Serum Markers Measured in FNA Fluids of Medullary Thyroid Carcinoma Occurring as a Cyst

Trimboli, Pierpaolo; Guidobaldi, Leo; Locuratolo, Nicola; Piro, F.; Giordano, Marco; Giovanella, Luca

doi:10.5301/jbm.5000205

Cited by 8 publications

(9 citation statements)

References 10 publications

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“…To date, only one paper has been published on the use of ProCT in the washout fluids from FNAC ( 21). In that case report, we showed that the determination of ProCT in FNAC from an MTC is technically feasible, even if this finding should be evaluated in larger series.…”

Section: Discussionmentioning

confidence: 85%

Procalcitonin as a postoperative marker in the follow-up of patients affected by medullary thyroid carcinoma

Trimboli

Lauretta²,

Barnabei³

et al. 2018

Int J Biol Markers

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Section: Discussionmentioning

confidence: 85%

Procalcitonin as a postoperative marker in the follow-up of patients affected by medullary thyroid carcinoma

Trimboli

Lauretta²,

Barnabei³

et al. 2018

Int J Biol Markers

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“…Nevertheless, the number of cases with negative serum CT is negligible, and most of these were undifferentiated tumors or microcarcinomas [6,90,91]. On the other side, this measurement seems reliable also in MTC with ultrasound presentation as pure cyst [92].…”

Section: Samplingmentioning

confidence: 92%

Measurement of thyroglobulin, calcitonin, and PTH in FNA washout fluids

Trimboli

D’Aurizio

Tozzoli

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Different imaging tools, circulating endocrine markers, and fine-needle aspiration (FNA) cytology are of great importance in the diagnosis and follow-up of different thyroid and parathyroid diseases. Sometimes, however, they are conflicting or inconclusive: interestingly, measuring endocrine markers (i.e. thyroglobulin, calcitonin, parathyroid hormone) in fluids from FNA proved to be a very useful complementary diagnostic tool in such cases. The determination of endocrine markers in fluids other than serum/ plasma has been developed in the last years. Although studies have reported overall satisfactory results, a good standardization of procedures has not yet been reached, and further efforts should be made in order to better define preanalytical, analytical, and post-analytical aspects. Here we reviewed critically the literature on the measurement of FNA endocrine markers, focusing on laboratory issues, such as preparation of the sample, choice of solution, and technical features of determination of these markers. Indeed, information for use of FNA-Tg, FNA-CT, and FNA-PTH in clinical practice was also provided.

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“…10 Cystic MTC is a rare clinical presentation with only a few cases reported. 11 FNA diagnosis of MTC can be difficult due to the variety of cytomorphological appearances, as it exhibits cellular pleomorphism, with small cells, elongated cells, and plasmacytoid cells with eccentric nuclei. The nuclei are small and round to elongated, sometimes binucleated, with finely granular chromatin patterns typical of neuroendocrine tumours.…”

Section: Ys Ti C Thyroid Le S I On Smentioning

confidence: 99%

Some uncommon cystic lesions in the anterior head and neck region: Pitfalls to be avoided on cytology

et al. 2023

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Cystic lesions of the anterior head and neck region are a challenging and frequent finding on cytological smears. The scant amount of cellular material in cystic slides poses the greatest difficulty to interpretation, so that frequently they are diagnosed as inadequate or with minimal cellular component. Despite the majority of cystic lesions being benign, a minor portion consist of malignant cystic entities. In these latter cases, the evidence of very scant malignant cells can be misdiagnosed and/or underestimated, leading to a false negative diagnosis. Many papers have already described and detailed the range of possible benign and malignant cystic lesions in head and neck. In the current review we have focused on the less common entities that often lead to serious misinterpretation.

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Serum Markers Measured in FNA Fluids of Medullary Thyroid Carcinoma Occurring as a Cyst

Abstract: In the presence of a cystic thyroid lesion the diagnosis of MTC should be taken into account, and measuring calcitonin in FNA fluid is relevant. The determination in FNA of other markers is technically feasible but its role should be evaluated in larger series.

Cited by 8 publications

References 10 publications

Procalcitonin as a postoperative marker in the follow-up of patients affected by medullary thyroid carcinoma

Procalcitonin as a postoperative marker in the follow-up of patients affected by medullary thyroid carcinoma

Measurement of thyroglobulin, calcitonin, and PTH in FNA washout fluids

Some uncommon cystic lesions in the anterior head and neck region: Pitfalls to be avoided on cytology

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