Serum magnesium and stable asthma: Is there a link?

Das, Suman; Ak, Haldar; Ghosh, Indranath; Saha, Shyama Prasad; Das, Anirban; Biswas, Saurabh

doi:10.4103/0970-2113.71944

Cited by 20 publications

(19 citation statements)

References 15 publications

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“…This was in agreement with Das et al [17], who reported that there is statistically significant relationship of hypomagnesemia with the use of LABA, (p value = 0.003) and with the use of P3 medications, (p value = 0.007). In the same study Das et al [17], showed a statistically significant relationship of hypomagnesemia with use of ICS, (p value = 0.021) and explained this by increased urinary loss of magnesium as a side-effect of therapy with corticosteroid [9].…”

Section: Discussionsupporting

confidence: 94%

“…This result was in agreement with Alamoudi [13] who reported that the number of hospitalizations in chronic asthmatics with low Mg (40%) was significantly higher than that found in chronic asthmatics with normal Mg (11.8%), (p value = 0.04) and Das et al [17], who reported that there is statistically significant relation between serum Mg levels (normo or hypo) and previous and future exacerbations, (p value = 0.019). This can be explained that low serum Mg may increase airway hyper-reactivity, and hyper-responsiveness which renders chronic asthmatics with low Mg more prone to develop bronchoconstriction and acute exacerbations of asthma.…”

Section: Discussionsupporting

confidence: 91%

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Assessment of serum magnesium level in patients with bronchial asthma

Ali

Bakr

Yousif

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: Asthma is one of the most common chronic diseases worldwide and has been increasing in prevalence over the last few decades. Magnesium ion has an inhibitory action on smooth muscle contraction, histamine release from mast cells and acetylcholine release from cholinergic nerve terminals. Magnesium has been shown to relax bronchial smooth muscles and influence the function of respiratory muscles. Hypomagnesemia have been associated with diminished respiratory muscle power.Aim: To assess the serum Mg levels in bronchial asthma patients during stable and exacerbating clinical conditions. Subjects and methods: 60 Subjects were enrolled, 40 patients diagnosed as bronchial asthma and 20 healthy individuals as a control group. The asthmatic patients were divided into group (I) chronic stable bronchial asthma and group (II) acute exacerbation of bronchial asthma.Results: Serum Mg levels were significantly lower in asthmatic patients compared with healthy controls and significantly lower in asthmatic patients during exacerbation compared with stable asthmatics. There was a positive correlation between serum Mg levels and each of FEV1/FVC ratio and FEV1.Conclusion: Hypomagnesemia was found in patients with chronic stable asthma and also in those with acute asthma exacerbation compared to control. Serum mg levels were significantly lower in asthmatic patients during exacerbations compared with stable asthmatics.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

Assessment of serum magnesium level in patients with bronchial asthma

Ali

Bakr

Yousif

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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“…Low serum Mg levels in adult asthmatic patients have been described many years ago (9,29). Contrarily, some studies reported no difference between asthmatic patients and normal individuals, in terms of serum magnesium levels (10,11).…”

Section: Eurasianmentioning

confidence: 98%

“…As intracellular electrolyte measurement tests are expensive, they are not easily available and difficult for clinical application (29). Therefore, generally serum Mg levels are used for the monitoring of changes in body Mg concentration during acute attack and stable phases of asthma.…”

Section: Eurasianmentioning

confidence: 99%

Serum Magnesium Concentration in Children with Asthma

Hatipoğlu¹,

Hatipoğlu²,

Türel³

et al. 2014

Eurasian J Pulmonol

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Objective: Asthma is the most common chronic disease of childhood, and magnesium is one of the most frequently found minerals in human body and it is used in the treatment of asthma. Although there are studies on magnesium levels in adult patients with asthma, there is yet no data on the levels of magnesium in children. The present study compared the levels of serum magnesium between the children with asthma and healthy children. Methods:Children aged between 5 and 17 years with mild-moderate persistent asthma, who were admitted to our hospital between January 2009 and August 2010, were included in the study. Serum magnesium levels were measured in 50 patients with acute asthma attack, in 50 patients receiving treatment for stable asthma, and in 50 children admitted to the hospital for any reason and matched with asthma patients except for the diagnosis of asthma. The test was performed by photometric method using Roche-Hitachi Modular P biochemistry analyzer. The normal range of serum Mg was considered to be 1.59-to-2.10 mg/dL and p<0.05 was considered statistically significant. Results:All three groups were similar in terms of mean age and gender distribution. Although mean serum magnesium levels were within the normal range in healthy children and in children treated for stable asthma (1.89±0.32 and 1.93±0.34 mg/dL respectively), it was 1.62±0.26 mg/dL in children having an asthma attack, which was within the normal range but close to the lower limit (p<0.001). Conclusion:Although its efficacy has not been definitely proven, magnesium is used either via intravenous route or as inhaler in acute asthma attack. Knowledge about the changes in body magnesium levels of asthma patients would be a guide for revealing the role of magnesium in the treatment of asthma. As was shown in the present study, magnesium levels tend to decrease in the body during acute attack.

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“…This is the first study to assess the effects of hypomagnesemia on PFT of asthmatic patients. Mg 2+ replacement treatment was not effective in chronic asthmatic patients in previous studies [1,19]. In an epidemiological study, reduced intake of Mg 2+ was associated with hyperreactivity of the airways to methacholine.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma

et al. 2018

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Objective: To investigate the relationship between serum values of magnesium and the parameters of the pulmonary function tests (PFT) in patients with chronic asthma. Subjects and Methods: This study recruited 50 patients with chronic stable asthma and 40 healthy individuals as a control group. Data on age, sex, severity of asthma, PFT, and details of drug therapy were obtained from each group. Serum magnesium, potassium, phosphorus, calcium, and sodium levels were also measured. To evaluate differences between groups, the Student t test or Mann-Whitney U test was performed for continuous variables, and the χ² test for categorical variables. Results: In the asthma group, 10% (n = 9) of the patients had hypomagnesemia and 5.5% (n = 5) had hypophosphatemia. Patients with asthma were divided into two groups: the hypomagnesemic group (n = 9) and the normomagnesemic group (n = 41). Forced expiratory volume in 1 s (FEV₁), FEV₁%, peak expiratory flow (PEF), and PEF% were lower in the hypomagnesemic group than in the normomagnesemic group (p = 0.02). Multiple logistic regression analysis revealed a statistically significant association between hypomagnesemia and PFT in the hypomagnesemic asthmatic group. The correlations of age with FEV₁, FEV₁%, PEF, and PEF% were as follows: p = 0.00, r = 0.29; p = 0.00, r = 0.43; p = 0.03, r = 0.22; p = 0.00, r = 0.38; and p = 0.03, r = 0.22, respectively. The correlation of serum magnesium levels with PFT (FEV₁, FEV₁%, PEF, PEF%) were as follows: p = 0.001, r = 0.29; p = 0.001, r = 0.43; p = 0.03, r = 0.22; and p = 0.001, r = 0.38, respectively. The other electrolytes were within the normal range in both groups. Conclusion: In this study, hypomagnesemia and hypophosphatemia were found to be the most common electrolyte abnormalities in patients with chronic stable asthma. FEV₁, FEV₁%, PEF, and PEF% were significantly lower in asthmatic patients with hypomagnesemia compared to asthmatic patients with normomagnesemia.

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Serum magnesium and stable asthma: Is there a link?

Cited by 20 publications

References 15 publications

Assessment of serum magnesium level in patients with bronchial asthma

Assessment of serum magnesium level in patients with bronchial asthma

Serum Magnesium Concentration in Children with Asthma

The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma

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