, excess inflammatory response mediated by MIF will induce tissue injury or organ dysfunctions and even cause systemic inflammatory response syndrome (SIRS) (Gando et al, 2007).…”