Serum Magnesium as a prognostic marker in acute coronary syndromes and its correlation with coronary prognostic index

Abstract

Aim: The aim is to evaluate Serum Magnesium as a prognostic marker in Acute Coronary Syndromes (ACS) and to compare with Coronary Prognostic Index (CPI). Methods: This case control study conducted in the intensive care unit (ICU) of AVBRH, Sawangi, Wardha taking 150 cases of ACS and 150 healthy age and sex matched controls. CPI was calculated in the cases of ACS and Serum Magnesium was calculated on admission for cases and controls and was compared between them. P value of <0.05 was taken as significant.Results: 6% of the cases gave history of myocardial infarction and 22% gave history of Angina and 34.6% gave history of smoking. Mean levels of serum Magnesium on admission (mg/dL) in cases was 1.82 ± 0.29 and among controls was 1.86 ± 0.23 with no significant difference between them. The prevalence of Hypomagnesemia was seen in 30% of cases and 19.33% of controls. Significant negative correlation was seen between serum Magnesium levels on admission with CPI with correlation coefficient of (r=-0.293, p<0.01).Mean ± SD of CPI in patients with hypomagnesemia was 10.42 ± 5.36 which was significantly higher as compared to patients without hypomagnesemia (7.3± 3.34). Conclusion: This study concluded that MI was more prevalent among the male population than the female population. Hypertension, smoking, alcohol and diabetes are the common independent risk factors for ACS. Serum Magnesium levels can be predictive of severity of outcome in cases of ACS and is correlated negatively with CPI.

Prevalence of Hypomagnesaemia among Patients with Acute Myocardial Infarction and its Correlation to Intra-hospital Complications

“…Serum magnesium was found to be a signi cant predictor for major adverse cardiac events of acute myocardial infarction [11], especially low serum magnesium, which negatively correlates with the coronary prognostic index and severity of outcomes [12,13].Magnesium has been known to have an in uence on acute myocardial infarction sequels like arrhythmias, and it plays a major role in the pathogenesis of other cardiovascular diseases as well. Serum magnesium level, though important, is not a routine investigation done in all patients with acute myocardial infarction in our practice, so this study was designed to highlight the importance of magnesium in the etiology, prognosis, and all-case morbidity and mortality of AMI and even to prompt the role of early recognition and management of hypomagnesemia in decreasing intra-hospital and overall cardiac deaths secondary to IHD, HF, and arrhythmias.…”