Serum metabolic profiles of septic shock patients based upon co-morbidities and other underlying conditions

Pandey, Swarnima; Siddiqui, Mohd Adnan; Azim, Afzal; Trigun, Surendra Kumar; Sinha, Neeraj

doi:10.1039/d0mo00177e

Cited by 7 publications

(4 citation statements)

References 70 publications

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“…Works by Pandey et al illustrated the metabolic alteration in patients with sepsis and septic shock due to the presence of comorbid conditions like diabetes and hypertension 98 , gender 99 , and alteration in metabolic profile during disease or progression of the disease 100 , 101 .…”

Section: Metabolomicsmentioning

confidence: 99%

Sepsis, Management & Advances in Metabolomics

Pandey

2024

Nanotheranostics

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Though there have been developments in clinical care and management, early and accurate diagnosis and risk stratification are still bottlenecks in septic shock patients. Since septic shock is multifactorial with patient-specific underlying co-morbid conditions, early assessment of sepsis becomes challenging due to variable symptoms and clinical manifestations. Moreover, the treatment strategies are traditionally based on their progression and corresponding clinical symptoms, not personalized. The complex pathophysiology assures that a single biomarker cannot identify, stratify, and describe patients affected by septic shock. Traditional biomarkers like CRP, PCT, and cytokines are not sensitive and specific enough to be used entirely for a patient's diagnosis and prognosis. Thus, the need of the hour is a sensitive and specific biomarker after comprehensive analysis that may facilitate an early diagnosis, prognosis, and drug development. Integration of clinical data with metabolomics would provide means to understand the patient's condition, stratify patients better, and predict the clinical outcome.

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Section: Metabolomicsmentioning

confidence: 99%

Sepsis, Management & Advances in Metabolomics

Pandey

2024

Nanotheranostics

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“…Metabolomics is a powerful phenotyping tool to measure all small molecules/metabolites present in a biological system and accessible to analysis. 12 Metabolomics reflects the phenotype of an individual in terms of the biochemical alteration that occurs in response to disease. It is one of the emerging technologies contributing significantly to providing prognosis biomarkers of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Gender-specific association of oxidative stress and immune response in septic shock mortality using NMR-based metabolomics

et al. 2022

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“…The study of metabolome (metabolomics) is gaining increasing attention and is believed to have the potential to alter clinical practice in sepsis 10 , 11 . In fact, it is believed that putting too much pressure on sepsis as an inflammatory condition and not addressing other contributing factors, including profound changes in metabolic homeostasis, might be the reason for the failure of many biomarkers and clinical trials 12 .…”

Section: Introductionmentioning

confidence: 99%

“…One such pathological condition for which the determination of amino acids may have potential value is sepsis. Recently, there has been an increase in the number of scientific papers which have studied the relevance of amino acid concentrations in sepsis or septic shock 7 , 11 , 20 .…”

Section: Introductionmentioning

confidence: 99%

An analysis of urine and serum amino acids in critically ill patients upon admission by means of targeted LC–MS/MS: a preliminary study

Mierzchała-Pasierb

Lipińska-Gediga

Fleszar

et al. 2021

Sci Rep

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Sepsis, defined as a dysregulated host response to infection, causes the interruption of homeostasis resulting in metabolic changes. An examination of patient metabolites, such as amino acids, during the early stage of sepsis may facilitate diagnosing and assessing the severity of the sepsis. The aim of this study was to compare patterns of urine and serum amino acids relative to sepsis, septic shock and survival. Urine and serum samples were obtained from healthy volunteers (n = 15) once or patients (n = 15) within 24 h of a diagnosis of sepsis or septic shock. Concentrations of 25 amino acids were measured in urine and serum samples with liquid chromatography-electrospray mass spectrometry. On admission in the whole cohort, AAA, ABA, mHis, APA, Gly-Pro and tPro concentrations were significantly lower in the serum than in the urine and Arg, Gly, His, hPro, Leu, Ile, Lys, Orn, Phe, Sarc, Thr, Tyr, Asn and Gln were significantly higher in the serum than in the urine. The urine Gly-Pro concentration was significantly higher in septic shock than in sepsis. The serum Cit concentration was significantly lower in septic shock than in sepsis. The urine ABA, mHis and Gly-Pro, and serum Arg, hPro and Orn concentrations were over two-fold higher in the septic group compared to the control group. Urine and serum amino acids measured in septic patients on admission to the ICU may shed light on a patient’s metabolic condition during sepsis or septic shock.

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Serum metabolic profiles of septic shock patients based upon co-morbidities and other underlying conditions

Abstract: Serum based identification of potential molecular biomarkers of septic shock using NMR spectroscopy.

Cited by 7 publications

References 70 publications

Sepsis, Management & Advances in Metabolomics

Sepsis, Management & Advances in Metabolomics

Gender-specific association of oxidative stress and immune response in septic shock mortality using NMR-based metabolomics

An analysis of urine and serum amino acids in critically ill patients upon admission by means of targeted LC–MS/MS: a preliminary study

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