Serum Magnesium and Cognitive Function Among Qatari Adults

Al-Ghazali, Kateba; Eltayeb, Sana; Musleh, Ayesha; Al-Abdi, Tamara; Ganji, Vijay; Shi, Zumin

doi:10.3389/fnagi.2020.00101

Cited by 16 publications

(22 citation statements)

References 41 publications

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Section: Discussionsupporting

confidence: 93%

“…The findings of our study were consistent with the results of most of the previous studies in both humans and animals [7][8][9][10][11][12][13][14][15][16][23][24][25][26]. A cross-sectional study conducted in Spain on 447 participants found that increased intake of Mediterranean-diet components including walnuts is linked to better cognitive function and increased working memory in elderly at high cardiovascular risk [27].…”

Section: Discussionsupporting

confidence: 92%

“…As proposed by previous studies, several mechanisms may explain the association between nuts consumption and cognitive function [8,10,16]. First, sufficient nuts consumption is beneficial for the prevention and management of chronic conditions including diabetes and hypertension, which are both considered risk factors of cognitive decline [29,30].…”

Section: Potential Physiological Mechanismsmentioning

confidence: 90%

“…Findings from animal studies suggest a beneficial effect of magnesium on cognitive function [13][14][15]. In human studies, serum magnesium and magnesium intake have been shown to be positively related to cognitive function [16]. It is unknown whether serum magnesium mediates the association between nuts consumption and cognitive function.…”

Section: Introductionmentioning

confidence: 99%

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Higher Habitual Nuts Consumption Is Associated with Better Cognitive Function among Qatari Adults

et al. 2021

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The association between nuts intake and cognitive function is inconclusive. We aimed to investigate the association between habitual nuts consumption and cognition among Qatari adults. Data from 1000 participants aged >20 years who attended Qatar Biobank (QBB) were used. Nuts consumption was assessed by a food frequency questionnaire (FFQ). Blood samples were measured for magnesium, lipids and glucose. Mean reaction time (MRT) was used as an indicator of cognitive function. Linear regression was used to assess the association. A total of 21.1% of the participants reported consuming nuts ≥4–6 times/week (high consumption) while 40.2% reported consuming ≤1 time/month (low consumption). The mean MRT was 715.6 milliseconds (SD 204.1). An inverse association was found between nuts consumption and MRT. Compared to those with a low consumption, high consumption of nuts had a regression coefficient of −36.9 (95% CI −68.1 to −5.8) after adjusting for sociodemographic and lifestyle factors. The inverse association between nuts and MRT was mainly seen among those >50 years. There was an interaction between nuts consumption and hypertension. The association between nuts consumption and MRT was not mediated by hypertension, diabetes, or serum magnesium. Habitual higher consumption of nuts is positively associated with cognitive function, especially among old adults.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Potential Physiological Mechanismsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Higher Habitual Nuts Consumption Is Associated with Better Cognitive Function among Qatari Adults

et al. 2021

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“…Concurrently, hypokalemic metabolic alkalosis, hypocalciuria, hypomagnesemia and activated RAAS with secondary hyperaldosteronism do not have strong neurological effects in these patients. However, magnesium deficiency might have cognitive effects [ 25 ]. It is worth noting that GS patients are often polysymptomatic (e.g.…”

Section: Introductionmentioning

confidence: 99%

Brain dysfunction in tubular and tubulointerstitial kidney diseases

Viggiano

Bruchfeld

Carriazo

et al. 2021

Nephrology Dialysis Transplantation

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Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria, predominant tubular injury, with or without tubulointerstitial disease, is typically non-proteinuric. CKD has been linked with cognitive impairment, but it is unclear how much this depends on a reduced GFR, altered tubular function or the presence of proteinuria. Since CKD is often accompanied by tubular and interstitial dysfunction, we explore here for the first time the potential role of the tubular and tubulointerstitial compartments in cognitive dysfunction. To help address this issue, we have selected a group of primary tubular diseases with preserved GFR, in which to review the evidence for any association with brain dysfunction. Cognition, mood, neurosensory, and motor disturbances are not well characterized in tubular diseases, possibly because they are subclinical and less prominent than other clinical manifestations. The available literature suggests that brain dysfunction in tubular and tubulointerstitial diseases is usually mild and is more often seen in disorders of water handling. Brain dysfunction may occur when severe electrolyte and water disorders in young children persist over a long period of time before the diagnosis is made. We have chosen as examples to highlight this topic, Bartter and Gitelman syndromes and nephrogenic diabetes insipidus. We discuss current published findings, some unanswered questions, and propose topics for future research.

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Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences

2023

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Purpose To examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age. Methods Participants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class analysis and hierarchical linear regression models were performed to investigate the association between baseline dietary Mg, Mg trajectories, and brain volumes and WMLs. Associations between baseline Mg, and baseline blood pressure (BP) measures, and baseline Mg, Mg trajectories and BP changes (between baseline and wave 2) were also investigated to assess whether BP mediates the link between Mg intake and brain health. All analyses controlled for health and socio-demographic covariates. Possible interactions between menopausal status and Mg trajectories in predicting brain volumes and WMLs were also investigated. Results On average, higher baseline dietary Mg intake was associated with larger brain volumes (gray matter [GM]: 0.001% [SE = 0.0003]; left hippocampus [LHC]: 0.0013% [SE = 0.0006]; and right hippocampus [RHC]: 0.0023% [SE = 0.0006]) in both men and women. Latent class analysis of Mg intake revealed three classes: “high-decreasing” (men = 3.2%, women = 1.9%), “low-increasing” (men = 1.09%, women = 1.62%), and “stable normal” (men = 95.71%, women = 96.51%). In women, only the “high-decreasing” trajectory was significantly associated with larger brain volumes (GM: 1.17%, [SE = 0.58]; and RHC: 2.79% [SE = 1.11]) compared to the “normal-stable”, the “low-increasing” trajectory was associated with smaller brain volumes (GM: − 1.67%, [SE = 0.30]; white matter [WM]: − 0.85% [SE = 0.42]; LHC: − 2.43% [SE = 0.59]; and RHC: − 1.50% [SE = 0.57]) and larger WMLs (1.6% [SE = 0.53]). Associations between Mg and BP measures were mostly non-significant. Furthermore, the observed neuroprotective effect of higher dietary Mg intake in the “high-decreasing” trajectory appears to be greater in post-menopausal than pre-menopausal women. Conclusions Higher dietary Mg intake is related to better brain health in the general population, and particularly in women.

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Serum Magnesium and Cognitive Function Among Qatari Adults

Cited by 16 publications

References 41 publications

Higher Habitual Nuts Consumption Is Associated with Better Cognitive Function among Qatari Adults

Higher Habitual Nuts Consumption Is Associated with Better Cognitive Function among Qatari Adults

Brain dysfunction in tubular and tubulointerstitial kidney diseases

Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences

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