Serum Magnesium Levels in Women with Breast Cancer in Benin City, Nigeria

Atoe, Kenneth

doi:10.9734/ijtdh/2014/5041

Cited by 6 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, magnesium was deficient in 42% of the patients with breast cancer and in 5% of the control group. Magnesium levels were significantly lower in the breast cancer group (p<0.001), which is in agreement with Sartori et al [23] and Atoe et al [22], which suggests that serum Mg was significantly lower in the patients with breast cancer compared to the control group and contradictory to the findings by Arinola et al [28] who reported slight hypomagnesaemia in patients with breast cancer. Abdelgawad et al [29] found no significant difference when comparing Mg levels between the breast cancer and the control group.…”

Section: Discussionsupporting

confidence: 85%

“…In the present study, ALP and calcium showed a non-significant rise in non-metastatic cases and registered a significant rise (p<0.001) in metastatic patients, respectively, which is consistent with the findings of Uemura et al [20] and Mulholland et al [21] which indicate no significant difference in ALP levels in non-metastatic breast cancer. Atoe et al [22] revealed a significant rise in ALP and calcium in metastasis and no change in non-metastatic groups, which suggested the involvement of bone in cancer metastasis.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Serum bone profile and cathepsin K expression as a prognostic factor in patients with and without breast cancer metastasis

Samuel¹

2020

Int J Med Biochem

View full text Add to dashboard Cite

Serum bone profile and cathepsin K expression as a prognostic factor in patients with and without breast cancer metastasis B reast cancer is the most common malignancy among women and the leading cause of death. The majority of the cases are diagnosed at an advanced stage with a higher incidence of skeletal metastases [1][2][3]. Metastatic disease to the bone has been a crippling devastating complication of breast cancer, leaving patients bedridden or wheelchair-bound and victims of suffering from intolerable pain. The biological mechanisms leading to bone metastasis have been referred to as "vicious cycle" a complex network between cancer cells and the bone microenvironment [4]. Besides clinical and imaging techniques, biochemical tests play a vital role in the assessment and differential diagnosis of bone metabolic disorder in breast cancer [5]. These biochemical indices are non-invasive, comparatively low-cost and when applied and interpreted correctly, it is a great tool among the diagnostic and therapeutic assessment of metabolic bone Objectives: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide. Breast cancer bone metastasis is associated with skeletal events, including acute fractures, compression of the spinal cord, surgery and radiotherapy to the spine, as well as bone pain and hypercalcemia, resulting in decreased mobility and diminished quality of life. Greater understanding of the bone metastasis pathophysiology will highly likely to lead to the discovery of an effective treatment option. This study aims to test whether the serum bone profile and expression level of cathepsin K (CTSK) in breast carcinoma is associated with metastasis. Methods: In this study, 116 participants, 58 patients who had been diagnosed with breast cancer (n=22 without metastasis and n=36 with metastasis) and 58 healthy controls were included. Serum biochemical profile and immunostaining of CTSK in the breast carcinoma were investigated.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 98%

Serum bone profile and cathepsin K expression as a prognostic factor in patients with and without breast cancer metastasis

Samuel¹

2020

Int J Med Biochem

View full text Add to dashboard Cite

show abstract

“…Serum Mg levels in this study were statistically not different in the control and CIN groups evaluated. This observation is different from the report from a study to compare serum Mg levels in women with breast cancer in Benin City, Nigeria (Atoe et al, 2014). In the just mentioned study, results showed a significant reduction in serum Mg levels of patients with breast cancer compared with those without the disease.…”

Section: Atoe K; Peter Oocontrasting

confidence: 89%

Serum antioxidant status and some selected trace metal levels in patients with cervical intraepithelial neoplasm in Benin City, Nigeria

Atoe¹,

Peter²

2019

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

Antioxidants are important in the detoxification of free radicals, which are the hazardous derivatives of metabolic processes in the body. However, the mop up of free radicals in the prevention and management of cervical intraepithelial neoplasm is not clear. This study presented an assessment of the status of catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), total antioxidant capacity (TAC) and some trace metals (Ca, Mg, Cu and Zn) in women diagnosed with Cervical Intraepithelial Neoplasm (CIN) lesions. The study was carried out at the Iyamho, Edo state Nigeria. Study participants were grouped into two; those with CIN lesions (n = 144) and the control (n = 53). Venous blood was obtained from participants and serum antioxidant levels were determined using standardized laboratory methods. Results showed that CAT levels increased significantly from 23.88 u/µl/min in the control group to 31.79 u/µl/min in CIN. The incidence of cervical intraepithelial neoplasm lesions did not significantly affect total antioxidant capacity (TAC) of the study population (2.43 -2.70 mM, P>0.05). There were minimal increases in antioxidant status between the control and CIN groups respectively (P> 0.05). Cu was implicated as the only trace metal within the CIN group without significant correlation to the antioxidants investigated.

show abstract

“…Results similar to our study were observed in study conducted by researchers Atoe et al, in 2014 in Nigeria. They demonstrated that serum Mg levels were lower in Breast Cancer patients as compared to healthy controls [17].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Magnesium (Mg) and Zinc (Zn) in Carcinoma Breast Patients

SONGARA¹,

BHARGAVA²,

CHAUDHARY³

et al. 2022

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: The objectives of the study were to determine and compare serum magnesium (Mg) and zinc (Zn) concentrations between breast carcinoma patients and healthy controls. Methods: Determination and comparison of serum Mg and Zn was done between 50 breast carcinoma patients and 50 healthy controls. Determination and comparison of LFT in between 50 breast cancer patient during different course of chemotherapy. Trace element analysis was done using atomic absorption spectrophotometry. Statistical comparison was done, results were expressed as Mean±SD, p<0.05 was considered to be statistically significant. Results: All groups were statistically matched in age, sex, and p>0.05. Serum Mg concentrations in cases and controls (0.9920±0.38 mg/dL) and (1.49±0.58 mg/dL) respectively, p≤0.0001* serum Zn concentrations in cases and controls were (66.74±12.58 μg/dL) and (90.88±14.51 μg/dL), respectively, p≤0.0001*. Conclusion: Both serum (Zn) and (Mg) showed significant decreases in breast carcinoma patients as compare to healthy controls.

show abstract

Serum Magnesium Levels in Women with Breast Cancer in Benin City, Nigeria

Abstract: Aim:The aim of this study was to compare the serum magnesium levels of patients with breast cancer and apparently healthy people without the disease. Study Design: This is a cross-sectional prospective study.

Cited by 6 publications

References 11 publications

Serum bone profile and cathepsin K expression as a prognostic factor in patients with and without breast cancer metastasis

Serum bone profile and cathepsin K expression as a prognostic factor in patients with and without breast cancer metastasis

Serum antioxidant status and some selected trace metal levels in patients with cervical intraepithelial neoplasm in Benin City, Nigeria

Assessment of Magnesium (Mg) and Zinc (Zn) in Carcinoma Breast Patients

Contact Info

Product

Resources

About